Using individual level survival prediction to estimate years of life lost due to Covid-19 and their socio-economic distribution
excess mortatlity
Set of responses on the initial items in the Rotterdam Anesthesia Knowledge Questionnaire used to further develop and validate the questionnaire. Data was collected on 2 locations, indicated by the location variable. Responses are recoded into right (1)/wrong (0). There are restrictions on use by commercial parties, and on sharing openly based on (inter)national laws and regulations and written informed consent. Therefore these data (and additional clinical data) are only available upon signing a Data Transfer Agreement (see Terms of Access)
Rotterdam Anesthesia Knowledge Questionnaire
Surveys and Questionnaires
Anesthesia
a prospective cohort study of patients with neuroendocrine tumors, fecal samples
Role of the gut microbiome in neuroendocrine tumors
Mesh
microbiota
Neuroendocrine Tumors
Samenwerken tegen Corona met Intensive Care Data
national
human disease
intensive care
COVID-19 patient grouping
COVID-19
hospital care
COVID-19 phase
Supplementary table 1-3 for Chapter 6 - List of all differentially expressed genes (DEGs) per comparison. Each table shows the list of all DEGs for a given comparison, shown in separate tabs for up- or downregulated DEGs. Per DEG, the log2 Fold Change and adjusted p-value (padj) are shown. Data is shown for Ganetespib vs Control, 24h (table 1), PRRT + ganetespib vs PRRT, 24h (table 2) and PRRT + ganetespib vs PRRT, 72h (table 3). Data belongs to Chapter 6 "Targeting heat shock protein 90 to radiosensitize neuroendocrine tumor cells to PRRT: mechanisms outside DNA double-strand break repair" in PhD thesis ''Improving Peptide Receptor Radionuclide Outcomes - A Radiobiological Approach" by Thom Reuvers (2024).
Supplementary table 1-3 for Chapter 6 - List of all differentially expressed genes per comparison
Gene expression
Developing and testing of behavioral interventions to prevent COVID-19 infection and spreading
people s everyday lives
people by age
other
people by education
people by gender
surveillance phase
Data collected for the iGENE study, associating MRI with IDH mutation, 1p/19q codeletion and grade of adult-type diffuse glioma. For internal use only.
iGene
collection type: Disease specific,Sample collection | disease: Subarachnoid haemorrhage,Intracerebral haemorrhage,Cerebral infarction,Stroke, not specified as haemorrhage or infarction,Transient cerebral ischaemic attack, unspecified | data categories: Biological samples,Imaging data,Medical records,Physiological/Biochemical measurements | materials: Plasma | omics: Other | imaging: Y | sex: Female,Male
To develop a liquid biopsy biomarker that can differentiate between the cause of stroke (ischemic and hemorrhagic stroke) in the acute phase, new technology will be developed and nanoparticles (small RNAs and extracellular vesicles) will be measured in plasma samples from patients with a supsicion of stroke.
Circulating Nanotraces to Identify the Cause of Stroke
CINTICS
unspecified
Intracerebral haemorrhage
Sample collection
Biological samples
Transient cerebral ischaemic attack
Subarachnoid haemorrhage
Plasma
Imaging data
Physiological Biochemical measurements
Cerebral infarction
not specified as haemorrhage or infarction
Other
Female
Male
Disease specific
Medical records
Stroke
Hartwig Medical Foundation whole genome sequencing dataset. The Hartwig Medical Database is a continuously growing resource containing whole genome and whole transcriptome sequencing data. This is the largest database of metastatic tumor data obtained with WGS in the world. The uniqueness of the database consists of combining genetic data with treatment and treatment outcome data. The incidence of solid tumors in the Netherlands is reflected in the quantity and frequency of the tumor types in the database. In addition to molecular data, the database also contains an ever-growing list of tumor clinical characteristics. Our processes are standardized from sample preparation to patient reporting assuring a highly consistent dataset.
Cancer Whole Genome Sequencing
Whole genome sequencing
Metastasis
Response
Cancer or benign tumor
Treatment
Primary
Follow-up
Diagnosis
Tumor normal matched pair
Clinical data
Data Access Committee of the Hartwig Medical Foundation
Covid-19 lockdown and its impact on mortality rate in Alzheimer's - the CORAL project
Alzheimer s disease
The dataset contains all the raw data (RT-PCR, enzyme activity measurement, immunohistochemical staining quantification, Western blots) of the data presented in the manuscript 'EPO-overexpressing kidney organoids engineered using an episomal DNA vector exhibit physiological effects after subcutaneous implantation'
EPO-overexpressing kidney organoids engineered using an episomal DNA vector exhibit physiological effects after subcutaneous implantation
Erythropoietin
Regenerative medicine
Kidney organoid
DNA vector
The dataset provides the data collected in the eCRF during the conduct of the clinical trial. It contains, the baseline characteristics of the patients, the diagnostic tests that were performed to confirm the diagnosis of an invasive aspergillus infection and their results, the antifungal therapy the patient received and data regarding mortality up to week 24.
Azole-echinocandin combination therapy for invasive aspergillosis. A multicenter pragmatic randomized superiority trial
aspergillosis invasive pulmonary
mesh
Dit project draait om geautomatiseerde analyse van CT-schedel en MRI-hersenen bij patienten met craniosynostose, welke gerelateerd worden aan klinsiche uitkomstmaten. Gaillard L, Tjaberinga M, Dremmen MHG, Mathijssen IMJ, Vrooman H. Brain volume in infants with metopic synostosis: less white matter volume with an accelerated growth pattern in early life. J Anat. Accepted. De Planque CA, Gaillard L, Vrooman HA, Li B, Bron EE, Van Veelen MLC, Mathijssen IMJ, Dremmen MHG. A diffusion tensor imaging analysis of frontal lobe white matter microstructure in trigonocephaly patients. Ped Neurol. 2022 131:42-48 Wilson AT, den Ottelander BK, de Goederen R, van Veelen MLC, Dremmen MHG, Persing JA, Vrooman HA, Mathijssen IMJ. Intracranial hypertension and cortical thickness in syndromic craniosynostosis. Dev Med Child Neurol 2020;62:799-805
Craniosynostose
Data for Nivel Primary Care General Practices 2014
collection type: Disease specific,Hospital,Image collection,Longitudinal,Sample collection | disease: HFpEF | data categories: Biological samples,Imaging data,Medical records | materials: Plasma,Serum,Urine | imaging: Y | sex: Female,Male
In this phase 2 trial, we expect to obtain proof of concept for a beneficial effect of GGA on HFpEF. In HFpEF patients we will evaluate effects of GGA on signs and symptoms of HFpEF including echographic parameters of diastolic function, exercise tolerance, microvascular endothelial function and kidney function.
GeranylGeranylAcetone in Heart failure with preserved ejection fraction
Longitudinal
Serum
HFpEF
Urine
Hospital
GLADIATOR-HFpEF part of RECONNEXT
Image collection
Kritische materialen in een crisis; Material Supply Strategies in a Crisis
Material Supply Strategies in a Crisis
People with procurement expertise involved in buying medical equipments during Covid-19
international
home care
nursing home care
health care phase
Mentally disabled care
collection type: Cohort,Longitudinal | disease: Atherosclerotic heart disease,Heart failure,Atrial fibrillation and flutter | data categories: Biological samples,Physiological/Biochemical measurements,Survey data | materials: Serum | omics: Not available | imaging: N | sex: Female,Male
A diagnostic cluster randomized trial in patients participating in primary care disease management programs for COPD or type 2 diabetes. An early diagnosis strategy will be compared with usual care (650 vs. 650 participants). primary end point: difference in number of newly diagnosed cases of heart failure, atrial fibrillation or coronary artery disease between the two arms.
REVIVING EARLY DIAGNOSIS OF CARDIOVASCULAR DISEASE
Atrial fibrillation and flutter
RED-CVD
Not available
Atherosclerotic heart disease
Cohort
Survey data
Heart failure
This dataverse contains supportive proteomics, transcriptomics, histochemical, flow cytometric and clinical data for the research article: Maud Heredia, et al., Combined plasma protein and memory T cell profiling discern IBD-patient-immunotypes related to intestinal disease and treatment outcomes. Mucosal Immunol. 2024 Sep 26:S1933-0219(24)00097-7. doi: 10.1016/j.mucimm.2024.09.004.
Data for "Combined plasma protein and memory T cell profiling discern IBD-patient-immunotypes related to intestinal disease and treatment outcomes"
Neutrophils
Pediatric
Crohn s disease
Memory CD4 T cells
Inflammatory Bowel Disease
Ulcerative colitis
Immunology
Proteomics
ex-Th17
Conditions for technological solutions in a COVID-19 exit strategy, with particular focus on the legal and societal conditions
General population adult population of The Netherlands
10430012010002: Integrative analysis of multi-omics longitudinal data to identify effective strategies for the prediction and treatment of COVID-19
Integrative analysis of multi-omics longitudinal data to identify effective strategies for the prediction and treatment of COVID-19
people by COVID-19 risk factors
Acute and chronic respiratory failure
viral disease
people by sex
collection type: Non-Human
DCVA sample collection Renal connection to microvascular disease and heart failure with preserved ejection fraction: the next phase
Renal connection to microvascular disease and heart failure with preserved ejection fraction: the next phase
Non-Human
RECONNEXT non-clinical part
Metadata on Pseudomonas aeruginosa carriage and associated risk factors among healthy individuals and newly admitted patients from Rotterdam, Rome, and Jakarta. Data extracted from the eCRF can be made available by the authors for reuse upon request through point of contact mentioned above.
Pseudomonas aeruginosa carriage in healthy individuals and patients from Rotterdam, Rome, and Jakarta: a cross-sectional study and risk factor analysis
Risk factors
Pseudomonas aeruginosa
Carrier State
Humans
Prevalence
This dataset includes patient and clinical characteristics, and questionnaire responses of n=107 patients whom participated in the study: "A head-to-head comparison of the adult EQ-5D-5L and youth EQ-5D-Y-5L in adolescents with idiopathic scoliosis". Patients were treated with a brace for their scoliosis during this study. Patient characteristics include self-reported characteristics including age, sex, education, BMI. Clinical characteristics include cobb angle at diagnosis, at initiation of bracing, at inclusion in this study, and Lenke classification. Questionnaires include a first measurement of the EQ-5D-5L, EQ-5D-Y-5L, the corresponding Visual Analogue Scales, the SRS-22r (scoliosis-specific questionnaire). A second measurement of these questionnaires was obtained at least 7-14 days after completions of the first; approximately 75% of patients responded to the second measurement.
A head-to-head comparison of the adult EQ-5D-5L and youth EQ-5D-Y-5L in adolescents with idiopathic scoliosis
EQ-5D
Adolescents
Patient-reported Outcome Measure
Orthopedic Surgery
Scoliosis
Monitoring the evolution spread and transmission of SARS-CoV-2 through whole genome sequencing to enable fast genotype to phenotype prediction
alle verzekerden die vallen onder de Zorgverzekeringswet (Zvw)
De kostengegevens in de Vektis open databestanden zijn onderverdeeld naar verschillende kostensoorten binnen de zorgverzekeringswet; zoals medisch-specialistische zorg, farmacie, geestelijke gezondheidszorg, huisartsenzorg, hulpmiddelen, mondzorg, paramedische zorg en kraamzorg. Deze zorgkosten zijn uitgesplitst naar geslacht en leeftijdsklasse. De informatie is beschikbaar op postcode3-niveau (de eerste 3 cijfers van de postcode) en op gemeenteniveau (gemeentelijke indeling 2025 bij bestand 2023, gemeentelijke indeling 2024 bij bestand 2022, gemeentelijke indeling 2023 bij bestand 2021, gemeentelijke indeling 2022 bij bestand 2020, gemeentelijke indeling 2021 bij bestand 2019, gemeentelijke indeling 2020 voor de andere jaren). Deze metadata gaat over het opendatabestand op gemeenteniveau. De bestanden zijn bovendien op geaggregeerd niveau, zodat privacy gewaarborgd is en data nooit herleidbaar zijn naar individuele personen en zorgverzekeraars. De bestanden bevatten geaggregeerde data van alle verzekerden binnen de Zorgverzekeringswet. 2023 is op dit moment de versie met de meest recent beschikbare gegevens. Medio 2026 voegen we weer nieuwe bestanden toe.
Vektis open databestand op gemeenteniveau
geaggreerde data
geslacht
zorgverzekeringswet
leeftijd
declaratiegegevens zorgverzekeraars
gemeente niveau
Zorgkosten
These files consist of data and Matlab code needed to reproduce the main figures from Experiments 1, 2, and 3 of âLearning to stand with sensorimotor delays generalizes across directions and from hand to leg effectorsâ. Data and results include standing balance behavior quantified with different metrics (angular velocity variance, percent time within balancing limits, ankle torque standard deviation) when standing in baseline conditions or with imposed delays. Data are provided in .mat matlab files (to run with source code).
Data and code for "Learning to stand with sensorimotor delays generalizes across directions and from hand to leg effectors"
motor learning
adaptation
generalization
sensorimotor delay
standing balance
Establishment and duration of protective immunity against SARS-CoV-2 in relation to severity of SARS-CoV-2 infection.; Establishment and duration of protective immunity against SARS-CoV-2 in relation to severity of SARS-CoV-2 infection.
Establishment and duration of protective immunity against SARS-CoV-2 in relation to severity of SARS-CoV-2 infection.
health care employees
residential care
blood bank employees
antibody responses and inflammatory diseases
Primary care Research on Outcomes of COVID-19 (PROCOVID-19)
Long COVID
COVID-19 suspected patients
GP care
Kids and SARS-CoV-2 transmission and disease (CoKids study)
People by household
Coronavirus infection unspecified
Acute upper respiratory infection unspecified
Leren dansen. Sturing van zorg in tijden van een pandemie
The project focused on decision-making at the regional level across all care settings
regional
We followed decision-making during all phases
We followed decision-makers regulators managers professionals and patient representatives.
we didn t follow a disease
Psychosocial effects of Corona in Alzheimer's disease
COVID-19 Follow-up care paths and Long-term Outcomes Within the Dutch health care system: a combined rehabilitation, pulmonary, and intensive care perspective
rehabilitation
transmural
Design: The CAST is a pragmatic, open-label, multicenter, two-period cluster-randomized superiority trial. Enrollment took place from 30 May 2020 until 11 November 2021, and patients were followed for one year. Setting: Inclusion took place at the emergency department in ten hospitals located in the Netherlands. Participants: Eligible participants had a displaced DRF that was acceptably aligned after closed reduction. Interventions: A below-elbow complete circumferential cast (CC) or a below-elbow plaster of Paris volar-dorsal splint (PS).
How should we treat a patient with a distal radius fracture after closed reduction? A cluster RCT
LCSH
cast
distal radius fracture
re-dislocation
MesH
Zorgen en zwaaien
regulation phase
people with mental disabilities
next of kin of people with mental disabilities
collection type: Other | disease: Obesity | data categories: Medical records,Survey data | materials: Not available | omics: Not available | imaging: N | sex: Female,Male
In the five year LIKE programme (2017-2022), we develop, implement and evaluate an integrated action programme at the level of family, school, neighbourhood, health care and city, based upon a detailed insight into the characteristics of the population at stake. The aim is to tackle the wicked problem of childhood overweight and obesity in 10-14 year old adolescents in Amsterdam, using a systems dynamics and participatory approach. Following the principles of Participatory Action Research (PAR), we work with our population (adolescents and their families) and societal stakeholders as co-creators and co-investigators.
Lifestyle Innovations Based on youth's Knowledge and Experience
LIKE
Obesity
collection type: Longitudinal | disease: Obesity,Primary pulmonary hypertension,Disorders of lipoprotein metabolism and other lipidaemias - Pure hypercholesterolaemia,Mood [affective] disorders | data categories: Biological samples,Imaging data,Physiological/Biochemical measurements,Survey data | materials: Buccal Swab,Feaces,Peripheral blood cells,Plasma | omics: Metabolomics | imaging: Y | sex: Female,Male
Follow up of women (with obesity and unfulfilled wish for a child) and their children who participated in a preconception lifestyle intervention with focus on women's lifestyle, health and wellbeing and child growth, development, behavior and health (including cardiac ultrasound and MRI in children)
WOMB project: Women Offspring and iMproving lifestyle for Better cardiovascular health of Both
Mood affective disorders
WOMB
Peripheral blood cells
Primary pulmonary hypertension
Buccal Swab
Disorders of lipoprotein metabolism and other lipidaemias - Pure hypercholesterolaemia
Metabolomics
Feaces
Contains raw EMT measurement data used and described in "Afterloader integrated EMT enables improved dwell position model definition and quality assurance in Venezia gynaecological brachytherapy applicators ".
Replication Data for: "Afterloader integrated EMT enables improved dwell position model definition and quality assurance in Venezia gynaecological brachytherapy applicators "
Electromagnetic Tracking
Brachytherapy applicators
The aim of the CO-FLOW study is to follow the health care paths of all COVID-19 patients who survived hospitalization in the Rotterdam-Rijnmond region over a 2 years-period and to systematically study physical, cognitive and psychological health outcomes over time.
COVID-19 Follow-up care paths and Long-term Outcomes Within the Dutch health care system
Aftercare
Treatment Outcome
MeSH
Prospective Studies
Determinants of excess mortality rates in nursing homes
Nursing home residents
collection type: Cohort,Disease specific,Image collection | data categories: Imaging data,Medical records | materials: Not available | omics: Not available | imaging: Y | sex: Female,Male,Undifferentiated
The CAS study is a clinical observational study investigating the effects of ConAoS on the left ventricular function and the prevalence, pattern and expanse of LVH, myocardial stiffness and myocardial fibrosis. Moreover, we will assess the prognostic capacity of the presence of these pathological processes, correlating our findings at baseline to clinical outcome by assessing the occurrence of cardiovascular events and all-cause mortality during 3-year clinical follow-up. We will unravel biomarker and imaging predictors for myocardial dysfunction (systolic and diastolic) with specific attention for male-female differences
Outflow tract related aging with congenital heart defects: identifying causes and mechanisms of myocardial and large vessel wall adaptation, predictors for long term outcome and targets for improved treatment.
OUTREACH
Undifferentiated
Qualitative interviews with parents of children and professionals working in Youth Health Care on the topic of stressful life events, psychosocial problems and needed support.
Gender-Health
Parents
Psychosocial health
Children
Stressful life events
Excess mortality during the Covid-19 epidemic: vulnerable groups and long-term effects
Excess mortality
The clinical data supporting the findings of this study are available in this online data repository and can be made available upon reasonable request. The data are sensitive since they involve personal information of patients. There are also restrictions on use by commercial parties, and on sharing openly based on (inter)national laws and regulations and written informed consent. Therefore these data (and additional clinical data) are only available upon signing a Data Transfer Agreement (see Terms of Access).
Replication Data for: DUET-Study
Urological complications
Double-J Stenting
Kidney Transplantation
collection type: Cohort,Disease specific,Hospital,Longitudinal | disease: Ischaemic heart diseases | data categories: Medical records,Physiological/Biochemical measurements,Survey data | materials: Not available | omics: Not available | imaging: N | sex: Female,Male
BENEFIT is an ecosystem for healthy living and an integrated loyalty program that rewards patients for the time and energy spent on healthy lifestyle activities. By rewarding everyday lifestyle and adherence behaviors, the program integrates care and non-care settings and facilitates embedding the new lifestyle in everyday life.
BENEFIT for all: The Ecosystem for Healthy Living
Ischaemic heart diseases
BENEFIT
De neurobiologische basis van aanhoudende Vermoeidheid en Cognitieve klachten na COVID-19
collection type: Other | disease: Other specified degenerative diseases of nervous system | data categories: Imaging data | materials: Not available | omics: Not available | imaging: Y | sex: Female,Male
To optimally use brain imaging data in vascular cognitive impairment (VCI), the ImProVas project (i) develops and validates methods for automatic quantification of microbleeds and lacunar infarcts and (ii) develops and validates prediction methods utilizing these biomarkers. The project extends existing cohorts with novel image-derived biomarkers (HBC: https://www.ncbi.nlm.nih.gov/pubmed/29017156; TRACE-VCI: https://www.ncbi.nlm.nih.gov/pubmed/28428166).
Improved Prognosis of Vascular cognitive impairment using automatic quantitative imaging biomarker extraction and disease modeling
Other specified degenerative diseases of nervous system
ImProVas
Improvise, adapt, overwork? Understanding and learning from hospitals' adaptations to COVID-19 and their effects on professional functioning and recovery
Hospital employees
Deze dataset bevat gegevens uit straatdokterpraktijken over de gezondheidstoestand van daklozen tijdens Coronapandemie
Homeless and COVID-19 lessons for the future
Homeless people
Social care
urban
collection type: Case-Control,Cohort,Disease specific,Hospital,Population-based,Rare disease collection | disease: Cardiac arrhythmia, unspecified | data categories: Biological samples,Medical records,National registries,Physiological/Biochemical measurements | materials: Buccal Swab,cDNA / mRNA,microRNA | omics: Proteomics | imaging: N | sex: Undifferentiated
To improve treatment of ventricular arrhythmias, research is conducted on many different levels: genetics, basic and clinical electrophysiology, national registries, human samples.
PREDICT2
National registries
Case-Control
Rare disease collection
cDNA mRNA
Population-based
microRNA
Cardiac arrhythmia
ANAkinra voor de behandeling van CORonavirus infectious disease 2019 op de Intensive Care (ANACOR-IC)
Pneumonia due to coronavirus disease 2019
Deze dataset bevat gegevens uit straatdokterpraktijken over de gezondheidstoestand van daklozen tijdens de Coronapandemie
DAKLOOSHEID EN CORONA
CONTROL: effectiviteit & optimalisatie van bron- en contactonderzoek om de verspreiding van SARS-CoV-2 te beperken
target group of policy interventions
Encounter for screening for COVID-19
public health
The clinical trial data files, extracted from the CRF in .sav format can request via the above points of contact
Convalescent plasma as a treatment for high-risk outpatients administered within 7 days after COVID-19 disease onset (CoVEarly)
CoVEarly
collection type: Cohort,Disease specific,Hospital | data categories: Medical records,National registries,Physiological/Biochemical measurements,Survey data | materials: Not available | omics: Not available | imaging: N | sex: Female,Male
CAPACITY is a registry of patients with COVID-19 across Europe and has been established to answer questions on the role of cardiovascular disease in this pandemic. It is an extension of the Case Record Form (CRF) that was released by the ISARIC (International Severe Acute Respiratory and Emerging Infection Consortium) and WHO (World Health Organisation) in response to the emerging outbreak of COVID-19.The aim of CAPACITY is to collect data regarding the cardiovascular history, diagnostic information and occurrence of cardiovascular complications in COVID-19 patients. By collecting this information in a standardized manner, CAPACITY can aid in providing more insight in (1) the incidence of cardiovascular complications in patients with COVID-19, and (2) the vulnerability and clinical course of COVID-19 in patients with an underlying cardiovascular disease
CAPACITY-COVID
collection type: Hospital,Longitudinal,Sample collection,Other | disease: Pneumonia due to staphylococcus aureus | data categories: Physiological/Biochemical measurements | materials: Not available | omics: Not available | imaging: N | sex: Female,Male
We investigated whether hyperaggregation occurs during infection, and whether aspirin inhibits this. Patients hospitalised due to acute infection were randomised to receive 10 days of aspirin treatment or no intervention. Our outcome measures were PFA-Closure Time, serum thromboxane and plasma thromboxane.
The efficacy of aspirin to inhibit platelet aggregation in patients hospitalised with a severe infection: a multicentre, open‑label, randomised controlled trial
ASPIRIN
Pneumonia due to staphylococcus aureus
Development of an in vivo model for long-COVID to test and identify candidate drugs
Post COVID-19 condition
Post COVID-19 infection phase
COVID-19 patient grouping with- and without post-COVID
Developed at Erasmus University Medical Center, the Breast Tumor Patient Models (BTPM) Repository consists of 22 unique breast models that are segmented into six tissues including a tumor tissue [1]. The main goal of this repository is to create a unique platform to advance the field of intact breast hyperthermia by facilitating an objective comparison of the heating quality for different hyperthermia devices using the same set of patient-derived models. The models in this repository offer a large variability of anatomical and pathological characteristics in the intact breast. Two of the models (Models 4 and 20) are also part of the ESHO benchmarks for computational modeling and optimization in hyperthermia therapy [2]. In terms of anatomical characteristics, the breast models range from small volumes (154 ml) to large volumes (1336 ml) and a mean value (591 ml). Another important anatomical characteristic, the breast density, is well covered, with three out of four breast density groups included in this database. The missing type I (almost entirely fat) breast density category is known to have a significantly lower risk of developing breast cancer, and hence does not appear in this database. In terms of pathological characteristics, all the repository models hold important variations in terms of tumor size, tumor location, and tumor depth. In terms of tumor size, the tumor volumes vary from very small 1.8 ml to 39 ml. The vast majority of tumors are stage T2 (20â50mm) tumors (18/22), but both T1 (<20 mm; 2/22) and T3 (>50 mm; 2/22) staged tumors are also present in this repository. In terms of tumor location, the current repository covers all the areas of the breast, with the most common tumor site being the upper outer region. In terms of tumor depth, the tumor sites cover all ranges from superficially positioned tumors to tumors very close to the breast base, close to the chest wall. This is evident in the large variation of tumor center to skin distance, varying from 12 to 43 mm, with an average of 26 mm. All models in the BPTM Repository were created from fully anonymized contrast enhanced MRI data of the breast cancer patients undergoing neoadjuvant chemotherapy. All models were segmented into six tissues: skin, bone, muscle, tumor, fibroglandular, and fat. Skin, thoracic bones, pectoralis major muscle, and the tumor lesion were manually contoured. The remaining tissue volume was segmented into fatty and fibroglandular tissue using an automatic segmentation method based on the voxel intensity described in Zastrow et al. [3] and Omer et al. [4].
Data for: Patient-derived breast model repository, a tool for hyperthermia treatment planning and applicator design
computational modeling
Thermotherapy
anatomical models
breast carcinoma
cancer
Nivel Primary Care General Practices 2018
The clinical trial data files, extracted from the CRF in .sav format can request via the above points of contact (2024-10-28)
Immunogenicity and reactogenicity of SARSCoV-2 vaccines in people living with HIV in the Netherlands: A nationwide prospective cohort study
HIV Mesh
COVID 19 Mesh
vaccination Mesh
Supplementary table 1 for Chapter 3 - Pathway Enrichment Analysis results Table containing all significant GO:BP terms obtained via ORA and GSEA analyses, for all analyzed comparisons. Data belongs to PhD thesis Thom Reuvers - ''Improving Peptide Receptor Radionuclide Outcomes - A Radiobiological Approach" (2024).
Supplementary table 1 for Chapter 3 - Pathway Enrichment Analysis results
Pathway Enrichment Analysis
Sociale ongelijkheid in sport en bewegen onder COVID-19
Maatschappelijke dynamiek
Changes in the use and organization of care in general practices and out-of-hours services: lessons learned from the COVID-19 pandemic
people by employment
informal care
provincial
people by socio-economic status
people with migration background
online care
people by chronic disease
Electronic health record data from general practices spread throughout the Netherlands. General practice care comprises regular healthcare provision during normal practice hours, excluding out-of-hours primary care, emergency care and hospital admissions
Nivel Primary Care General Practices 2014
Electronic Health Records
Routine Healthcare Data
Primary Care
EHR
collection type: Cross-sectional,Disease specific,Longitudinal | data categories: Survey data,Other | materials: Not available | omics: Not available | imaging: N | sex: Female,Male
The multidisciplinary ArmCoach4Stroke project aims to develop and evaluate a new and interactive therapy aid based on movement sensors to stimulate and optimize the daily use and exercise of the affected arm in the home environment by objective, personalized feedback to the patient and his/her therapist.The ArmCoach4Stroke will be developed in co-creation with patients and therapists and other (end)users, with focus on optimal implementation in health care.
ArmCoach4Stroke
Cross-sectional
This study contains data for 20 patients with enhancing and non-enhancing glioma, for internal use only. There are 3 time-points for each patient: PreOp, PostOp and Progression. PostOp is generally 3 months after surgery, with one exception where it is 3 days after surgery (P10). Segmentations have a PostFix, e.g. "En, or NonEn", relating to Enhancing, or Non-Enhancing glioma at this given time point. All segmentations are in the space of the T1c (T1 with enhancing contrast), and by one observer (from the study by Visser et al., 2019; https://doi.org/10.1016/j.nicl.2019.101727).
Seg-Ams
research
dataset
Corona-maatregelen: 'double jeopardy' voor leesprestaties van doelgroepleerlingen in het primair onderwijs?
Covid-19 measures: 'double jeopardy' for reading achievements of vulnerable pupils in primary education?
Child and adolescent mental health and wellbeing in times of the COVID-19 pandemic; Mentale gezondheid en welbevinden van de Nederlandse jeugd ten tijde van de COVID-19 pandemie
Mentale gezondheid en welbevinden van de Nederlandse jeugd ten tijde van de COVID-19 pandemie
Clinical versus general population samples
Blood vessels-on-chip to understand and target COVID-19 intravascular coagulation
Convalescent plasma as a treatment for high-risk outpatients administered within 7 days after COVID-19 disease onset (CoV-Early)
FTD-RisC (Frontotemporal Dementia Risk Cohort) is a longitudinal research study that aims to find novel biomarkers for genetic FTD. Participants include family members of mutation carriers, who have a 50% risk of being at risk of FTD. Modalities include brain MRI, blood and cerebral spinal fluid (CSF), neuropsychological testing and behavioral questionnaires. FTD-RisC is set-up in 2010 by the Department of Neurology of Erasmus MC, Rotterdam/NL.
FTD-RisC
collection type: Hospital | disease: hartfalen | data categories: Biological samples,Imaging data,Medical records,Physiological/Biochemical measurements,Survey data,Other | materials: Feaces,Other | imaging: Y | sex: Undifferentiated
We investigate diagnostic technologies to reduce cardiovascular disease. We use questionnaires, serious gaming, electrocardiography, digital stethoscopes and other eHealth techniques. Big data analytics are used to study patterns.
Self TRAcking for Prevention and diagnosis of heart disease
STRAP
hartfalen
These data are supplemental figures to the manuscript 'Standardization of TSH and FT4 to gestational age in pregnancy and associations with clinical outcomes'
Standardization of TSH and FT4 to gestational age in pregnancy and associations with clinical outcomes - supplemental figures
Pregnancy
FT4
TSH
Therapeutic inhibition of excessive lung inflammation induced by anti-SARS-CoV-2 antibodies
collection type: Disease specific,Hospital | data categories: Medical records,Physiological/Biochemical measurements | materials: Plasma,Serum | omics: Not available | imaging: N | sex: Female,Male
Investigation whether low-level, aiming for serum concentrations 0.5-0.9ng/mL, digoxin on top of standard treatment (guideline-recommended therapy), is beneficial in HF patients with reduced or mid-range ejection fractions (LVEF ≤50%); in a double-blind placebo controlled clinical trial.
Digoxin Evaluation in Chronic heart failure: Investigational Study In Outpatients in the Netherlands
DECISION
Aanhoudende klachten na COVID-19 infectie: epidemiologie, pathofysiologie, predictie, en communicatie, de CORona Follow Up (CORFU) studie
long COVID
in- and outpatient rehabilitation care
no care setting but daily living
Interventie implementatie op beleids- en organisatieniveau in verschillende arbeidsorganisaties gericht op een duurzame gedragsverandering, vanuit eigen regie, voor het bevorderen van de mentale vitaliteit van werkenden.
Patiënten (kinderen en volwassenen) die een congenitale cardiochirurgische ingreep hebben ondergaan.
De congenitale cardiothoracale chirurgie registratie omvat alle uitgevoerde congenitale cardiochirurgie ingrepen bij kinderen en volwassenen.
Congenitale cardiothoracale chirurgie
CCTC
quality registry
congenital heart disease CHD
open-heart surgery
heart
congenital cardiac surgery
Mobility- and behavior-based Early-Warning System after the first wave of COVID-19
not applicable
Genetic Risk factors for Multi-system Inflammatory Syndrome in Children and Pediatric post COVID condition (GRIP)
Genetic Risk factors for Multi-system Inflammatory Syndrome in Children and Pediatric post COVID condition
Multisystem inflammatory syndrome
Online academisch onderwijs als gevolg van COVID-19 crisis: Voor wie werkt het (niet) en welke factoren kunnen dit verklaren?
education
This multi-center research project focuses on assessing and understanding the contribution of hemodynamic changes to vascular cognitive impairment (VCI).
CVON Hart-Brein
A double-blind, placebo-controlled randomized clinical trial with valsartan for PRevention of Acute rEspiraTORy dIstress syndrome in hospitAlized patieNts with SARS-COV-2 Infection Disease
Hartwig Medical Foundation whole transcriptome sequencing dataset. The Hartwig Medical Database is a continuously growing resource containing whole genome and whole transcriptome sequencing data. This is the largest database of metastatic tumor data obtained with WGS in the world. The uniqueness of the database consists of combining genetic data with treatment and treatment outcome data. The incidence of solid tumors in the Netherlands is reflected in the quantity and frequency of the tumor types in the database. In addition to molecular data, the database also contains an ever-growing list of tumor clinical characteristics. Our processes are standardized from sample preparation to patient reporting assuring a highly consistent dataset.
Cancer Whole Transcriptome Sequencing
Whole transcriptome sequencing
Kansen in Crisis: Hoe geven scholen vorm aan educatief partnerschap?; Chances in Crisis: How do schools shape school-family partnerships?
Kansen in Crisis: Hoe geven scholen vorm aan educatief partnerschap?
effects on society resilience of schools
Crohn's disease (CD) is an inflammatory bowel disease (IBD). Several drugs exist to induce and maintain remission, but a significant part of the patients is refractory to current IBD drugs or experiences side effects. Whether low-dose naltrexone (LDN) is a safe and easily accessible alternative treatment option for these patients needs to be investigated. The aim of this study is to assess the efficacy of LDN for the induction of remission in patients with mild to moderate CD. The LDN Crohn study is a randomised, double-blinded, placebo-controlled multicentre trial. Patients with CD are randomised 1:1 to receive treatment with either LDN 4.5 mg once daily or placebo for 12 weeks. The primary objective is endoscopic remission at week 12, defined as Simple Endoscopic Score-CDâ¤2 and ulcerated surface subscore â¤1 in all five segments. Secondary aims include clinical and endoscopic response, changes in laboratory measures of inflammation, adverse events and patient-reported outcomes.
A preliminary study of Low Dose Naltrexone for the induction of remission in patients with mild to moderate Crohn's Disease that failed conventional treatment: the LDN Crohn study.
These files contain the MATLAB code and data required to reproduce Figure 2-5 and Supplementary Figures S1-S4 of "Different mechanisms of contextual inference govern associatively learned and sensory-evoked postural responses". The Data folder contains .mat files with all trials of participants from group 1, 2, and 3 separately. Data includes the whole-body angle, forces and moments on the force plate, raw EMG data. Processing code is provided as 'main_classcal_conditioning.m', which performs EMG filtering, normalizing, calculation of derivatives. The file 'generate_figures' generates all figures. Note that minor aesthetic changes were made to the figures that appear in the manuscript.
Data and code for "Different mechanisms of contextual inference govern associatively learned and sensory-evoked postural responses"
postural responses
balance control
classical conditioning
unconscious processing
sensorimotor incongruence
perceptual awareness
This dataset includes the absolute numbers of all first and second choice antibiotics that qualify for respiratory tract infections in primary care according to the Dutch antibiotic guidelines. The following selection of antibiotics are included: Doxycycline, Amoxicillin, Augmentin, Phenoxymethylpenicillin, Macrolides, and Pheneticillin. The prescribed antibiotics are linked to individual general practitioners from three Dutch cities: The Hague, Rotterdam and Amsterdam. In the dataset we also included the number of prescribed antibiotics for all infections (regardless of the indication) per individual general practitioner. All data refer to antibiotics that are prescribed within primary care. The data was collected during multiple winter months: November 2018 â April 2019; November 2019 â April 2020; November 2020 â April 2021; November 2021 â April 2022. The data only contains numbers about the antibiotic prescription behavior of the Dutch general practitioners and no individual background characteristics of the general practitioners.
Prescription of antibiotics for respiratory tract infections by Dutch general practitioners
antibiotics primary care general practioner prescription behavior
This dataset contains transcripts of interviews with 14 general practitioners, doctor' s assistants and support staff from general practices on the implementation and effectiveness of synchronous chat in general practice.
Implementation and evaluation of synchronous chat in general practice
electronic consultations
general practice
digital health technologies
implementation
Erasmus Glioma Database (EGD). Collection of patients with adult-type diffuse glioma from the Erasmus MC, for internal use only. Per patient one or multiple MRI scan sessions are available. Also, if known, the following information is available: male/female, year of birth, tumour grade, whether enhancement is seen, whether 1p19q is codeleted, whether IDH is mutated, whether MGMT promotor is methylated, whether there is a gain in chr7 and loss in chr10, whether there is a gain in chr19 and chr20, whether there is TERT promotor mutation, whether ATRX is mutated, whether EGFR is amplified and the date of first operation. A sub-selection of patients has been included in the published EGD (van der Voort et al., 2021; https://doi.org/10.1016/j.dib.2021.107191), but these patients have been anonymised and so there is no link between the patients in the published EGD and this current database.
Erasmus Glioma Database
tumour
tumor
brain
glioma
Rouwen in Coronatijden: mogelijkheden, beperkingen en kansen om gecompliceerde rouw bij nabestaanden te voorkomen: beschrijvend onderzoek en implementeren.
no care setting general population
none
Metadata of retrospective medical data and pathological data of Head and Neck oncology adult patients from the Erasmus Medical Center in Rotterdam. Patients including from jan-2006 till dec-2023 and still ongoing. Number of patients included today (18-12-2023) : 7571 (Male: 5353, Female: 2216; 2 unknown)
Metadata of Rotterdam Oncology Documentation (RONCDOC)
Head and Neck Neoplasms
Een onverwachte valse start op de arbeidsmarkt
Effects COVID on participation
This dataset contains transcripts of interviews with 16 patients with low socioeconomic status on their experiences with accessibility and quality of general practice care.
Accessibility and perceived quality of GP care for socioeconomically disadvantaged patients
quality of care
socioeconomic status
accessibility
The dataset is made available and consists of two partitions, a training and a testing dataset. The training dataset contains 625 annotated patches (from 20 images from 18 subjects) and the testing dataset contains 54 annotated patches (from 18 images from 18 subjects). The testing dataset contains annotations from four different graders. Further information about the annotations can be found in paper. Training: The training image patches are individual .tiff files with the dimension of (128x128 pixels). Use any tiff-reader you want. Test: The test image patches and annotations are .tiff files with the dimensions of (3x128x128). NOTE: Need to be loaded using imageio.mimread() Link to code: https://gitlab.com/radiology/eye/ao-vision/ao-fio-conedetect Python to load the image files. import imageio import tifffile # Training-dataset images image_training_path = "path/to/data/image.tiff" image_array = tifffile.imread(image_training_path) # Test-dataset images image_test_path = "path/to/data/image.tiff" image_array = imageio.mimread(image_test_path) # Not using mimread will lead to wrong loading of the tiff-file
Replication Data for: Automated Cone Photoreceptors Detection in Adaptive Optics Flood-Illumination Ophthalmoscopy
Cone photoreceptors detection
collection type: Cross-sectional,Disease specific,Image collection | disease: Cardiomyopathy | data categories: Biological samples,Imaging data,Medical records,Physiological/Biochemical measurements,Survey data | materials: Serum,Whole Blood | omics: Not available | imaging: Y | sex: Female,Male,Undifferentiated
We collected cardiac data (history, phusica; examination, Echo, ECG, Blood) from 1550 chidlhood cancer survivors and 250 sibling.
Early detection of cardiac dysfunction in childhood cancer survivors; a LATER study
Cardiomyopathy
Whole Blood
LATER CARD
Transcripts of interviews performed with patients with HIV that visit the HIV outpatient clinic of the Erasmus MC on their experiences with the implementation of a generic quality of life questionnaire and the change in consultation schedule and structure
Patient experiences with value-based healthcare interventions at the HIV outpatient clinic of the Erasmus Medical Centre
Netherlands
Quality of life
Remote Consultation
Ambulatory Care Facilities
This dataset contains interview transcriptions of interviews with 13 GPs on their experiences with communication with patients from different cultural backgrounds and/or low socio-economic status
The experiences of general practitioners regarding communication with patients from different cultural backgrounds and/or low socio-economic status
communication
cultural background
The dataverse contains supportive flow cytometric, proteomic, histochemical, transcriptomics and clinical data for the research article: Maud Heredia, et al., Gut-homing and intestinal TIGITnegCD38+ memory T cells acquire an IL-12-induced, ex-Th17 pathogenic phenotype in a subgroup of Crohnâs disease patients with a severe disease course. Mucosal Immunol. 2024 Nov 24:S1933-0219(24)00116-8. doi: 10.1016/j.mucimm.2024.11.008.
Data for "Gut-homing and intestinal TIGITnegCD38+ memory T cells acquire an IL-12-induced, ex-Th17 pathogenic phenotype in a subgroup of Crohn's disease patients with a severe disease course"
Intestinal T cells
Mucosal Immunology
IL-12
De maatschappelijke impact van COVID-19; The societal impact of COVID-19
The societal impact of COVID-19
Long-term mental health trajectories in recovered Covid-19 patients.
Infectious disease
Sniffing out Covid: Perspective for patients with persisting loss of smell, towards better understanding and treatment
Vulnerable in Amsterdam: The organisation and effects of support to vulnerable groups during and after the corona-crisis
people with psychiatric vulnerabilities
homeless
street care
sex workers