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items per page: 100
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total items: 484

Amsterdam University Medical Centers
type: Agent

Alrijne Ziekenhuis
type: Agent

Antonius Ziekenhuis
type: Agent

Bravis Ziekenhuis
type: Agent

Catharina Ziekenhuis
type: Agent

Diakonessenhuis hospital
type: Agent

Haga Hospital
type: Agent

IJsselland Ziekenhuis
type: Agent

Isala
type: Agent

Maastricht University Medical Centre
type: Agent

Meander Medisch Centrum
type: Agent

Medisch Centrum Leeuwarden
type: Agent

Ziekenhuis Nij Smellinghe
type: Agent

National Institute for Public Health and the Environment
type: Agent

Radboud University Medical Center
type: Agent

Spaarne Gasthuis
type: Agent

St. Antonius Ziekenhuis
type: Agent

Tergooi
type: Agent

Tjongerschans
type: Agent

University Medical Center Groningen
type: Agent

Wilhelmina Children's Hospital
type: Agent

Ziekenhuis Groep Twente
type: Agent

ZorgSaam
type: Agent

http://catalogue.hdsu.nl/catalogue-rdf/api/rdf/Contacts/firstName=BioDay&lastName=ContactEmail&resource=BioDay
type: Kind
fn: BioDay ContactEmail

http://catalogue.hdsu.nl/catalogue-rdf/api/rdf/Contacts/firstName=EPIC-NL&lastName=Study%20team&resource=EPIC-NL
type: Kind
fn: EPIC-NL Study team

http://catalogue.hdsu.nl/catalogue-rdf/api/rdf/Contacts/firstName=Gijs&lastName=Aertssen&resource=HEM-PRO
type: Kind
fn: Gijs Aertssen

http://catalogue.hdsu.nl/catalogue-rdf/api/rdf/Contacts/firstName=Hester&lastName=de%20Groot-Kruseman&resource=ALL10
type: Kind
fn: Hester de Groot-Kruseman

http://catalogue.hdsu.nl/catalogue-rdf/api/rdf/Contacts/firstName=Hester&lastName=de%20Groot-Kruseman&resource=ALL11
type: Kind
fn: Hester de Groot-Kruseman

http://catalogue.hdsu.nl/catalogue-rdf/api/rdf/Contacts/firstName=Olaf&lastName=Cremer&resource=MARS%20-%20Molecular%20Diagnosis%20and%20Risk%20Stratification%20of%20Sepsis
type: Kind
fn: Olaf Cremer

http://catalogue.hdsu.nl/catalogue-rdf/api/rdf/Contacts/firstName=Patricia&lastName=Bruijning-Verhagen&resource=VIOOL
type: Kind
fn: Patricia Bruijning-Verhagen

http://catalogue.hdsu.nl/catalogue-rdf/api/rdf/Contacts/firstName=Sander&lastName=van%20der%20Laan&resource=Athero-Express
type: Kind
fn: Sander van der Laan
has URL: vanderlaanscience.nl']

http://catalogue.hdsu.nl/catalogue-rdf/api/rdf/Contacts/firstName=Sarah%20Luna&lastName=Dijkstra&resource=The%20TWIN-study
type: Kind
fn: Sarah Luna Dijkstra

http://catalogue.hdsu.nl/catalogue-rdf/api/rdf/Contacts/firstName=Secretariaat&lastName=JHN&resource=Julius%20Huisartsen%20Netwerk
type: Kind
fn: Secretariaat JHN

http://catalogue.hdsu.nl/catalogue-rdf/api/rdf/Contacts/firstName=Sofie&lastName=Gernaat&resource=UMBRELLA
type: Kind
fn: Sofie Gernaat

Protocol ALL 10, protocol voor diagnostiek en behandeling van kinderen en adolescenten (1-19 jaar) met Acute Lymfatische Leukemie (ALL)
type: Dataset
applicable legislation: oj
number of unique individuals: 778
access rights: NON PUBLIC
accrual periodicity: NEVER
creator: Princess Máxima Center
description: The aim of Protocol ALL-10 is to improve the overall treatment results in terms of EFS and to decrease treatment intensity in patients with a pEFS of >95%. Therapy will be tailored according to the risk of relapse as determined by the MRD levels at 2 time points during the first months of therapy. This tailored therapy should lead to less intensive therapy for patients with low risk of relapse and to intensification of therapy for patients with medium and high risk of relapse.
issued: 2026-02-25T07:45:46.145024
modified: 2026-05-13T11:33:50.271121
provenance: ProvenanceStatement
  label: The aim of Protocol ALL-10 is to improve the overall treatment results in terms of EFS and to decrease treatment intensity in patients with a pEFS of >95%. Therapy will be tailored according to the risk of relapse as determined by the MRD levels at 2 time points during the first months of therapy. This tailored therapy should lead to less intensive therapy for patients with low risk of relapse and to intensification of therapy for patients with medium and high risk of relapse.
publisher: Princess Máxima Center
spatial: NLD
contact point: http://catalogue.hdsu.nl/catalogue-rdf/api/rdf/Contacts/firstName=Hester&lastName=de%20Groot-Kruseman&resource=ALL10
keyword: Acute Lymfatische Leukemie
theme: HEAL

PROTOCOL ALL 11: Treatment study protocol of the Dutch Childhood Oncology Group for Children and adolescents (1-19 year) with newly diagnosed acute lymphoblastic leukemia
type: Dataset
applicable legislation: oj
number of unique individuals: 887
access rights: NON PUBLIC
creator: Princess Máxima Center
description: 1. To improve the overall outcome as compared to the previous protocols of the DCOG, especially ALL-9 and ALL-10. This is aimed for by decreasing therapy for part of the patients (TEL/AML1, Down syndrome, PPR only), increasing therapy for IKZF1 mutated cases, decreasing the cumulative dose of anthracyclines, omitting cranial irradiation and total body irradiation and individualizing asparaginase therapy for all patients. 2. Does a continuous schedule of Asparaginase lead to less allergic reaction/inactivation of Asparaginase than the standard non continuous schedule of Asparaginase? Patients are randomized to receive noncontinuous PEGasparaginase in IA (induction) and intensification of the Medium Risk group (standard arm A) or to receive continuous PEGasparaginase in IA, IB, M and intensification (continuous arm B) with the same cumulative number of doses of PEGasparaginase. 3. Does prophylactic administration of intravenous immunoglobulins reduce the number of infections during the intensive treatment phases? Patients are randomized in the induction and MR treatment group to receive or not receive prophylactic immunoglobulins. 4. Individualize the dose schedule of asparaginase by therapeutic drug monitoring in order to detect silent inactivation of asparaginase, to prevent allergic/anaphylactic reactions, to switch Asparaginase preparation in time and to prevent too high levels with possible toxicity.
issued: 2026-02-25T07:46:00.765121
modified: 2026-05-13T11:34:17.223403
provenance: ProvenanceStatement
  label: 1. To improve the overall outcome as compared to the previous protocols of the DCOG, especially ALL-9 and ALL-10. This is aimed for by decreasing therapy for part of the patients (TEL/AML1, Down syndrome, PPR only), increasing therapy for IKZF1 mutated cases, decreasing the cumulative dose of anthracyclines, omitting cranial irradiation and total body irradiation and individualizing asparaginase therapy for all patients. 2. Does a continuous schedule of Asparaginase lead to less allergic reaction/inactivation of Asparaginase than the standard non continuous schedule of Asparaginase? Patients are randomized to receive noncontinuous PEGasparaginase in IA (induction) and intensification of the Medium Risk group (standard arm A) or to receive continuous PEGasparaginase in IA, IB, M and intensification (continuous arm B) with the same cumulative number of doses of PEGasparaginase. 3. Does prophylactic administration of intravenous immunoglobulins reduce the number of infections during the intensive treatment phases? Patients are randomized in the induction and MR treatment group to receive or not receive prophylactic immunoglobulins. 4. Individualize the dose schedule of asparaginase by therapeutic drug monitoring in order to detect silent inactivation of asparaginase, to prevent allergic/anaphylactic reactions, to switch Asparaginase preparation in time and to prevent too high levels with possible toxicity.
publisher: Princess Máxima Center
spatial: NLD
contact point: http://catalogue.hdsu.nl/catalogue-rdf/api/rdf/Contacts/firstName=Hester&lastName=de%20Groot-Kruseman&resource=ALL11
keyword: Acute Lymfatische Leukemie
theme: HEAL

Athero- and Aneurysm-Express Biobank Studies
type: Dataset
applicable legislation: oj
number of unique individuals: 3500
access rights: NON PUBLIC
accrual periodicity: NEVER
creator: University Medical Center Utrecht
description: The Athero-Express Biobank Study (AE) and the Abdominal Aortic Aneurysm-Express Biobank Study (AAA) are two ongoing, prospective biobank studies initiated in 2002 and 2003, respectively. Together, they comprise detailed histological and clinical data from over 4,500 patients who underwent arterial surgery at two Dutch tertiary referral centers. The AE Biobank includes over 3,500 patients who underwent endarterectomy to remove atherosclerotic plaques, predominantly from the carotid and femoral arteries. The AAA Biobank includes over 1,000 patients who underwent open surgical repair of arterial aneurysms, primarily abdominal aortic aneurysms. For both studies, blood and vascular tissue (plaque or aneurysm wall) were collected during surgery and stored at −80℃. Tissue material is routinely processed for standardised (immuno)histochemical analysis, with histological observations performed by the same dedicated technician, ensuring consistency; interobserver analyses have been previously reported. In AE, the following plaque characteristics were quantified or scored: • Macrophages (CD68) and smooth muscle cells (α-actin) as the percentage of field area using computerised analysis. • Intraplaque vessel density (CD34) as the average count per 3 hotspots. • Intraplaque haemorrhage (IPH) was scored as absent/present using hematoxylin and eosin (HE). • Intraplaque fat was defined as < or ≥40% of total plaque area (HE). • Calcification (HE) and collagen content (picrosirius red) were scored as no/minor vs. moderate/heavy staining. • Overall plaque vulnerability was assessed following the method by Verhoeven et al. In AAA, tissue sections were stained using: • HE, EVG (elastin), picrosirius red (collagen), SMA (smooth muscle cells), CD68 (macrophages), CD3 (T cells), CD20 (B cells), CD138 (plasma cells), and von Willebrand factor (vasa vasorum). • Each marker was semiquantitatively scored from 0 to 3 (0: none, 1: minor, 2: moderate, 3: heavy), separately for the intima, media, …
issued: 2026-02-25T07:46:30.395386
modified: 2026-05-13T11:34:41.457992
provenance: ProvenanceStatement
  label: The Athero-Express Biobank Study (AE) is a longitudinal cross-sectional biobank study collecting blood and atherosclerotic plaque samples from patients undergoing endarterectomy. Clinical data is collected through standardised questionnaires and supplemented by querying electronic health records when needed. Patients are followed up to 3 years after surgery.
publisher: University Medical Center Utrecht
spatial: NLD
contact point: http://catalogue.hdsu.nl/catalogue-rdf/api/rdf/Contacts/firstName=Sander&lastName=van%20der%20Laan&resource=Athero-Express
keyword: aneurysm
keyword: arterial endarterectomy
keyword: atherosclerosis
keyword: plaque
landing page: http://www.atheroexpress.nl
theme: HEAL

BioDay Registry
type: Dataset
applicable legislation: oj
number of unique individuals: 2295
access rights: NON PUBLIC
accrual periodicity: AS NEEDED
creator: Antonius Ziekenhuis
creator: Bravis Ziekenhuis
creator: Catharina Ziekenhuis
creator: Diakonessenhuis hospital
creator: Haga Hospital
creator: IJsselland Ziekenhuis
creator: Isala
creator: Maastricht University Medical Centre
creator: Meander Medisch Centrum
creator: Medisch Centrum Leeuwarden
creator: Ziekenhuis Nij Smellinghe
creator: Radboud University Medical Center
creator: Spaarne Gasthuis
creator: St. Antonius Ziekenhuis
creator: Tergooi
creator: Tjongerschans
creator: University Medical Center Groningen
creator: University Medical Center Utrecht
creator: Wilhelmina Children's Hospital
creator: ZorgSaam
description: The BioDay registry is a disease or condition registry for atopic dermatitis (AD)/prurigo nodularis (PN). All patients treated with advanced systemic therapy (biologics and JAK inhibitors [JAKi]) for AD are eligible for inclusion in the prospective, multicenter, observational BioDay registry. Patients are treated in a daily practice setting and the choice of treatment is determined by shared decision making and according to the Dutch AD guidelines. During all visits both clinical outcomes (e.g. EASI, IGA) and patient reported outcomes (e.g. NRS itch, DLQI,ADCT/RECAP) are collected.
issued: 2026-02-25T07:45:50.884274
modified: 2026-05-13T11:34:00.048651
provenance: Multicenter prospective observational atopic dermatitis registry
publisher: University Medical Center Utrecht
spatial: http://catalogue.hdsu.nl/CatalogueOntologies/api/rdf/Regions/name=Friesland
keyword: JAK inhibitors
keyword: abrocitinib
keyword: atopic comorbidities
keyword: atopic dermatitis
keyword: baricitinib
keyword: biologicals
keyword: daily practice
keyword: dupilumab
keyword: lebrikizumab
keyword: multicenter
keyword: prurigo nodularis
keyword: real-world evidence
keyword: registry
keyword: tralokinumab
keyword: upadacitinib
landing page: http://bioday.nl
theme: HEAL

European Prospective Investigation Into Cancer and Nutrition in the Netherlands (EPIC-NL)
type: Dataset
applicable legislation: oj
number of unique individuals: 40010
access rights: NON PUBLIC
accrual periodicity: OTHER
creator: National Institute for Public Health and the Environment
creator: University Medical Center Utrecht
description: EPIC is the European Prospective Investigation Into Cancer and Nutrition. EPIC-NL is the Dutch contribution to EPIC and comprises about 40,000 individuals prospectively followed since the early 90's. Biological samples have been stored in liquid nitrogen and repeated follow-up of the cohort has occured to obtain detailed information on lifestyle and behavioural factors and morbidity and mortality.
issued: 2026-02-25T07:46:11.464809
modified: 2026-05-13T11:34:25.569340
provenance: ProvenanceStatement
  label: At baseline, the prevalence of risk factors for chronic diseases was determined using self-administered questionnaires and a physical examination. Participants are followed up over time for changes in exposure and for the occurrence of cancer, diabetes, cardiovascular diseases, and other medical conditions. Subgroups of participants were invited for several follow-up rounds.
publisher: University Medical Center Utrecht
spatial: http://catalogue.hdsu.nl/CatalogueOntologies/api/rdf/Regions/name=Limburg
contact point: http://catalogue.hdsu.nl/catalogue-rdf/api/rdf/Contacts/firstName=EPIC-NL&lastName=Study%20team&resource=EPIC-NL
keyword: bloodsamples
keyword: cancer
keyword: cardiovascular disease
keyword: cause of death
keyword: chronic disease
keyword: diabetes
keyword: environmental exposure
keyword: lifestyle
keyword: morbidity
keyword: mortality
keyword: nutrition
landing page: https://epic.iarc.fr/centres/the-netherlands/
theme: HEAL

Long-term prosthesis survival of total hip and total knee arthroplasty in people with inherited bleeding disorders
type: Dataset
applicable legislation: oj
number of unique individuals: 192
access rights: NON PUBLIC
accrual periodicity: NEVER
creator: University Medical Center Utrecht
description: In this single center retrospective cohort study, regular care data of total knee arthroplasty and total hip arthroplasty was extracted from medical records of people with bleeding disorders who attended the Van Creveldkliniek, University Medical Center Utrecht, between 1989 and 2025. Patients with moderate or severe haemophilia A or B (FVIII/FIX <5%) or Von Willebrand’s disease (VWD) with a FVIII activity <5% were included. All types of primary THA or TKA were included. All patients were followed according to standard care. The primary outcome was time to prosthesis failure, defined as revision or indication for revision (but patients are inoperable or refuse), measured in years.
issued: 2026-05-13T09:31:29.106246
modified: 2026-05-13T11:34:05.820407
provenance: Single center retrospective cohort study,
publisher: University Medical Center Utrecht
spatial: NLD
keyword: haemophilia
keyword: joint arthroplasty
keyword: survival
keyword: total hip
keyword: total knee
theme: HEAL

Julius Huisartsen Netwerk
type: Dataset
applicable legislation: oj
number of unique individuals: 1500000
access rights: NON PUBLIC
accrual periodicity: CONT
creator: University Medical Center Utrecht
description: The Julius General Practitioners Network (JHN) is a database of primary care routine data. It is a network of approximately seventy general practices with two hundred general practitioners and over 450,000 active patients in the Utrecht area. The database contains data on more than 1.5 million patients from 1995 to the present.
issued: 2026-05-13T09:31:28.341150
modified: 2026-05-13T11:33:55.781908
provenance: Electronic Health Recors of Patients in Primary Care
publisher: University Medical Center Utrecht
spatial: http://catalogue.hdsu.nl/CatalogueOntologies/api/rdf/Regions/name=Utrecht
contact point: http://catalogue.hdsu.nl/catalogue-rdf/api/rdf/Contacts/firstName=Secretariaat&lastName=JHN&resource=Julius%20Huisartsen%20Netwerk
keyword: Electronic Health Record
keyword: General Practitioner
keyword: Primary Care
landing page: https://www.juliushuisartsennetwerk.nl
theme: HEAL

MARS - Molecular Diagnosis and Risk Stratification of Sepsis
type: Dataset
applicable legislation: oj
number of unique individuals: 17000
access rights: NON PUBLIC
accrual periodicity: NEVER
creator: Amsterdam University Medical Centers
creator: University Medical Center Utrecht
description: MARS is a multicenter prospective cohort of ICU patients aimed at developing new molecular technologies for early diagnosis and risk stratification of sepsis. MARS contains comprehensive clinical data (including admission diagnoses, comorbidities, daily treatments, medications, vital-signs, labs, and microbiology results). In addition, daily prospective adjudication of infection plausibility was performed, according to standardized definitions.
issued: 2026-02-25T07:46:18.310427
modified: 2026-05-13T11:34:29.959842
provenance: Ongoing prospective cohort and biobank of ICU patients admitted to the UMC Utrecht since 2011. The AMC was a participating center between 2011 and 2013.
publisher: University Medical Center Utrecht
spatial: http://catalogue.hdsu.nl/CatalogueOntologies/api/rdf/Regions/name=Noord-Holland
contact point: http://catalogue.hdsu.nl/catalogue-rdf/api/rdf/Contacts/firstName=Olaf&lastName=Cremer&resource=MARS%20-%20Molecular%20Diagnosis%20and%20Risk%20Stratification%20of%20Sepsis
keyword: Biobank
keyword: Biomarkers
keyword: Blood samples
keyword: Citrate
keyword: Clinical
keyword: Cohort
keyword: EDTA
keyword: Heparin
keyword: ICU
keyword: Infections
keyword: Intensive Care
keyword: Pathogen detection
keyword: Plasma
keyword: Pneumonia
keyword: Prospective
keyword: Vital signs
theme: HEAL

Twin cohort for the study of (pre)clinical Inflammatory Bowel Disease in the Netherlands: The TWIN-study
type: Dataset
applicable legislation: oj
number of unique individuals: 138
access rights: NON PUBLIC
creator: University Medical Center Utrecht
description: Inflammatory Bowel Diseases (IBD), i.e. Crohn’s Disease (CD) and Ulcerative Colitis (UC), are thought to arise in genetically susceptible individuals in the context of environmental triggers, with a potential dominant role for the interplay between the gut microbiota, and the mucosal immune system. However, the relative importance and the exact role of these factors in the pathogenesis of IBD is presently unknown. Interpretation of published research in this field is often hampered by reverse causation, and data generated in animal models cannot be directly extrapolated to the human condition. The disease is probably triggered years before the occurrence of symptoms, but currently patients are only identified when clinical disease is established. The preclinical phase of IBD might hold the key to understanding the pathogenesis of IBD and could provide a huge window of opportunity of halting or even preventing disease development. At this time, data on this phase of the disease are limited. Identifying and validating biomarkers and pathophysiological mechanisms is one of the necessary steps toward prediction, prevention and optimalization of therapy in IBD care. Unaffected twin-siblings of IBD affected individuals are at increased risk of developing IBD. Therefore, studying IBD-discordant, IBD-concordant and non-IBD-concordant twins or multiples gives the unique opportunity to 1) define mechanisms that underlie (the early development of) IBD and 2) identify and validate markers of (pre)clinical IBD.
issued: 2026-02-25T07:46:05.603630
modified: 2026-05-13T11:34:21.966743
provenance: Observational study with both a cross-sectional and longitudinal design
publisher: University Medical Center Utrecht
spatial: BEL
contact point: http://catalogue.hdsu.nl/catalogue-rdf/api/rdf/Contacts/firstName=Sarah%20Luna&lastName=Dijkstra&resource=The%20TWIN-study
keyword: Crohn s disease
keyword: cohort
keyword: concordance
keyword: ibd
keyword: twin
keyword: twins
keyword: ulcerative colitis
landing page: https://www.umcutrecht.nl/nl/wetenschappelijk-onderzoek/de-twin-studie-onderzoek-met-tweelingen-naar-chronische-ontstekingsziekten-van-de-darm-ibd
theme: HEAL

'Utrecht cohort for Multiple BReast cancer intErvention studies and Long-term evaluation' cohort
type: Dataset
applicable legislation: oj
number of unique individuals: 7700
access rights: NON PUBLIC
accrual periodicity: AS NEEDED
creator: Alrijne Ziekenhuis
creator: University Medical Center Utrecht
creator: Ziekenhuis Groep Twente
description: The prospective, multicenter ‘Utrecht cohort for Multiple BREast cancer intervention studies and Long-term evaluAtion’ (UMBRELLA) cohort, established in 2013, serves as an infrastructure for conducting randomized controlled trials to evaluate effectiveness of (innovative) cancer treatments and survivorship care for breast cancer patients and survivors. UMBRELLA includes patients with histologically proven invasive breast cancer or ductal carcinoma in situ (DCIS) referred for breast cancer treatment in multiple hospitals in the Netherlands. All UMBRELLA cohort participants consent for the collection and use of their clinical data. In addition, cohort participants can also provide consent for the longitudinal collection and use of patient-reported outcomes up to 10 years after enrolment. Last, cohort participants are also asked to provide consent to be randomized into future cohort-based trials following the Trial within Cohorts design. When conducting a cohort-based trial, all UMBRELLA cohort participants are screened for eligibility. Cohort participants assigned to the intervention arm, are offered the intervention, whereas cohort participants assigned to the control arm are not informed about the intervention and remain unaware of the trial. By combining clinical data with (long-term) patient-reported outcomes from a large prospective cohort of breast cancer patients and survivors, it is possible to effectively study a diversity of clinically relevant questions to gain further insights in the effects of breast cancer treatment and its impact on quality of life as well as to evaluate effectiveness of interventions within the breast cancer field.
issued: 2026-02-25T07:46:24.123839
modified: 2026-05-13T11:34:35.521115
provenance: ProvenanceStatement
  label: All UMBRELLA cohort participants consent for the collection and use of their clinical data. In addition, cohort participants can also provide consent for the longitudinal collection and use of patient-reported outcomes up to 10 years after enrolment. Last, cohort participants are also asked to provide consent to be randomized into future cohort-based trials following the Trial within Cohorts design. When conducting a cohort-based trial, all UMBRELLA cohort participants are screened for eligibility. Cohort participants assigned to the intervention arm, are offered the intervention, whereas cohort participants assigned to the control arm are not informed about the intervention and remain unaware of the trial.
publisher: University Medical Center Utrecht
spatial: http://catalogue.hdsu.nl/CatalogueOntologies/api/rdf/Regions/name=Zuid-Holland
keyword: Breast cancer prospective cohort multicenter quality of life
landing page: https://www.umcutrecht.nl/nl/wetenschappelijk-onderzoek/umbrella
theme: HEAL

Virus Interactions in the Respiratory Tract; a Cohort Study With Children (VIOOL)
type: Dataset
applicable legislation: oj
number of unique individuals: 228
access rights: NON PUBLIC
accrual periodicity: NEVER
creator: University Medical Center Utrecht
description: The VIOOL study is a prospective observational cohort conducted across three winter seasons (2021–2024; October–April/May) in the Netherlands. Children under 4 years of age were recruited from the community and followed for 16 weeks. Parents recorded daily symptom diaries and collected weekly nasal swabs, regardless of symptoms. Swabs were analyzed by PCR for a broad panel of common respiratory viruses. Its primary objective is to examine interactions between respiratory virus infections in young children. The study was approved by the Medical Ethics Committee of the University Medical Centre Utrecht (UMCU) and registered in the Clinical Trials Register (NL78424.041.21).
issued: 2026-02-25T07:45:56.285550
modified: 2026-05-13T11:34:10.954441
provenance: ProvenanceStatement
publisher: University Medical Center Utrecht
spatial: http://catalogue.hdsu.nl/CatalogueOntologies/api/rdf/Regions/name=Utrecht
contact point: http://catalogue.hdsu.nl/catalogue-rdf/api/rdf/Contacts/firstName=Patricia&lastName=Bruijning-Verhagen&resource=VIOOL
keyword: acute respiratory illness
keyword: coinfections
keyword: healthy children
keyword: population cohort
keyword: respiratory viruses
keyword: viral interactions
theme: HEAL

CKAN
type: Catalog
language: nl
modified: 2026-05-13T11:47:37.865738
dataset: Protocol ALL 10, protocol voor diagnostiek en behandeling van kinderen en adolescenten (1-19 jaar) met Acute Lymfatische Leukemie (ALL)
dataset: PROTOCOL ALL 11: Treatment study protocol of the Dutch Childhood Oncology Group for Children and adolescents (1-19 year) with newly diagnosed acute lymphoblastic leukemia
dataset: Athero- and Aneurysm-Express Biobank Studies
dataset: BioDay Registry
dataset: European Prospective Investigation Into Cancer and Nutrition in the Netherlands (EPIC-NL)
dataset: Long-term prosthesis survival of total hip and total knee arthroplasty in people with inherited bleeding disorders
dataset: Julius Huisartsen Netwerk
dataset: MARS - Molecular Diagnosis and Risk Stratification of Sepsis
dataset: Twin cohort for the study of (pre)clinical Inflammatory Bowel Disease in the Netherlands: The TWIN-study
dataset: 'Utrecht cohort for Multiple BReast cancer intErvention studies and Long-term evaluation' cohort
dataset: Virus Interactions in the Respiratory Tract; a Cohort Study With Children (VIOOL)

aumc
type: Agent

Amsterdam Dementia Cohort - Neuropsychological Assessment
type: Dataset
applicable legislation: oj
access rights: NON PUBLIC
creator: Amsterdam UMC
description: Data collection of the Amsterdam Dementia Cohort started in 2010 and is ongoing. All study participants undergo a standardized screening protocol for dementia. This dataset includes data on neuropsychological assessment.
issued: 2026-03-12T08:16:57.075290
language: en
modified: 2026-05-13T11:33:35.157994
provenance: ProvenanceStatement
publisher: Amsterdam UMC
contact point: Kind
  fn: Amsterdam Dementia Cohort
keyword: MRI
keyword: Alzheimer
keyword: Dementia
keyword: EEG
keyword: Imaging
keyword: MEG
keyword: Neurophysiology
qualified attribution: Attribution
  agent: Wiesje van der Flier
  had role: principalInvestigator
theme: HEAL

The nationwide HEreditary Breast and Ovarian cancer study the Netherlands (Hebon)
type: Dataset
applicable legislation: oj
access rights: NON PUBLIC
creator: Nederlands Kanker Instituut - Antoni van Leeuwenhoekziekenhuis
description: Hebon, initiated by NKI-AVL in 1997, is an active multidisciplinary collaboration of Clinical Genetics and laboratory departments of all University Medical Centers in the Netherlands and the Netherlands Cancer Institute, conducting a dynamic prospective cohort study for members of breast and ovarian cancer families. Currently 60,000 persons are enrolled. Hebon collects DNA test outcome results, self-reported risk factor data via questionnaires, pedigree data, mammography and MRI data, treatment data through linkage with the Netherlands Cancer Registry and Palga, vital status through linkage with the Dutch municipality register (BRP) and cause of death data via linkage with the Dutch Central Bureau of Statistics.
issued: 2026-05-12T09:45:05.007489
language: en
modified: 2026-05-13T11:32:43.653762
provenance: ProvenanceStatement
publisher: Nederlands Kanker Instituut - Antoni van Leeuwenhoekziekenhuis
contact point: Kind
  fn: Hebon study
keyword: Breast Cancer
keyword: Cancer Genetics
keyword: Epidemiology
keyword: Hereditary Breast and Ovarian Cancer
keyword: Ovarian Cancer
qualified attribution: Attribution
  agent: Hebon study
  had role: Originator
qualified attribution: Attribution
  agent: Marjanka K. Schmidt
  had role: principalInvestigator
theme: HEAL

Amsterdam Dementia Cohort - Biomarkers
type: Dataset
applicable legislation: oj
access rights: NON PUBLIC
creator: Amsterdam UMC
description: Plasma
issued: 2026-03-12T08:16:37.032537
language: en
modified: 2026-05-13T11:33:18.400094
provenance: ProvenanceStatement
publisher: Amsterdam UMC
contact point: Kind
  fn: Amsterdam Dementia Cohort
keyword: Alzheimer
qualified attribution: Attribution
  agent: Wiesje van der Flier
theme: HEAL

ABOARD Cohort
type: Dataset
applicable legislation: oj
access rights: NON PUBLIC
creator: Amsterdam UMC
description: Data collection of the ABOARD Cohort started in 2022 and is ongoing. Participants receive annual online questionnaires on (mental) health, quality of life, and use of healthcare resources. In addition, medical data is collected from participants that visited a physician because of (self-reported) memory problems.
issued: 2026-03-12T08:16:58.935311
language: en
modified: 2026-05-13T11:33:03.791136
provenance: ProvenanceStatement
publisher: Amsterdam UMC
contact point: Kind
  fn: ABOARD Cohort
keyword: Alzheimer
keyword: Dementia
keyword: PROMS
qualified attribution: Attribution
  agent: Wiesje van der Flier
theme: HEAL

The multitarget faecal immunochemical test for improving stool-based colorectal cancer screening programmes: a Dutch population-based, paired-design, intervention study
type: Dataset
applicable legislation: oj
access rights: NON PUBLIC
creator: Nederlands Kanker Instituut - Antoni van Leeuwenhoekziekenhuis
description: Background The faecal immunochemical test (FIT) is widely employed for colorectal cancer screening. However, its sensitivity for advanced precursor lesions remains suboptimal. The multitarget FIT (mtFIT), measuring haemoglobin, calprotectin, and serpin family F member 2, has demonstrated enhanced sensitivity for advanced neoplasia, especially advanced adenomas, at equal specificity to FIT. This study aimed to prospectively validate and investigate the clinical utlitity of mtFIT versus FIT in a setting of population-based colorectal cancer screening. Methods Individuals aged 55–75 years and who were eligible for the Dutch national FIT-based colorectal cancer screening programme were invited to submit both a FIT and mtFIT sample collected from the same bowel movement. Positive FIT (47 μg/g haemoglobin cutoff) or mtFIT (based on decision-tree algorithm) led to a colonoscopy referral. The primary outcome was the relative detection rate of mtFIT versus FIT for all advanced neoplasia. Secondary outcomes were the relative detection rates of colorectal cancer, advanced adenoma, and advanced serrated polyps individually and the long-term effect of mtFIT-based versus FIT-based programmatic screening on colorectal cancer incidence, mortality, and cost, determined with microsimulation modelling. The study has been registered in ClinicalTrials.gov, NCT05314309, and is complete. Findings Between March 25 and Dec 7, 2022, 35786 individuals were invited to participate in the study, of whom 15283 (42·7%) consented, and 13187 (86·3%) of 15283 provided both mtFIT and FIT samples with valid results. Of the 13187 participants, 6637 (50·3%) were male and 6550 (49·7%) were female. mtFIT showed a 9·11% (95% CI 8·62–9·61) positivity rate and 2·27% (95% CI 2·02–2·54) detection rate for advanced neoplasia, compared with a positivity rate of 4·08% (3·75–4·43) and a detection rate of 1·21% (1·03–1·41) for FIT. Detection rates of mtFIT versus FIT were 0·20% (95% CI 0·13–0·29) versus 0·17% (0·11–…
issued: 2026-03-12T08:16:43.481229
language: en
modified: 2026-05-13T11:33:11.976938
provenance: ProvenanceStatement
publisher: Nederlands Kanker Instituut - Antoni van Leeuwenhoekziekenhuis
contact point: Kind
  fn: Gerrit Meijer
keyword: Adenoma
keyword: Colorectal Neoplasms
keyword: Defecation
keyword: Early Detection of Cancer
keyword: Hemoglobins
keyword: Humans
qualified attribution: Attribution
  agent: Gerrit Meijer
qualified attribution: Attribution
  agent: Manon Spaander
qualified attribution: Attribution
  agent: Evelien Dekker
theme: HEAL

Metastatic Colorectal Cancer Treatment Response Evaluation by Ultra-Deep Sequencing of Cell-Free DNA and Matched White Blood Cells
type: Dataset
applicable legislation: oj
access rights: NON PUBLIC
creator: Nederlands Kanker Instituut - Antoni van Leeuwenhoekziekenhuis
description: Purpose: Circulating tumor DNA (ctDNA) has the potential to guide therapy selection and monitor treatment response in patients with metastatic cancer. However, germline and clonal hematopoiesis–associated alterations can confound identification of tumor-specific mutations in cell-free DNA (cfDNA), often requiring additional sequencing of tumor tissue. The current study assessed whether ctDNA-based treatment response monitoring could be performed in a tumor tissue–independent manner by combining ultra-deep targeted sequencing analyses of cfDNA with patient-matched white blood cell (WBC)-derived DNA. Experimental Design: In total, 183 cfDNA and 49 WBC samples, along with 28 tissue samples, from 52 patients with metastatic colorectal cancer participating in the prospective phase III CAIRO5 clinical trial were analyzed using an ultra-deep targeted sequencing liquid biopsy assay. Results: The combined cfDNA and WBC analysis prevented false-positives due to germline or hematopoietic variants in 40% of patients. Patient-matched tumor tissue sequencing did not provide additional information. Longitudinal analyses of ctDNA were more predictive of overall survival than standard-of-care radiological response evaluation. ctDNA mutations related to primary or acquired resistance to panitumumab were identified in 42% of patients. Conclusions: Accurate calling of ctDNA mutations for treatment response monitoring is feasible in a tumor tissue–independent manner by combined cfDNA and patient-matched WBC genomic DNA analysis. This tissue biopsy-independent approach simplifies sample logistics and facilitates the application of liquid biopsy ctDNA testing for evaluation of emerging therapy resistance, opening new avenues for early adaptation of treatment regimens.
issued: 2026-03-12T08:16:41.394031
language: en
modified: 2026-05-13T11:33:44.884268
provenance: ProvenanceStatement
publisher: Nederlands Kanker Instituut - Antoni van Leeuwenhoekziekenhuis
contact point: Kind
  fn: Nederlands Kanker Instituut - Antoni van Leeuwenhoekziekenhuis
keyword: Cell-Free Nucleic Acids
keyword: Circulating Tumor DNA
keyword: Colonic Neoplasms
keyword: High-Throughput Nucleotide Sequencing
keyword: Humans
keyword: Mutation
keyword: Neoplasm DNA
keyword: Prospective Studies
keyword: Rectal Neoplasms
keyword: Tumor Biomarkers
qualified attribution: Attribution
  agent: Remond J.A. Fijneman
  had role: principalInvestigator
theme: HEAL

Amsterdam Dementia Cohort - Neuroimaging & Neurophysiology
type: Dataset
applicable legislation: oj
access rights: NON PUBLIC
creator: Amsterdam UMC
description: Data collection of the Amsterdam Dementia Cohort started in 2010 and is ongoing. All study participants undergo a standardized screening protocol for dementia. This dataset includes data on neuroimaging-and neurophysiology data including MRI, EEG, and MEG.
issued: 2026-03-12T08:16:54.538506
language: en
modified: 2026-05-13T11:33:24.980345
provenance: ProvenanceStatement
publisher: Amsterdam UMC
contact point: Kind
  fn: Amsterdam Dementia Cohort
keyword: Alzheimer
keyword: Dementia
keyword: EEG
keyword: Imaging
keyword: MEG
keyword: MRI
keyword: Neurophysiology
qualified attribution: Attribution
  agent: Wiesje van der Flier
theme: HEAL

Amsterdam Dementia Biobank
type: Dataset
applicable legislation: oj
number of records: 232929
number of unique individuals: 10460
access rights: NON PUBLIC
creator: Amsterdam UMC
description: The Amsterdam Dementia Cohort was established in 2000, along with the foundation of the VU University Medical Center (VUmc) Alzheimer Center in the Netherlands. All patients that visit the Alzheimer Center are asked to consent to the use of their clinical data for scientific purposes. This population of patients comprises the Amsterdam Dementia Cohort, which consisted of almost 8,000 patients as of the 1st of January, 2021. After a baseline visit, the majority of patients visit the clinic annually for follow-up.
issued: 2026-03-12T08:16:38.931577
language: en
modified: 2026-05-13T11:33:30.386513
provenance: ProvenanceStatement
publisher: Amsterdam UMC
temporal: PeriodOfTime
  end date: 2017-01-01T01:00:00+00:00
contact point: Kind
  fn: Amsterdam UMC Biobank
keyword: Alzheimer
keyword: Biobank
keyword: Dementia
keyword: Samples
qualified attribution: Attribution
  agent: Wiesje van der Flier
qualified relation: Relationship
  relation: https://orcid.org/0000-0002-9448-1727
  had role: https://orcid.org/0000-0002-9448-1727
theme: HEAL

Amsterdam Dementia Cohort - Demographics & Neurological/Physical Examination
type: Dataset
applicable legislation: oj
access rights: NON PUBLIC
creator: Amsterdam UMC
description: Data collection of the Amsterdam Dementia Cohort started in 2010 and is ongoing. All study participants undergo a standardized screening protocol for dementia. This dataset includes data on demographics and neurological-and physical examination.
issued: 2026-03-12T08:16:52.942342
language: en
modified: 2026-05-13T11:32:57.315770
provenance: ProvenanceStatement
publisher: Amsterdam UMC
contact point: Kind
  fn: Amsterdam Dementia Cohort
keyword: Alzheimer
keyword: Dementia
keyword: Demographics
qualified attribution: Attribution
  agent: Wiesje van der Flier
  had role: principalInvestigator
theme: HEAL

Health-RI cBioPortal: CAIRO5 (Clinical Cancer Res 2023)
type: Distribution
format: HTML
issued: 2026-05-13T11:33:32.950246
language: en
license: naamsvermelding niet commercieel gelijk delen40
modified: 2026-05-13T11:33:32.921851
rights: RightsStatement
rights: naamsvermelding niet commercieel gelijk delen40
access URL: https://cbioportal.health-ri.nl/study/summary
byte size: 1000000

EGA: Tissue DNA, WBC DNA and cfDNA (deep-)sequencing of mCRC patients treated with doublet chemotherapy and anti-EGFR in the CAIRO5 study.
type: Distribution
format: TAR GZ
issued: 2026-05-13T11:33:37.982298
language: en
license: naamsvermelding niet commercieel gelijk delen40
modified: 2026-05-13T11:33:37.957033
rights: RightsStatement
rights: naamsvermelding niet commercieel gelijk delen40
access URL: https://ega-archive.org/studies/EGAS00001006695
byte size: 15000000000000

HEreditary Breast and Ovarian cancer study the Netherlands (Hebon)
type: Distribution
format: HTML
issued: 2026-05-13T11:32:43.678224
language: en
license: niet open
modified: 2026-05-13T11:32:43.662794
rights: RightsStatement
rights: 2023-HOP-Verklaring.pdf
access URL: https://www.hebon.nl/hop-application/
byte size: 1000000000

mtFIT, Lancet Oncol 2024 codebook
type: Distribution
format: CSV
issued: 2026-05-13T11:33:06.382952
language: en
license: https://creativecommons.org/licenses/by/4.0/
modified: 2026-05-13T11:33:06.365092
rights: RightsStatement
rights: https://creativecommons.org/licenses/by/4.0/
access URL: https://healthri.sharepoint.com/sites/Codebooks2025/Shared%2520Documents/Forms/AllItems.aspx
byte size: 53000

Health-RI cBioPortal: mtFIT (Lancet Oncol 2024)
type: Distribution
format: HTML
issued: 2026-05-13T11:33:12.003331
language: en
license: naamsvermelding niet commercieel gelijk delen40
modified: 2026-05-13T11:33:11.983375
rights: RightsStatement
rights: naamsvermelding niet commercieel gelijk delen40
access URL: https://cbioportal.health-ri.nl/study/summary
byte size: 1000000

CAIRO5, Clin Cancer Res 2023 codebook
type: Distribution
format: XLSX
issued: 2026-05-13T11:33:44.934945
language: en
license: https://creativecommons.org/licenses/by/4.0/
modified: 2026-05-13T11:33:44.891868
rights: RightsStatement
rights: https://creativecommons.org/licenses/by/4.0/
access URL: https://healthri.sharepoint.com/sites/Codebooks2025/Shared%2520Documents/Forms/AllItems.aspx
byte size: 30000

Colchicin in patients with chronic coronary disease
type: Dataset
applicable legislation: oj
population coverage: collection type: Disease specific,Hospital,Sample collection | disease: ICD 125* Chronic Coronary Disease | data categories: Biological samples,Imaging data,Medical records | materials: Serum | omics: Proteomics | imaging: Y | sex: Female,Male
access rights: RESTRICTED
creator: Dutch Cardiovascular Alliance (DCVA)
description: Double blind randomised clinical trial with colchicin/ placebo in patients with chronic coronary disease. 5552 Pts in Netherlands and Australia
issued: 2016-10-01T00:00:00+00:00
language: en
modified: 2026-05-13T11:44:25.993825
provenance: ProvenanceStatement
publisher: Dutch Cardiovascular Alliance (DCVA)
spatial: NLD
temporal: PeriodOfTime
  end date: 2020-02-14T00:00:00+00:00
  start date: 2016-10-01T00:00:00+00:00
contact point: Kind
  fn: DCVA
  has URL: ']
keyword: Biological samples
keyword: Disease specific
keyword: Female
keyword: Hospital
keyword: ICD 125 Chronic Coronary Disease
keyword: Imaging data
keyword: LoDoCo2
keyword: Male
keyword: Medical records
keyword: Proteomics
keyword: Sample collection
keyword: Serum
qualified attribution: Attribution
  agent: Dutch Cardiovascular Alliance (DCVA)
theme: HEAL

Continuous monitoring of short-term variability of repolarization for prediction and prevention of ventricular arrhythmias and sudden cardiac death.
type: Dataset
applicable legislation: oj
max typical age: 2
min typical age: 1
population coverage: collection type: Other | disease: Sudden cardiac death, so described | data categories: Physiological/Biochemical measurements | materials: Not available | omics: Not available | imaging: N | sex: Female,Male
access rights: RESTRICTED
creator: Dutch Cardiovascular Alliance (DCVA)
description: We propose a new treatment methodology that 1) is able to predict an upcoming ventricular tachy-arrhythmic event and 2) can initiate a preventive intervention. This methodology can be built into an ICD and uses beat-to-beat variability of repolarization quantified as short-term variability (STV) to continuously monitor the repolarization reserve of the heart. When a ventricular arrhythmia is forthcoming, this algorithm can activate the ICD to temporarily pace the heart at a higher frequency, thereby restoring/improving the repolarization strength of the heart and preventing the arrhythmia from occurring.
issued: 2018-11-01T00:00:00+00:00
language: en
modified: 2026-05-13T11:47:11.805911
provenance: ProvenanceStatement
publisher: Dutch Cardiovascular Alliance (DCVA)
spatial: NLD
temporal: PeriodOfTime
  end date: 2021-11-01T00:00:00+00:00
  start date: 2018-11-01T00:00:00+00:00
contact point: Kind
  fn: DCVA
  has URL: ']
keyword: Female
keyword: Male
keyword: Not available
keyword: Other
keyword: Physiological Biochemical measurements
keyword: STV 24 7
keyword: Sudden cardiac death
keyword: so described
qualified attribution: Attribution
  agent: Dutch Cardiovascular Alliance (DCVA)
theme: HEAL

CVON-AI - Catalysing the application of Artificial Intelligence for Cardiovascular Research Netherlands
type: Dataset
applicable legislation: oj
population coverage: collection type: Other | disease: Ischaemic heart diseases,Atrial fibrillation and flutter,Other cardiac arrhythmias | data categories: Other | materials: Not available | omics: Other | imaging: Y | sex: Female,Male
access rights: RESTRICTED
creator: Dutch Cardiovascular Alliance (DCVA)
description: CVON-AI, is a consortium involving 12 partners, established with the support of 5 previously established CVON consortia, all working with big-data. The project will build a generic AI cloud-platform to catalyse the application of AI by Dutch scientists to find novel solutions to questions in the already existing CVON consortia
issued: 2018-10-01T00:00:00+00:00
language: en
modified: 2026-05-13T11:45:00.023637
provenance: ProvenanceStatement
publisher: Dutch Cardiovascular Alliance (DCVA)
spatial: NLD
temporal: PeriodOfTime
  end date: 2021-09-30T00:00:00+00:00
  start date: 2018-10-01T00:00:00+00:00
contact point: Kind
  fn: DCVA
  has URL: ']
keyword: Atrial fibrillation and flutter
keyword: CVON-AI
keyword: Female
keyword: Ischaemic heart diseases
keyword: Male
keyword: Not available
keyword: Other
keyword: Other cardiac arrhythmias
qualified attribution: Attribution
  agent: Dutch Cardiovascular Alliance (DCVA)
theme: HEAL

Dutch national consortium to promote cardiovascular healthy ageing in women
type: Dataset
applicable legislation: oj
population coverage: collection type: Case-Control,Cohort,Cross-sectional,Image collection | disease: Atherosclerotic heart disease | data categories: Imaging data,Medical records | materials: Not available | omics: Not available | imaging: Y | sex: Female
access rights: RESTRICTED
creator: Dutch Cardiovascular Alliance (DCVA)
description: In CREW we addressed the following topics: - The prevalence of (subclinical) CVD in middle-aged women with PCOS/POI - The prevalence of (subclinical) CVD in middle-aged women with a history of PE - Migraine as determinant of stroke risk during reproductive age - VTE-risk during reproductive age
issued: 2014-06-01T00:00:00+00:00
language: en
modified: 2026-05-13T11:47:17.521015
provenance: ProvenanceStatement
publisher: Dutch Cardiovascular Alliance (DCVA)
spatial: NLD
temporal: PeriodOfTime
  end date: 2019-06-30T00:00:00+00:00
  start date: 2014-06-01T00:00:00+00:00
contact point: Kind
  fn: DCVA
  has URL: ']
keyword: Atherosclerotic heart disease
keyword: CREW
keyword: Case-Control
keyword: Cohort
keyword: Cross-sectional
keyword: Female
keyword: Image collection
keyword: Imaging data
keyword: Medical records
keyword: Not available
qualified attribution: Attribution
  agent: Dutch Cardiovascular Alliance (DCVA)
theme: HEAL

Atriumfibrilleren registratie
type: Dataset
applicable legislation: oj
health category: Q10379
population coverage: Volwassenen van 18 jaar of ouder die een eerste atriumfibrilleren of atriumflutter diagnose hebben gekregen.
access rights: RESTRICTED
accrual periodicity: ANNUAL
creator: Nederlandse Hart Registratie
description: De Atriumfibrilleren registratie omvat patiënten met de novo atriumfibrilleren en/of atriumflutter. Het betreft patiënten (18 jaar of ouder) met een eerste AF / atriumflutter diagnose, geregistreerd op een 12-kanaals ECG, een holteronderzoek (minstens 30 seconden durend) of device detected. Indien device detected dan geldt een atrial high-rate episode (AHRE) > 24u durend als inclusiecriterium.
issued: 2017-01-01T00:00:00+00:00
language: NLD
modified: 2026-05-13T11:46:51.610371
provenance: ProvenanceStatement
publisher: Nederlandse Hart Registratie
spatial: NLD
temporal: PeriodOfTime
  start date: 2017-01-01T00:00:00+00:00
contact point: Kind
  fn: NHR
  has URL: ']
keyword: atrial fibrillation
keyword: atrial flutter
keyword: cardiac rhythm
keyword: heart
keyword: quality registry
qualified attribution: Attribution
  agent: Nederlandse Hart Registratie
theme: HEAL

Pacemaker- en ICD registratie
type: Dataset
applicable legislation: oj
health category: Q10379
population coverage: Patiënten (kinderen en volwassenen) die een device en/of lead ingreep hebben ondergaan.
access rights: RESTRICTED
accrual periodicity: ANNUAL
creator: Nederlandse Hart Registratie
description: De pacemaker- en ICD registratie omvat alle ingrepen tijdens een interventie gerelateerd aan een pacemaker, ICD, implanteerbare hartmonitor (ICM) en/of bijbehorende lead(s). Het gaat hierbij om zowel implantaties, vervangingen en explantaties, als andere type ingrepen, zoals afgebroken ingrepen en reposities.
issued: 2013-01-01T00:00:00+00:00
language: NLD
modified: 2026-05-13T11:44:49.180683
provenance: ProvenanceStatement
publisher: Nederlandse Hart Registratie
spatial: NLD
temporal: PeriodOfTime
  start date: 2013-01-01T00:00:00+00:00
contact point: Kind
  fn: NHR
  has URL: ']
keyword: AV-block
keyword: CRT
keyword: ICD
keyword: ICM
keyword: device
keyword: heart
keyword: heart failure
keyword: leads
keyword: pace and ablate
keyword: pacemaker
keyword: quality registry
keyword: sick sinus syndrome
keyword: transvenous
qualified attribution: Attribution
  agent: Nederlandse Hart Registratie
theme: HEAL

https://fdp.heart-institute.nl/dataset/0cf0be10-c7ad-415e-9554-b4455c84a57f
type: Dataset
applicable legislation: oj
population coverage: collection type: Other | data categories: Not available | materials: Other | omics: Proteomics | imaging: N | sex: Not asked
access rights: RESTRICTED
creator: Dutch Cardiovascular Alliance (DCVA)
description: DCVA sample collection Outflow tract related aging with congenital heart defects: identifying causes and mechanisms of myocardial and large vessel wall adaptation, predictors for long term outcome and targets for improved treatment.
issued: 2021-10-01T00:00:00+00:00
language: en
modified: 2026-05-13T11:47:20.618328
provenance: ProvenanceStatement
publisher: Dutch Cardiovascular Alliance (DCVA)
spatial: NLD
temporal: PeriodOfTime
  end date: 2023-01-31T00:00:00+00:00
  start date: 2021-10-01T00:00:00+00:00
title: Outflow tract related aging with congenital heart defects: identifying causes and mechanisms of myocardial and large vessel wall adaptation, predictors for long term outcome and targets for improved treatment.
contact point: Kind
  fn: DCVA
  has URL: ']
keyword: Not asked
keyword: Not available
keyword: OUTREACH WP6
keyword: Other
keyword: Proteomics
qualified attribution: Attribution
  agent: Dutch Cardiovascular Alliance (DCVA)
theme: HEAL

CAPACITY-COVID
type: Dataset
applicable legislation: oj
min typical age: 18
number of unique individuals: 13800
population coverage: collection type: Cohort,Disease specific,Hospital | data categories: Medical records,National registries,Physiological/Biochemical measurements,Survey data | materials: Not available | omics: Not available | imaging: N | sex: Female,Male
access rights: RESTRICTED
creator: Dutch Cardiovascular Alliance (DCVA)
description: CAPACITY is a registry of patients with COVID-19 across Europe and has been established to answer questions on the role of cardiovascular disease in this pandemic. It is an extension of the Case Record Form (CRF) that was released by the ISARIC (International Severe Acute Respiratory and Emerging Infection Consortium) and WHO (World Health Organisation) in response to the emerging outbreak of COVID-19.The aim of CAPACITY is to collect data regarding the cardiovascular history, diagnostic information and occurrence of cardiovascular complications in COVID-19 patients. By collecting this information in a standardized manner, CAPACITY can aid in providing more insight in (1) the incidence of cardiovascular complications in patients with COVID-19, and (2) the vulnerability and clinical course of COVID-19 in patients with an underlying cardiovascular disease
issued: 2020-03-27T00:00:00+00:00
language: en
modified: 2026-05-13T11:47:00.610951
provenance: ProvenanceStatement
publisher: Dutch Cardiovascular Alliance (DCVA)
spatial: NLD
temporal: PeriodOfTime
  end date: 2020-08-24T00:00:00+00:00
  start date: 2020-03-27T00:00:00+00:00
contact point: Kind
  fn: DCVA
  has URL: ']
keyword: CAPACITY-COVID
keyword: Cohort
keyword: Disease specific
keyword: Female
keyword: Hospital
keyword: Male
keyword: Medical records
keyword: National registries
keyword: Not available
keyword: Physiological Biochemical measurements
keyword: Survey data
qualified attribution: Attribution
  agent: Dutch Cardiovascular Alliance (DCVA)
theme: HEAL

Atrial Fibrillation Fingerprinting
type: Dataset
applicable legislation: oj
max typical age: 85
min typical age: 42
population coverage: collection type: Cohort,Disease specific,Hospital,Non-Human,Sample collection | disease: Other conduction disorders | data categories: Biological samples,Imaging data,Medical records,Physiological/Biochemical measurements,Other | materials: cDNA / mRNA,Cell lines,DNA,Serum,Tissue, cryo preserved | omics: Proteomics | imaging: N | sex: Female,Male
access rights: RESTRICTED
creator: Dutch Cardiovascular Alliance (DCVA)
description: Atrial fibrillation (AF) is the most common age-related cardiac rhythm disorder accounting for about one-third of rhythm abnormalities related hospitalizations with annual costs in the European Union of 13 billion euro. Early recognition of AF is essential for prevention of disease progression from recurrent intermittent episodes to finally permanent AF. This progression is accompanied by a gradual increase in therapy failure and can in the end-stage even with extensive therapy not be treated. Persistence of AF is rooted in the presence of electropathology, which is defined as complex electrical conduction disorders caused by structural damage of atrial tissue. Therefore, early recognition of AF susceptibility in patients is of prime importance to halt electropathology and hence disease onset and progression. At present, AF can only be diagnosed with a surface electrocardiogram when a patient already suffers from AF. In addition, this rhythm registration cannot assess the degree of electropathology and thus the stage of AF which is essential for selection of the appropriate therapy. Hence, early recognition of AF and the start of effective treatment is seriously hampered. By exploiting electropathology, we are able to develop a novel diagnostic instrument to predict AF onset and early progression. We hypothesize that every patient has a unique biological and electrical signal profile that is influenced by age, gender and heart disease. This bio-electrical profile is deduced from the ratio abnormal/normal electrical signals in the atria and determination of specific biomarkers levels in tissue or blood samples related to structural damage. These outcomes are summarized in an AF Fingerprint. The primary objective of this project is to design a patient-specific invasive and non-invasive AF Fingerprint, which reveals the degree of electropathology and can be used to early recognize AF onset or progression in daily clinical practice. Hereto we utilize a bottom-up study d…
issued: 2017-01-01T00:00:00+00:00
language: en
modified: 2026-05-13T11:44:04.711357
provenance: ProvenanceStatement
publisher: Dutch Cardiovascular Alliance (DCVA)
spatial: NLD
temporal: PeriodOfTime
  end date: 2021-01-01T00:00:00+00:00
  start date: 2017-01-01T00:00:00+00:00
contact point: Kind
  fn: DCVA
  has URL: ']
keyword: AFFIP
keyword: Biological samples
keyword: Cell lines
keyword: Cohort
keyword: DNA
keyword: Disease specific
keyword: Female
keyword: Hospital
keyword: Imaging data
keyword: Male
keyword: Medical records
keyword: Non-Human
keyword: Other
keyword: Other conduction disorders
keyword: Physiological Biochemical measurements
keyword: Proteomics
keyword: Sample collection
keyword: Serum
keyword: Tissue
keyword: cDNA mRNA
keyword: cryo preserved
qualified attribution: Attribution
  agent: Dutch Cardiovascular Alliance (DCVA)
theme: HEAL

Coronary ARtery disease: Risk estimations and Interventions for prevention and EaRly detection
type: Dataset
applicable legislation: oj
min typical age: 18
population coverage: collection type: Hospital | disease: coronary artery disease | data categories: Medical records,National registries,Survey data,Other | imaging: Y | sex: Undifferentiated
access rights: RESTRICTED
creator: Dutch Cardiovascular Alliance (DCVA)
description: CARRIER proposes a big data-driven approach to detection and prevention of coronary artery disease. Models learnt from big data will help identify patients at increased risk and will drive disease management. An electronic lifestyle coach will support adherence to a personalised health management plan co-created by patients and clinicians.
issued: 2020-01-01T00:00:00+00:00
language: en
modified: 2026-05-13T11:46:09.383107
provenance: ProvenanceStatement
publisher: Dutch Cardiovascular Alliance (DCVA)
spatial: NLD
temporal: PeriodOfTime
  end date: 2025-01-01T00:00:00+00:00
  start date: 2020-01-01T00:00:00+00:00
contact point: Kind
  fn: DCVA
  has URL: ']
keyword: CARRIER
keyword: Hospital
keyword: Medical records
keyword: National registries
keyword: Other
keyword: Survey data
keyword: Undifferentiated
keyword: coronary artery disease
qualified attribution: Attribution
  agent: Dutch Cardiovascular Alliance (DCVA)
theme: HEAL

Optimal Early Recognition of persons at high risk of Aneurysmal Subarachnoid hemorrhagE
type: Dataset
applicable legislation: oj
max typical age: 70
min typical age: 27
number of unique individuals: 220
population coverage: collection type: Cohort | disease: Other cerebrovascular diseases - Cerebral aneurysm, nonruptured | data categories: Imaging data,Medical records | materials: Not available | omics: Genomics | imaging: Y | sex: Female,Male
access rights: RESTRICTED
creator: Dutch Cardiovascular Alliance (DCVA)
description: ERASE will deliver: 1. Knowledge if we should also offer screening for intracranial aneurysms (IA) to persons 1. who have a positive family history with first degree relatives with unruptured IA and 2. ≥35 yr who smoke(d) and have hypertension. 3. Genetic, clinical and anatomical risk factors that will contribute to the ability to predict persons at risk for IAs.
issued: 2016-12-01T00:00:00+00:00
language: en
modified: 2026-05-13T11:47:05.956845
provenance: ProvenanceStatement
publisher: Dutch Cardiovascular Alliance (DCVA)
spatial: NLD
temporal: PeriodOfTime
  end date: 2021-11-30T00:00:00+00:00
  start date: 2016-12-01T00:00:00+00:00
contact point: Kind
  fn: DCVA
  has URL: ']
keyword: Cohort
keyword: ERASE
keyword: Female
keyword: Genomics
keyword: Imaging data
keyword: Male
keyword: Medical records
keyword: Not available
keyword: Other cerebrovascular diseases - Cerebral aneurysm
keyword: nonruptured
qualified attribution: Attribution
  agent: Dutch Cardiovascular Alliance (DCVA)
theme: HEAL

ECG-AI
type: Dataset
applicable legislation: oj
max typical age: 85
min typical age: 18
population coverage: collection type: Population-based | data categories: Imaging data,Medical records,Physiological/Biochemical measurements,Other | materials: Not available | omics: Not available | imaging: Y | sex: Female,Male
access rights: RESTRICTED
creator: Dutch Cardiovascular Alliance (DCVA)
description: Developing AI for ECG interpretation
issued: 2018-11-01T00:00:00+00:00
language: en
modified: 2026-05-13T11:45:52.980454
provenance: ProvenanceStatement
publisher: Dutch Cardiovascular Alliance (DCVA)
spatial: NLD
temporal: PeriodOfTime
  end date: 2032-11-30T00:00:00+00:00
  start date: 2018-11-01T00:00:00+00:00
contact point: Kind
  fn: DCVA
  has URL: ']
keyword: ECG-AI
keyword: Female
keyword: Imaging data
keyword: Male
keyword: Medical records
keyword: Not available
keyword: Other
keyword: Physiological Biochemical measurements
keyword: Population-based
qualified attribution: Attribution
  agent: Dutch Cardiovascular Alliance (DCVA)
theme: HEAL

Renal connection to microvascular disease and heart failure with preserved ejection fraction: the next phase
type: Dataset
applicable legislation: oj
population coverage: collection type: Non-Human
access rights: RESTRICTED
creator: Dutch Cardiovascular Alliance (DCVA)
description: DCVA sample collection Renal connection to microvascular disease and heart failure with preserved ejection fraction: the next phase
issued: 2021-07-01T00:00:00+00:00
language: en
modified: 2026-05-13T11:46:11.408426
provenance: ProvenanceStatement
publisher: Dutch Cardiovascular Alliance (DCVA)
spatial: NLD
temporal: PeriodOfTime
  end date: 2026-07-01T00:00:00+00:00
  start date: 2021-07-01T00:00:00+00:00
contact point: Kind
  fn: DCVA
  has URL: ']
keyword: Non-Human
keyword: RECONNEXT non-clinical part
qualified attribution: Attribution
  agent: Dutch Cardiovascular Alliance (DCVA)
theme: HEAL

Perfect Fit: Targeting key risk factors for cardiovascular disease in at-risk individuals using a personalized and adaptive approach
type: Dataset
applicable legislation: oj
min typical age: 18
population coverage: collection type: Population-based | data categories: Biological samples,Medical records,National registries,Physiological/Biochemical measurements,Survey data,Other | sex: Undifferentiated
access rights: RESTRICTED
creator: Dutch Cardiovascular Alliance (DCVA)
description: Smoking and insufficient physical activity are key risk factors for cardiovascular disease. Perfect Fit uses big data science techniques to develop highly personalized and adaptive virtual coaching for individuals at risk of cardiovascular disease. This will help them to live healthily and prevent disease.
issued: 2020-01-01T00:00:00+00:00
language: en
modified: 2026-05-13T11:45:58.175544
provenance: ProvenanceStatement
publisher: Dutch Cardiovascular Alliance (DCVA)
spatial: NLD
temporal: PeriodOfTime
  end date: 2025-01-01T00:00:00+00:00
  start date: 2020-01-01T00:00:00+00:00
contact point: Kind
  fn: DCVA
  has URL: ']
keyword: Biological samples
keyword: Medical records
keyword: National registries
keyword: Other
keyword: Perfect fit
keyword: Physiological Biochemical measurements
keyword: Population-based
keyword: Survey data
keyword: Undifferentiated
qualified attribution: Attribution
  agent: Dutch Cardiovascular Alliance (DCVA)
theme: HEAL

Digoxin Evaluation in Chronic heart failure: Investigational Study In Outpatients in the Netherlands
type: Dataset
applicable legislation: oj
population coverage: collection type: Disease specific,Hospital | data categories: Medical records,Physiological/Biochemical measurements | materials: Plasma,Serum | omics: Not available | imaging: N | sex: Female,Male
access rights: RESTRICTED
creator: Dutch Cardiovascular Alliance (DCVA)
description: Investigation whether low-level, aiming for serum concentrations 0.5-0.9ng/mL, digoxin on top of standard treatment (guideline-recommended therapy), is beneficial in HF patients with reduced or mid-range ejection fractions (LVEF ≤50%); in a double-blind placebo controlled clinical trial.
issued: 2020-07-01T00:00:00+00:00
language: en
modified: 2026-05-13T11:43:42.115975
provenance: ProvenanceStatement
publisher: Dutch Cardiovascular Alliance (DCVA)
spatial: NLD
temporal: PeriodOfTime
  start date: 2020-07-01T00:00:00+00:00
contact point: Kind
  fn: DCVA
  has URL: ']
keyword: DECISION
keyword: Disease specific
keyword: Female
keyword: Hospital
keyword: Male
keyword: Medical records
keyword: Not available
keyword: Physiological Biochemical measurements
keyword: Plasma
keyword: Serum
qualified attribution: Attribution
  agent: Dutch Cardiovascular Alliance (DCVA)
theme: HEAL

BENEFIT for all: The Ecosystem for Healthy Living
type: Dataset
applicable legislation: oj
population coverage: collection type: Cohort,Disease specific,Hospital,Longitudinal | disease: Ischaemic heart diseases | data categories: Medical records,Physiological/Biochemical measurements,Survey data | materials: Not available | omics: Not available | imaging: N | sex: Female,Male
access rights: RESTRICTED
creator: Dutch Cardiovascular Alliance (DCVA)
description: BENEFIT is an ecosystem for healthy living and an integrated loyalty program that rewards patients for the time and energy spent on healthy lifestyle activities. By rewarding everyday lifestyle and adherence behaviors, the program integrates care and non-care settings and facilitates embedding the new lifestyle in everyday life.
issued: 2017-09-01T00:00:00+00:00
language: en
modified: 2026-05-13T11:46:54.271545
provenance: ProvenanceStatement
publisher: Dutch Cardiovascular Alliance (DCVA)
spatial: NLD
temporal: PeriodOfTime
  end date: 2022-09-01T00:00:00+00:00
  start date: 2017-09-01T00:00:00+00:00
contact point: Kind
  fn: DCVA
  has URL: ']
keyword: BENEFIT
keyword: Cohort
keyword: Disease specific
keyword: Female
keyword: Hospital
keyword: Ischaemic heart diseases
keyword: Longitudinal
keyword: Male
keyword: Medical records
keyword: Not available
keyword: Physiological Biochemical measurements
keyword: Survey data
qualified attribution: Attribution
  agent: Dutch Cardiovascular Alliance (DCVA)
theme: HEAL

Early detection of 'silent' myocardial ischemia and cardiac dysfunction in asymptomatic individuals with increased coronary artery calcium scores
type: Dataset
applicable legislation: oj
max typical age: 80
min typical age: 45
number of unique individuals: 1600
population coverage: collection type: Case-Control,Hospital,Image collection,Population-based | disease: Angina pectoris,Acute myocardial infarction,Subsequent myocardial infarction,Certain current complications following acute myocardial infarction,Other acute ischaemic heart diseases,Chronic ischaemic heart disease | data categories: Biological samples,Imaging data,National registries | materials: Plasma,Whole Blood | omics: Not available | imaging: Y | sex: Female,Male
access rights: RESTRICTED
creator: Dutch Cardiovascular Alliance (DCVA)
description: Population-based study investigating the diagnostic yield of stress perfusion MRI for early detection of coronary heart disease in asymptomatic individuals with increased calcium scores. In addition, cost-effectiveness of a diagnostic screening algorithm for cardiovacular disease will be studied.
issued: 2019-05-15T00:00:00+00:00
language: en
modified: 2026-05-13T11:46:30.347587
provenance: ProvenanceStatement
publisher: Dutch Cardiovascular Alliance (DCVA)
spatial: NLD
temporal: PeriodOfTime
  end date: 2025-12-31T00:00:00+00:00
  start date: 2019-05-15T00:00:00+00:00
contact point: Kind
  fn: DCVA
  has URL: ']
keyword: Acute myocardial infarction
keyword: Angina pectoris
keyword: Biological samples
keyword: Case-Control
keyword: Certain current complications following acute myocardial infarction
keyword: Chronic ischaemic heart disease
keyword: Early-Synergy
keyword: Female
keyword: Hospital
keyword: Image collection
keyword: Imaging data
keyword: Male
keyword: National registries
keyword: Not available
keyword: Other acute ischaemic heart diseases
keyword: Plasma
keyword: Population-based
keyword: Subsequent myocardial infarction
keyword: Whole Blood
qualified attribution: Attribution
  agent: Dutch Cardiovascular Alliance (DCVA)
theme: HEAL

Congenitale cardiothoracale chirurgie
type: Dataset
applicable legislation: oj
health category: Q235007
population coverage: Patiënten (kinderen en volwassenen) die een congenitale cardiochirurgische ingreep hebben ondergaan.
access rights: RESTRICTED
accrual periodicity: ANNUAL
creator: Nederlandse Hart Registratie
description: De congenitale cardiothoracale chirurgie registratie omvat alle uitgevoerde congenitale cardiochirurgie ingrepen bij kinderen en volwassenen.
issued: 2015-01-01T00:00:00+00:00
language: NLD
modified: 2026-05-13T11:44:00.098620
provenance: ProvenanceStatement
publisher: Nederlandse Hart Registratie
spatial: NLD
temporal: PeriodOfTime
  start date: 2015-01-01T00:00:00+00:00
contact point: Kind
  fn: NHR
  has URL: ']
keyword: CCTC
keyword: congenital cardiac surgery
keyword: congenital heart disease CHD
keyword: heart
keyword: open-heart surgery
keyword: quality registry
qualified attribution: Attribution
  agent: Nederlandse Hart Registratie
theme: HEAL

Cardiac complications in Patients with SARS Corona virus 2 registry
type: Dataset
applicable legislation: oj
min typical age: 18
number of unique individuals: 5000
population coverage: collection type: Cohort,Hospital,Population-based | disease: Heart disease, unspecified | data categories: Medical records,Physiological/Biochemical measurements | materials: Not available | omics: Not available | imaging: N | sex: Female,Male
access rights: RESTRICTED
creator: Dutch Cardiovascular Alliance (DCVA)
description: The aim of CAPACITY is to collect data regarding the cardiovascular history, diagnostic information and occurrence of cardiovascular complications in COVID-19 patients. By collecting this information in a standardized manner, CAPACITY can aid in providing more insight in (1) the incidence of cardiovascular complications in patients with COVID-19, and (2) the vulnerability and clinical course of COVID-19 in patients with an underlying cardiovascular disease.
issued: 2020-03-16T00:00:00+00:00
language: en
modified: 2026-05-13T11:44:55.842383
provenance: ProvenanceStatement
publisher: Dutch Cardiovascular Alliance (DCVA)
spatial: NLD
temporal: PeriodOfTime
  end date: 2020-09-30T00:00:00+00:00
  start date: 2020-03-16T00:00:00+00:00
contact point: Kind
  fn: DCVA
  has URL: ']
keyword: CAPACITY-COVID Registry
keyword: Cohort
keyword: Female
keyword: Heart disease
keyword: Hospital
keyword: Male
keyword: Medical records
keyword: Not available
keyword: Physiological Biochemical measurements
keyword: Population-based
keyword: unspecified
qualified attribution: Attribution
  agent: Dutch Cardiovascular Alliance (DCVA)
theme: HEAL

Detection Of Latent Pulmonary Hypertension In Genetically Susceptible Individuals
type: Dataset
applicable legislation: oj
max typical age: 78
min typical age: 21
population coverage: collection type: Cohort,Longitudinal,Rare disease collection,Sample collection | disease: pulmonary arterial hypertension | data categories: Biological samples,Imaging data,Medical records,Survey data | materials: Peripheral blood cells,Plasma,Serum,Urine,Whole Blood | omics: Not available | imaging: Y | sex: Female,Male
access rights: RESTRICTED
creator: Dutch Cardiovascular Alliance (DCVA)
description: longitudinal follow-up program for early detection of PAH in unaffected carriers. these carriers are compared with Idiopathic PAH patients, heritable PAH patients and healthy controls.
is referenced by: https://pubmed.ncbi.nlm.nih.gov/32409423/
issued: 2017-09-07T00:00:00+00:00
language: en
modified: 2026-05-13T11:44:02.195638
provenance: ProvenanceStatement
publisher: Dutch Cardiovascular Alliance (DCVA)
spatial: NLD
temporal: PeriodOfTime
  start date: 2017-09-07T00:00:00+00:00
contact point: Kind
  fn: DCVA
  has URL: ']
keyword: Biological samples
keyword: Cohort
keyword: DOLPHIN-GENESIS
keyword: Female
keyword: Imaging data
keyword: Longitudinal
keyword: Male
keyword: Medical records
keyword: Not available
keyword: Peripheral blood cells
keyword: Plasma
keyword: Rare disease collection
keyword: Sample collection
keyword: Serum
keyword: Survey data
keyword: Urine
keyword: Whole Blood
keyword: pulmonary arterial hypertension
qualified attribution: Attribution
  agent: Dutch Cardiovascular Alliance (DCVA)
theme: HEAL

Early detection of cardiac dysfunction in childhood cancer survivors; a LATER study
type: Dataset
applicable legislation: oj
max typical age: 65
min typical age: 16
number of unique individuals: 1800
population coverage: collection type: Cross-sectional,Disease specific,Image collection | disease: Cardiomyopathy | data categories: Biological samples,Imaging data,Medical records,Physiological/Biochemical measurements,Survey data | materials: Serum,Whole Blood | omics: Not available | imaging: Y | sex: Female,Male,Undifferentiated
access rights: RESTRICTED
creator: Dutch Cardiovascular Alliance (DCVA)
description: We collected cardiac data (history, phusica; examination, Echo, ECG, Blood) from 1550 chidlhood cancer survivors and 250 sibling.
issued: 2017-02-01T00:00:00+00:00
language: en
modified: 2026-05-13T11:44:42.690888
provenance: ProvenanceStatement
publisher: Dutch Cardiovascular Alliance (DCVA)
spatial: NLD
temporal: PeriodOfTime
  end date: 2022-03-01T00:00:00+00:00
  start date: 2017-02-01T00:00:00+00:00
contact point: Kind
  fn: DCVA
  has URL: ']
keyword: Biological samples
keyword: Cardiomyopathy
keyword: Cross-sectional
keyword: Disease specific
keyword: Female
keyword: Image collection
keyword: Imaging data
keyword: LATER CARD
keyword: Male
keyword: Medical records
keyword: Not available
keyword: Physiological Biochemical measurements
keyword: Serum
keyword: Survey data
keyword: Undifferentiated
keyword: Whole Blood
qualified attribution: Attribution
  agent: Dutch Cardiovascular Alliance (DCVA)
theme: HEAL

SUstainable PREvention of cardioMEtabolic risk through NUDGing hEalth behaviors
type: Dataset
applicable legislation: oj
population coverage: collection type: Other | disease: Type 2 diabetes mellitus,Cardiovascular disease, unspecified | data categories: Physiological/Biochemical measurements,Survey data,Other | materials: Not available | omics: Not available | imaging: N | sex: Female,Male
access rights: RESTRICTED
creator: Dutch Cardiovascular Alliance (DCVA)
description: Een gezonde leefstijl - een gezond voedingspatroon en voldoende bewegen - draagt in belangrijke mate bij aan de preventie van chronische ziekten. Mensen met lage sociaal-economische status (SES) hebben vaak een ongezondere leefstijl dan mensen met een hogere SES. Echter, interventies gericht op het stimuleren van een gezonde leefstijl bereiken juist deze lage SES doelgroep slecht en kunnen sociale ongelijkheid vergroten. Een mogelijke verklaring hiervoor is dat interventies zich traditioneel veelal richten op individuele determinanten van gedrag zoals kennis, attitudes en intenties. Bovendien zijn deze interventies veelal niet effectief, mede doordat er geen rekening gehouden wordt met de - sociale, fysieke en politieke - context waarin leefstijlkeuzes gemaakt worden: ongezond gedrag kan worden gezien als een automatische reactie op de 'obesogene' omgeving. Veranderingen in en van de omgeving waarin mensen leven kunnen in belangrijke mate helpen om een gezonde leefstijl te bevorderen en alle doelgroepen te bereiken. Door veranderingen in de omgeving moet gezorgd worden dat de gezonde keuze de makkelijke keuze, de voor de hand liggende keuze of zelfs de enige keuze wordt, juist ook voor de moeilijke bereikbare en veranderbare doelgroepen zoals mensen met een lagere opleiding. Echter, of omgevingsinterventies ook op langere termijn effectief zijn voor het verbeteren van risicofactoren voor hart- en vaatziekten is niet bekend en moet onderzocht worden. In SUPREME NUDGE wordt een geïntegreerde interventie in supermarkten ontwikkeld en onderzocht, waarin de 'supermarktomgeving' zo wordt ingericht dat de gezonde voedselkeuze makkelijker en vanzelfsprekender wordt. De supermarkt is een belangrijke omgeving waarin (leefstijl)keuzes worden gemaakt, en waar het verleiden tot gezondere voedingskeuzes via productplaatsing, prijsverandering en berichten directe en langdurende effecten kan hebben. Dit wordt gecombineerd met een m-health promotion interventie waarmee mensen direct…
issued: 2017-07-01T00:00:00+00:00
language: en
modified: 2026-05-13T11:43:35.971724
provenance: ProvenanceStatement
publisher: Dutch Cardiovascular Alliance (DCVA)
spatial: NLD
temporal: PeriodOfTime
  end date: 2022-06-30T00:00:00+00:00
  start date: 2017-07-01T00:00:00+00:00
contact point: Kind
  fn: DCVA
  has URL: ']
keyword: Cardiovascular disease
keyword: Female
keyword: Male
keyword: Not available
keyword: Other
keyword: Physiological Biochemical measurements
keyword: SUPREME NUDGE
keyword: Survey data
keyword: Type 2 diabetes mellitus
keyword: unspecified
qualified attribution: Attribution
  agent: Dutch Cardiovascular Alliance (DCVA)
theme: HEAL

Early detection of disease in cardiomyopathy mutation carriers
type: Dataset
applicable legislation: oj
min typical age: 18
number of unique individuals: 926
population coverage: collection type: Rare disease collection | disease: Dilated cardiomyopathy | data categories: Biological samples,Imaging data,Medical records,National registries,Physiological/Biochemical measurements | materials: DNA,Plasma,Serum,Whole Blood | omics: Genomics | imaging: Y | sex: Female,Male
access rights: RESTRICTED
creator: Dutch Cardiovascular Alliance (DCVA)
description: A campaign to inform the general public and online tools to evaluate indications for cardiogenetic referral will be launched. The yield of novel methods to reach out to family members will be investigated and if successful, implemented into routine cascade testing. Advanced non-invasive imaging and non-invasive electrophysiological measurements will be performed in mutation carriers and asymptomatic family members to detect early signs of cardiac disease, with special attention to sex differences. As exemplar for all inherited cardiomyopathies, early detection at individual and cellular level will focus on patients and their family members with PLN or PKP2 gene founder mutations. Early detection facilitates risk stratification and timely therapeutic interventions, thereby reducing mortality and morbidity. A national infrastructure will be developed to facilitate biomarker discovery and follow-up research. Extensive genetic and phenotypic (including imaging) data will be stored and integrated into a central data warehouse to facilitate data sharing and guarantee long-term sustainability of the registries. As such, e-DETECT will help in the prevention of cardiac dysfunction and SCD among young, apparently healthy individuals. By 2030, the consortium aims to increase the uptake of cascade testing in family members by 50% and thereby detect up to 25% more patients at true risk. This increased uptake will enable regular follow up and timely treatment, thereby reducing morbidity and mortality.
issued: 2017-01-01T00:00:00+00:00
language: en
modified: 2026-05-13T11:46:57.243936
provenance: ProvenanceStatement
publisher: Dutch Cardiovascular Alliance (DCVA)
spatial: NLD
temporal: PeriodOfTime
  end date: 2022-01-01T00:00:00+00:00
  start date: 2017-01-01T00:00:00+00:00
contact point: Kind
  fn: DCVA
  has URL: ']
keyword: Biological samples
keyword: DNA
keyword: Dilated cardiomyopathy
keyword: Female
keyword: Genomics
keyword: Imaging data
keyword: Male
keyword: Medical records
keyword: National registries
keyword: Physiological Biochemical measurements
keyword: Plasma
keyword: Rare disease collection
keyword: Serum
keyword: Whole Blood
keyword: eDETECT
qualified attribution: Attribution
  agent: Dutch Cardiovascular Alliance (DCVA)
theme: HEAL

https://fdp.heart-institute.nl/dataset/3c43b9b0-bf81-42b8-9c99-2a052eef606e
type: Dataset
applicable legislation: oj
max typical age: 75
min typical age: 18
population coverage: collection type: Cohort,Disease specific,Image collection | data categories: Imaging data,Medical records | materials: Not available | omics: Not available | imaging: Y | sex: Female,Male,Undifferentiated
access rights: RESTRICTED
creator: Dutch Cardiovascular Alliance (DCVA)
description: The CAS study is a clinical observational study investigating the effects of ConAoS on the left ventricular function and the prevalence, pattern and expanse of LVH, myocardial stiffness and myocardial fibrosis. Moreover, we will assess the prognostic capacity of the presence of these pathological processes, correlating our findings at baseline to clinical outcome by assessing the occurrence of cardiovascular events and all-cause mortality during 3-year clinical follow-up. We will unravel biomarker and imaging predictors for myocardial dysfunction (systolic and diastolic) with specific attention for male-female differences
issued: 2021-01-01T00:00:00+00:00
language: en
modified: 2026-05-13T11:46:21.880296
provenance: ProvenanceStatement
publisher: Dutch Cardiovascular Alliance (DCVA)
spatial: NLD
temporal: PeriodOfTime
  end date: 2022-12-31T00:00:00+00:00
  start date: 2021-01-01T00:00:00+00:00
title: Outflow tract related aging with congenital heart defects: identifying causes and mechanisms of myocardial and large vessel wall adaptation, predictors for long term outcome and targets for improved treatment.
contact point: Kind
  fn: DCVA
  has URL: ']
keyword: Cohort
keyword: Disease specific
keyword: Female
keyword: Image collection
keyword: Imaging data
keyword: Male
keyword: Medical records
keyword: Not available
keyword: OUTREACH
keyword: Undifferentiated
qualified attribution: Attribution
  agent: Dutch Cardiovascular Alliance (DCVA)
theme: HEAL

Hartfalen registratie
type: Dataset
applicable legislation: oj
health category: Q10379
population coverage: Volwassenen van 18 jaar of ouder die een eerste hartfalen diagnose hebben gekregen.
access rights: RESTRICTED
accrual periodicity: ANNUAL
creator: Nederlandse Hart Registratie
description: De Hartfalen registratie omvat patiënten met hartfalen die voldoen aan de richtlijnen en definitie ESC 2021 en 2023 focused update. De inclusie betreft in ieder geval de Novo HF patiënten met HFrEF, die primair voor hun hartfalen op de poli komen (+/- klinische opname vooraf) voor instellen van hun diagnose en behandeling van hartfalen. Voor de Hartfalen-registratie worden de patiënten tot 1 jaar na hun diagnose opgevolgd tenzij de patiënt eerder teruggaat naar de eerstelijn, overlijdt of wordt doorverwezen.
issued: 2018-01-01T00:00:00+00:00
language: NLD
modified: 2026-05-13T11:46:05.650420
provenance: ProvenanceStatement
publisher: Nederlandse Hart Registratie
spatial: NLD
temporal: PeriodOfTime
  start date: 2018-01-01T00:00:00+00:00
contact point: Kind
  fn: NHR
  has URL: ']
keyword: CHF
keyword: HFmrEF
keyword: HFpEF
keyword: HFrEF
keyword: heart
keyword: heart failure
keyword: left ventricular dysfunction
keyword: quality registry
qualified attribution: Attribution
  agent: Nederlandse Hart Registratie
theme: HEAL

Improved Prognosis of Vascular cognitive impairment using automatic quantitative imaging biomarker extraction and disease modeling
type: Dataset
applicable legislation: oj
population coverage: collection type: Other | disease: Other specified degenerative diseases of nervous system | data categories: Imaging data | materials: Not available | omics: Not available | imaging: Y | sex: Female,Male
access rights: RESTRICTED
creator: Dutch Cardiovascular Alliance (DCVA)
description: To optimally use brain imaging data in vascular cognitive impairment (VCI), the ImProVas project (i) develops and validates methods for automatic quantification of microbleeds and lacunar infarcts and (ii) develops and validates prediction methods utilizing these biomarkers. The project extends existing cohorts with novel image-derived biomarkers (HBC: https://www.ncbi.nlm.nih.gov/pubmed/29017156; TRACE-VCI: https://www.ncbi.nlm.nih.gov/pubmed/28428166).
issued: 2018-11-15T00:00:00+00:00
language: en
modified: 2026-05-13T11:46:44.066750
provenance: ProvenanceStatement
publisher: Dutch Cardiovascular Alliance (DCVA)
spatial: NLD
temporal: PeriodOfTime
  end date: 2021-11-15T00:00:00+00:00
  start date: 2018-11-15T00:00:00+00:00
contact point: Kind
  fn: DCVA
  has URL: ']
keyword: Female
keyword: ImProVas
keyword: Imaging data
keyword: Male
keyword: Not available
keyword: Other
keyword: Other specified degenerative diseases of nervous system
qualified attribution: Attribution
  agent: Dutch Cardiovascular Alliance (DCVA)
theme: HEAL

ANEURYSM@RISK: automatic intracranial aneurysm quantification, 4D flow MRI and feature learning modelling to optimize intracranial aneurysm rupture prediction.
type: Dataset
applicable legislation: oj
max typical age: 80
min typical age: 19
number of unique individuals: 200
population coverage: collection type: Cohort,Disease specific,Image collection | disease: Other cerebrovascular diseases - Cerebral aneurysm, nonruptured | data categories: Imaging data | materials: Not available | omics: Other | imaging: Y | sex: Female,Male
access rights: RESTRICTED
creator: Dutch Cardiovascular Alliance (DCVA)
description: We aim to improve rupture risk prediction by technical innovations 1) enabling automatic assessment of the UIA shape (including size), 2) determining the effect of the bloodflow on the UIA, and 3) by using machine learning methods (feature learning) to make predictions for rupture based on automatically learned aneurysm characteristics.
issued: 2018-06-01T00:00:00+00:00
language: en
modified: 2026-05-13T11:47:24.414439
provenance: ProvenanceStatement
publisher: Dutch Cardiovascular Alliance (DCVA)
spatial: NLD
temporal: PeriodOfTime
  end date: 2021-06-01T00:00:00+00:00
  start date: 2018-06-01T00:00:00+00:00
contact point: Kind
  fn: DCVA
  has URL: ']
keyword: Aneurysm risk
keyword: Cohort
keyword: Disease specific
keyword: Female
keyword: Image collection
keyword: Imaging data
keyword: Male
keyword: Not available
keyword: Other
keyword: Other cerebrovascular diseases - Cerebral aneurysm
keyword: nonruptured
qualified attribution: Attribution
  agent: Dutch Cardiovascular Alliance (DCVA)
theme: HEAL

Deep neural networks for ECG interpretation and home cardiac monitoring
type: Dataset
applicable legislation: oj
max typical age: 85
min typical age: 18
population coverage: collection type: Hospital,Longitudinal,Population-based,Rare disease collection | data categories: Medical records,Physiological/Biochemical measurements | materials: Not available | omics: Genomics | imaging: Y | sex: Female,Male
access rights: RESTRICTED
creator: Dutch Cardiovascular Alliance (DCVA)
description: Development of deep neural networks for automated analysis of electrocardiograms (ECGs) and of a medical device to obtain a multi-lead device at home. Both innovations will be integrated in this project to improve the value of the ECG both at home and in the hospital.
issued: 2020-05-01T00:00:00+00:00
language: en
modified: 2026-05-13T11:45:02.402881
provenance: ProvenanceStatement
publisher: Dutch Cardiovascular Alliance (DCVA)
spatial: NLD
temporal: PeriodOfTime
  end date: 2024-05-01T00:00:00+00:00
  start date: 2020-05-01T00:00:00+00:00
contact point: Kind
  fn: DCVA
  has URL: ']
keyword: ECGnet
keyword: Female
keyword: Genomics
keyword: Hospital
keyword: Longitudinal
keyword: Male
keyword: Medical records
keyword: Not available
keyword: Physiological Biochemical measurements
keyword: Population-based
keyword: Rare disease collection
qualified attribution: Attribution
  agent: Dutch Cardiovascular Alliance (DCVA)
theme: HEAL

CVON ARGUS
type: Dataset
applicable legislation: oj
max typical age: 65
min typical age: 45
number of unique individuals: 400
population coverage: collection type: Cohort,Sample collection | disease: Mitral valve disease, unspecified | data categories: Biological samples,Imaging data,Physiological/Biochemical measurements | materials: DNA,Peripheral blood cells,Plasma,Serum,Whole Blood | omics: Not available | imaging: Y | sex: Female,Male
access rights: RESTRICTED
creator: Dutch Cardiovascular Alliance (DCVA)
description: CCTA and adenosine CMR imaging of women and men with chest pain symptoms
issued: 2017-12-31T00:00:00+00:00
language: en
modified: 2026-05-13T11:45:10.880490
provenance: ProvenanceStatement
publisher: Dutch Cardiovascular Alliance (DCVA)
spatial: NLD
temporal: PeriodOfTime
  end date: 2020-12-31T00:00:00+00:00
  start date: 2017-12-31T00:00:00+00:00
contact point: Kind
  fn: DCVA
  has URL: ']
keyword: ARGUS
keyword: Biological samples
keyword: Cohort
keyword: DNA
keyword: Female
keyword: Imaging data
keyword: Male
keyword: Mitral valve disease
keyword: Not available
keyword: Peripheral blood cells
keyword: Physiological Biochemical measurements
keyword: Plasma
keyword: Sample collection
keyword: Serum
keyword: Whole Blood
keyword: unspecified
qualified attribution: Attribution
  agent: Dutch Cardiovascular Alliance (DCVA)
theme: HEAL

The effect of testosterone on platelet activation and inflammation intransgender men
type: Dataset
applicable legislation: oj
max typical age: 28
min typical age: 19
number of unique individuals: 35
population coverage: collection type: Cohort | data categories: Physiological/Biochemical measurements | materials: Not available | omics: Not available | imaging: N | sex: Female,Male
access rights: RESTRICTED
creator: Dutch Cardiovascular Alliance (DCVA)
description: In the TRANS study, the effect of hormone use on platelets and inflammation markers is being investigated.
is referenced by: j.endmts.2024.100201
is referenced by: https://doi.org/10.1080/09537104.2025.2567294
issued: 2019-03-01T00:00:00+00:00
language: en
modified: 2026-05-13T11:44:28.852516
provenance: ProvenanceStatement
publisher: Dutch Cardiovascular Alliance (DCVA)
spatial: NLD
temporal: PeriodOfTime
  end date: 2021-02-01T00:00:00+00:00
  start date: 2019-03-01T00:00:00+00:00
contact point: Kind
  fn: DCVA
  has URL: ']
keyword: Cohort
keyword: Female
keyword: Male
keyword: Not available
keyword: Physiological Biochemical measurements
keyword: TRANS
qualified attribution: Attribution
  agent: Dutch Cardiovascular Alliance (DCVA)
theme: HEAL

THI registratie
type: Dataset
applicable legislation: oj
health category: Q10379
population coverage: Patiënten (kinderen en volwassenen) die een transcatheter hartklepinterventie hebben ondergaan.
access rights: RESTRICTED
accrual periodicity: ANNUAL
creator: Nederlandse Hart Registratie
description: De Transcatheter Hartklepinterventie (THI) registratie omvat de volgende interventies: • transcatheter aortaklepimplantaties (TAVI) • transcatheter-mitralisklepingrepen • transcatheter-tricuspidalisklepingrepen • plaatsing van plugs ten behoeve van paravalvulaire lekkage (PVL)-sluiting • uitvoeren Percutaneous Aortic Balloon Valvuloplasty (PABV) dilatatie Hier geldt dat elke poging tot een ingreep wordt geïncludeerd vanaf het moment dat de patiënt is aangeprikt en/of een huidincisie heeft plaatsgevonden.
issued: 2013-01-01T00:00:00+00:00
language: NLD
modified: 2026-05-13T11:44:40.520444
provenance: ProvenanceStatement
publisher: Nederlandse Hart Registratie
spatial: NLD
temporal: PeriodOfTime
  start date: 2013-01-01T00:00:00+00:00
contact point: Kind
  fn: NHR
  has URL: ']
keyword: Percutaneous valve replacement
keyword: TAVI
keyword: TMVR
keyword: heart
keyword: quality registry
qualified attribution: Attribution
  agent: Nederlandse Hart Registratie
theme: HEAL

Automatic CTA Image Analysis to Support Treatment Selection in Acute Stroke
type: Dataset
applicable legislation: oj
population coverage: collection type: Other | disease: Cerebral infarction, unspecified | data categories: Imaging data | materials: Not available | omics: Not available | imaging: Y | sex: Not available
access rights: RESTRICTED
creator: Dutch Cardiovascular Alliance (DCVA)
description: Proper treatment selection in the acute phase of ischemic stroke can considerably improve patient outcome, as shown by recent studies. In the setting of acute stroke, treatment selection can be optimized using important information based on CTA imaging data. Currently this data is only assessed qualitatively, hence large opportunity for improving the use of CTA imaging data exists. Advanced decision support models that include accurate and objective quantification of CTA imaging biomarkers have the potential to greatly improve on current clinical practice. The ACCURATE project aims to develop and validate methods for the automated analysis of CTA data acquired in acute stroke phase. Additionally, the added value of such analyses for treatment selection support in the acute stroke stage will be determined within the scope of this project.
issued: 2019-12-01T00:00:00+00:00
language: en
modified: 2026-05-13T11:44:37.429699
provenance: ProvenanceStatement
publisher: Dutch Cardiovascular Alliance (DCVA)
spatial: NLD
temporal: PeriodOfTime
  end date: 2024-12-01T00:00:00+00:00
  start date: 2019-12-01T00:00:00+00:00
contact point: Kind
  fn: DCVA
  has URL: ']
keyword: Accurate
keyword: Cerebral infarction
keyword: Imaging data
keyword: Not available
keyword: Other
keyword: unspecified
qualified attribution: Attribution
  agent: Dutch Cardiovascular Alliance (DCVA)
theme: HEAL

DETERMINANTS OF SUSCEPTIBILITY IN INHERITED CARDIOMYOPATHY: TOWARDS NOVEL THERAPEUTIC APPROACHES
type: Dataset
applicable legislation: oj
max typical age: 75
min typical age: 1
population coverage: collection type: Cohort,Disease specific,Image collection,Longitudinal,Sample collection | disease: Cardiomyopathy - Other cardiomyopathies | data categories: Biological samples,Imaging data,Medical records,Physiological/Biochemical measurements,Survey data | materials: cDNA / mRNA,DNA,Plasma,RNA,Serum,Tissue, cryo preserved,Tissue, paraffin preserved,Whole Blood | omics: Genomics,Metabolomics,Proteomics,Transcriptomics | imaging: Y | sex: Female,Male
access rights: RESTRICTED
creator: Dutch Cardiovascular Alliance (DCVA)
description: Inherited cardiomyopathies (CM) are clinically heterogeneous: age of onset and disease-severity differ greatly between patients with the exact same gene mutation. The mechanisms that underlie the variation in disease susceptibility are unknown. Pilot data of DOSIS suggest an important role for secondary disease-modifiers such as additional (epi)genetic variations, environmental disease triggers, and an age-related decline in protein quality control (PQC). The PQC system prevents onset of CM by suppressing the accumulation of toxic proteins in cardiomyocytes. Moreover, CM severity is attenuated by the stimulation of protein degradation pathways. Thus, a healthy PQC system keeps mutant expression below the toxic dose. In addition, mutation location in a gene may determine disease susceptibility due to specific mutation-induced changes in protein structure, which alter PQC recognition, and affect incorporation into the sarcomere. Hypothesis: the clinical variability in CM is determined by (1) interplay between (epi)genetic and ageing-induced environmental factors (burden); (2) status of the PQC system (coping mechanisms); (3) mutation location. Aims: 1. Identify (epi)genetic modifiers influencing the CM phenotype in individuals carrying a sarcomeric mutation. 2. Elucidate derailment of the PQC system as determinant of cellular toxicity in CM. 3. Establish the toxic effect of mutants with respect to protein dose and mutation location. 4. Obtain proof of concept for age-dependent secondary disease-modifiers as key players in protein toxicity of CM mutations and test novel pharmacological interventions. DOSIS is directed at understanding the path a mutation needs to travel to become toxic, and at testing novel therapies in experimental model systems.
issued: 2015-12-01T00:00:00+00:00
language: en
modified: 2026-05-13T11:45:19.683860
provenance: ProvenanceStatement
publisher: Dutch Cardiovascular Alliance (DCVA)
spatial: NLD
temporal: PeriodOfTime
  end date: 2020-11-30T00:00:00+00:00
  start date: 2015-12-01T00:00:00+00:00
contact point: Kind
  fn: DCVA
  has URL: ']
keyword: Biological samples
keyword: Cardiomyopathy - Other cardiomyopathies
keyword: Cohort
keyword: DNA
keyword: DOSIS
keyword: Disease specific
keyword: Female
keyword: Genomics
keyword: Image collection
keyword: Imaging data
keyword: Longitudinal
keyword: Male
keyword: Medical records
keyword: Metabolomics
keyword: Physiological Biochemical measurements
keyword: Plasma
keyword: Proteomics
keyword: RNA
keyword: Sample collection
keyword: Serum
keyword: Survey data
keyword: Tissue
keyword: Transcriptomics
keyword: Whole Blood
keyword: cDNA mRNA
keyword: cryo preserved
keyword: paraffin preserved
qualified attribution: Attribution
  agent: Dutch Cardiovascular Alliance (DCVA)
theme: HEAL

Endocarditis registratie
type: Dataset
applicable legislation: oj
health category: Q10379
population coverage: Volwassenen van 18 jaar of ouder die een endocarditis diagnose hebben gekregen.
access rights: RESTRICTED
accrual periodicity: ANNUAL
creator: Nederlandse Hart Registratie
description: De Endocarditis registratie omvat elke patiënt die binnen het endocarditis team wordt besproken, waarbij de diagnose ‘possible’ of ‘definite’ infectieuze endocarditis (IE) wordt gesteld. Hierbij geldt dat elke nieuwe ziekte-episode van een patiënt wordt aangeleverd. Onder IE wordt verstaan: een microbiële ontsteking van het intracardiale endotheel en/of lichaamsvreemd implantaat (zoals een pacemaker of kunstklep) waarbij voor diagnose de modified Duke criteria en/of European Society of Cardiology (ESC) endocarditis criteria worden gebruikt.
issued: 2023-01-01T00:00:00+00:00
language: NLD
modified: 2026-05-13T11:47:09.317892
provenance: ProvenanceStatement
publisher: Nederlandse Hart Registratie
spatial: NLD
temporal: PeriodOfTime
  start date: 2023-01-01T00:00:00+00:00
contact point: Kind
  fn: NHR
  has URL: ']
keyword: Prosthetic valve endocarditis
keyword: antibiotic therapy
keyword: bacterial endocarditis
keyword: endocarditis
keyword: heart failure
keyword: native valve endocarditis
keyword: quality registry
qualified attribution: Attribution
  agent: Nederlandse Hart Registratie
theme: HEAL

Low Dose Colchicine for Secondary Prevention of CV disease
type: Dataset
applicable legislation: oj
max typical age: 90
min typical age: 45
population coverage: collection type: Other | disease: Chronic ischaemic heart disease | data categories: Biological samples,Imaging data | materials: Peripheral blood cells,Plasma | omics: Proteomics | imaging: Y | sex: Not available
access rights: RESTRICTED
creator: Dutch Cardiovascular Alliance (DCVA)
description: see below
issued: 2014-04-01T00:00:00+00:00
language: en
modified: 2026-05-13T11:44:07.150915
provenance: ProvenanceStatement
publisher: Dutch Cardiovascular Alliance (DCVA)
spatial: NLD
temporal: PeriodOfTime
  end date: 2020-05-01T00:00:00+00:00
  start date: 2014-04-01T00:00:00+00:00
contact point: Kind
  fn: DCVA
  has URL: ']
keyword: Biological samples
keyword: Chronic ischaemic heart disease
keyword: Imaging data
keyword: LoDoCo2
keyword: Not available
keyword: Other
keyword: Peripheral blood cells
keyword: Plasma
keyword: Proteomics
qualified attribution: Attribution
  agent: Dutch Cardiovascular Alliance (DCVA)
theme: HEAL

QRS vectors in Solving the Inverse Problem of Electrocardiography
type: Dataset
applicable legislation: oj
max typical age: 76
min typical age: 18
population coverage: collection type: Disease specific,Image collection | disease: Cardiomyopathy - Endocardial fibroelastosis | data categories: Genealogical records,Imaging data,Other | materials: Not available | omics: Not available | imaging: Y | sex: Female,Male
access rights: RESTRICTED
creator: Dutch Cardiovascular Alliance (DCVA)
description: Electrocardiographic imaging in patients to identify early signs of disease in arrhytmogenic cardiomyopathy. Therefore, clinical MRI/CT, body surface mapping (64-electrode ECG) and 3D imaging of the electrode positions is carried out.
issued: 2018-02-01T00:00:00+00:00
language: en
modified: 2026-05-13T11:43:52.134510
provenance: ProvenanceStatement
publisher: Dutch Cardiovascular Alliance (DCVA)
spatial: NLD
temporal: PeriodOfTime
  end date: 2022-02-01T00:00:00+00:00
  start date: 2018-02-01T00:00:00+00:00
contact point: Kind
  fn: DCVA
  has URL: ']
keyword: Cardiomyopathy - Endocardial fibroelastosis
keyword: Disease specific
keyword: Female
keyword: Genealogical records
keyword: Image collection
keyword: Imaging data
keyword: Male
keyword: Not available
keyword: Other
keyword: QRS-Vision
qualified attribution: Attribution
  agent: Dutch Cardiovascular Alliance (DCVA)
theme: HEAL

GENIUS II
type: Dataset
applicable legislation: oj
max typical age: 75
min typical age: 50
number of unique individuals: 40
population coverage: collection type: Hospital,Non-Human | disease: Atherosclerosis | data categories: Biological samples,Imaging data | materials: cDNA / mRNA,Peripheral blood cells,Plasma,RNA,Serum | omics: Genomics,Transcriptomics | imaging: N | sex: Female,Male
access rights: RESTRICTED
creator: Dutch Cardiovascular Alliance (DCVA)
description: We have from the atheroexpress biobank (UMCU) cell isolates from atherectomy samples and blood cells
issued: 2017-12-01T00:00:00+00:00
language: en
modified: 2026-05-13T11:44:52.348562
provenance: ProvenanceStatement
publisher: Dutch Cardiovascular Alliance (DCVA)
spatial: NLD
temporal: PeriodOfTime
  end date: 2022-11-30T00:00:00+00:00
  start date: 2017-12-01T00:00:00+00:00
contact point: Kind
  fn: DCVA
  has URL: ']
keyword: Atherosclerosis
keyword: Biological samples
keyword: Female
keyword: GENIUS II
keyword: Genomics
keyword: Hospital
keyword: Imaging data
keyword: Male
keyword: Non-Human
keyword: Peripheral blood cells
keyword: Plasma
keyword: RNA
keyword: Serum
keyword: Transcriptomics
keyword: cDNA mRNA
qualified attribution: Attribution
  agent: Dutch Cardiovascular Alliance (DCVA)
theme: HEAL

The efficacy of aspirin to inhibit platelet aggregation in patients hospitalised with a severe infection: a multicentre, open‑label, randomised controlled trial
type: Dataset
applicable legislation: oj
max typical age: 93
min typical age: 23
number of unique individuals: 54
population coverage: collection type: Hospital,Longitudinal,Sample collection,Other | disease: Pneumonia due to staphylococcus aureus | data categories: Physiological/Biochemical measurements | materials: Not available | omics: Not available | imaging: N | sex: Female,Male
access rights: RESTRICTED
creator: Dutch Cardiovascular Alliance (DCVA)
description: We investigated whether hyperaggregation occurs during infection, and whether aspirin inhibits this. Patients hospitalised due to acute infection were randomised to receive 10 days of aspirin treatment or no intervention. Our outcome measures were PFA-Closure Time, serum thromboxane and plasma thromboxane.
is referenced by: s10238-023-01101-5
is referenced by: https://pubmed.ncbi.nlm.nih.gov/37294478/
issued: 2018-01-11T00:00:00+00:00
language: en
modified: 2026-05-13T11:46:25.748138
provenance: ProvenanceStatement
publisher: Dutch Cardiovascular Alliance (DCVA)
spatial: NLD
temporal: PeriodOfTime
  end date: 2020-12-10T00:00:00+00:00
  start date: 2018-01-11T00:00:00+00:00
contact point: Kind
  fn: DCVA
  has URL: ']
keyword: ASPIRIN
keyword: Female
keyword: Hospital
keyword: Longitudinal
keyword: Male
keyword: Not available
keyword: Other
keyword: Physiological Biochemical measurements
keyword: Pneumonia due to staphylococcus aureus
keyword: Sample collection
qualified attribution: Attribution
  agent: Dutch Cardiovascular Alliance (DCVA)
theme: HEAL

Outflow tract related aging with congenital heart disease. Workpackage Tetraogy of fallot High Intensity Interval Training
type: Dataset
applicable legislation: oj
max typical age: 43
min typical age: 12
number of unique individuals: 30
population coverage: collection type: Case-Control,Disease specific,Longitudinal,Population-based | data categories: Imaging data,Medical records,Physiological/Biochemical measurements,Survey data | materials: Serum | omics: Not available | imaging: Y | sex: Female,Male
access rights: RESTRICTED
creator: Dutch Cardiovascular Alliance (DCVA)
description: Rationale: Tetralogy of Fallot is the most common type of cyanotic congenital heart disease. The main problems of this patient population are heart failure related to chronic pulmonary regurgitation, arrhythmias and sudden cardiac death. A major gap in our knowledge is how coupling between the RV and pulmonary artery affects outcomes. It has been shown that aortic pulse wave velocity can be improved by exercise training in Tetralogy of Fallot. Objective: Primary Objective: To examine the effect of an online based exercise training protocol on ventriculo-arterial coupling , as assessed by pulse wave velocity in the aorta and pulmonary artery in patients operated for Tetralogy of Fallot. Study design: cross-over interventional study. All children and young adults will be randomized in 2 groups. One group will start with care/exercise as usual, the other group will start with an online exercise training. After 12 weeks the groups will change from protocol. Before start of measurements, after 12 weeks and group 2 after 24 weeks, all participants will undergo a number of tests, including echocardiogram, cardiopulmonary exercise test, and cardiac magnetic resonance imaging. Study population: 12-30 years of age, after surgical repair of tetralogy of Fallot (TOF), being followed at one of the 2 locations of the Academic Center for Congenital Heart disease (ACAHA). Intervention: 12 weeks of online based interval training 3 times a week. Main study parameters/endpoints: Decrease in pulse wave velocity in the aorta and pulmonary artery measured by MRI.
issued: 2020-01-01T00:00:00+00:00
language: en
modified: 2026-05-13T11:47:36.201864
provenance: ProvenanceStatement
publisher: Dutch Cardiovascular Alliance (DCVA)
spatial: NLD
temporal: PeriodOfTime
  end date: 2025-12-31T00:00:00+00:00
  start date: 2020-01-01T00:00:00+00:00
contact point: Kind
  fn: DCVA
  has URL: ']
keyword: Case-Control
keyword: Disease specific
keyword: Female
keyword: Imaging data
keyword: Longitudinal
keyword: Male
keyword: Medical records
keyword: Not available
keyword: OUTREACH ToFHIIT study
keyword: Physiological Biochemical measurements
keyword: Population-based
keyword: Serum
keyword: Survey data
qualified attribution: Attribution
  agent: Dutch Cardiovascular Alliance (DCVA)
theme: HEAL

DEFENCE: Determination and Evaluation of the Frequency and Effects of myocardial damage iNpatients with a SARS-CoV-2 infEction
type: Dataset
applicable legislation: oj
max typical age: 70
min typical age: 18
number of unique individuals: 500
population coverage: collection type: Cohort,Disease specific,Hospital | data categories: Imaging data,Medical records,Physiological/Biochemical measurements,Survey data | materials: Not available | omics: Not available | imaging: Y | sex: Female,Male
access rights: RESTRICTED
creator: Dutch Cardiovascular Alliance (DCVA)
description: With our project we strive to maximally utilize existing data and registries. However, new data needs to be collected, primarily due to three reasons: (1) routine clinical care so far has lacked standardized diagnostic tests for the detection of myocardial damageafter COVID-19; (2) the established cohorts have no funding for repeated measurements/follow-up to assess the (ir)reversibility of myocardial damage and (3) no patient reported outcome data are available that could function as a potential alert of ongoing myocardial problems following COVID-19.
issued: 2021-10-01T00:00:00+00:00
language: en
modified: 2026-05-13T11:47:04.144529
provenance: ProvenanceStatement
publisher: Dutch Cardiovascular Alliance (DCVA)
spatial: NLD
temporal: PeriodOfTime
  start date: 2021-10-01T00:00:00+00:00
contact point: Kind
  fn: DCVA
  has URL: ']
keyword: Cohort
keyword: DEFENCE
keyword: Disease specific
keyword: Female
keyword: Hospital
keyword: Imaging data
keyword: Male
keyword: Medical records
keyword: Not available
keyword: Physiological Biochemical measurements
keyword: Survey data
qualified attribution: Attribution
  agent: Dutch Cardiovascular Alliance (DCVA)
theme: HEAL

ArmCoach4Stroke
type: Dataset
applicable legislation: oj
max typical age: 75
min typical age: 35
population coverage: collection type: Cross-sectional,Disease specific,Longitudinal | data categories: Survey data,Other | materials: Not available | omics: Not available | imaging: N | sex: Female,Male
access rights: RESTRICTED
creator: Dutch Cardiovascular Alliance (DCVA)
description: The multidisciplinary ArmCoach4Stroke project aims to develop and evaluate a new and interactive therapy aid based on movement sensors to stimulate and optimize the daily use and exercise of the affected arm in the home environment by objective, personalized feedback to the patient and his/her therapist.The ArmCoach4Stroke will be developed in co-creation with patients and therapists and other (end)users, with focus on optimal implementation in health care.
issued: 2020-07-01T00:00:00+00:00
language: en
modified: 2026-05-13T11:46:19.030911
provenance: ProvenanceStatement
publisher: Dutch Cardiovascular Alliance (DCVA)
spatial: NLD
temporal: PeriodOfTime
  end date: 2024-07-01T00:00:00+00:00
  start date: 2020-07-01T00:00:00+00:00
contact point: Kind
  fn: DCVA
  has URL: ']
keyword: ArmCoach4Stroke
keyword: Cross-sectional
keyword: Disease specific
keyword: Female
keyword: Longitudinal
keyword: Male
keyword: Not available
keyword: Other
keyword: Survey data
qualified attribution: Attribution
  agent: Dutch Cardiovascular Alliance (DCVA)
theme: HEAL

Technology Of Protein delivery through Extracellular Vesicles to target PCSK9
type: Dataset
applicable legislation: oj
population coverage: collection type: Other | disease: Atherosclerosis | data categories: Biological samples | materials: cDNA / mRNA,Cell lines,DNA,RNA,Tissue, cryo preserved,Other | omics: Not available | imaging: N | sex: Not available
access rights: RESTRICTED
creator: Dutch Cardiovascular Alliance (DCVA)
description: High total cholesterol levels are a major cause of disease burden in both the developed and developing world as a risk factor for ischemic heart disease and stroke. Lowering cholesterol has been one of the most effective strategy to prevent major cardiovascular event. In this study, we will try to develop a new treatment for hypercholesterolemia by permanently removing PCSK9 from hepatocytes by using cell-derived vesicles.
issued: 2019-01-01T00:00:00+00:00
language: en
modified: 2026-05-13T11:44:45.157696
provenance: ProvenanceStatement
publisher: Dutch Cardiovascular Alliance (DCVA)
spatial: NLD
temporal: PeriodOfTime
  end date: 2022-01-01T00:00:00+00:00
  start date: 2019-01-01T00:00:00+00:00
contact point: Kind
  fn: DCVA
  has URL: ']
keyword: Atherosclerosis
keyword: Biological samples
keyword: Cell lines
keyword: DNA
keyword: Not available
keyword: Other
keyword: RNA
keyword: TOP-EVs
keyword: Tissue
keyword: cDNA mRNA
keyword: cryo preserved
qualified attribution: Attribution
  agent: Dutch Cardiovascular Alliance (DCVA)
theme: HEAL

Self TRAcking for Prevention and diagnosis of heart disease
type: Dataset
applicable legislation: oj
min typical age: 18
number of unique individuals: 1200
population coverage: collection type: Hospital | disease: hartfalen | data categories: Biological samples,Imaging data,Medical records,Physiological/Biochemical measurements,Survey data,Other | materials: Feaces,Other | imaging: Y | sex: Undifferentiated
access rights: RESTRICTED
creator: Dutch Cardiovascular Alliance (DCVA)
description: We investigate diagnostic technologies to reduce cardiovascular disease. We use questionnaires, serious gaming, electrocardiography, digital stethoscopes and other eHealth techniques. Big data analytics are used to study patterns.
issued: 2020-01-01T00:00:00+00:00
language: en
modified: 2026-05-13T11:45:14.106701
provenance: ProvenanceStatement
publisher: Dutch Cardiovascular Alliance (DCVA)
spatial: NLD
temporal: PeriodOfTime
  end date: 2025-01-01T00:00:00+00:00
  start date: 2020-01-01T00:00:00+00:00
contact point: Kind
  fn: DCVA
  has URL: ']
keyword: Biological samples
keyword: Feaces
keyword: Hospital
keyword: Imaging data
keyword: Medical records
keyword: Other
keyword: Physiological Biochemical measurements
keyword: STRAP
keyword: Survey data
keyword: Undifferentiated
keyword: hartfalen
qualified attribution: Attribution
  agent: Dutch Cardiovascular Alliance (DCVA)
theme: HEAL

Detection Of Latent Pulmonary Hypertension In Genetically Susceptible Individuals
type: Dataset
applicable legislation: oj
max typical age: 78
min typical age: 20
population coverage: collection type: Cohort,Hospital,Longitudinal,Sample collection | disease: Primary pulmonary hypertension | data categories: Biological samples,Imaging data,Medical records,Survey data | materials: Peripheral blood cells,Plasma,Serum,Urine,Whole Blood | omics: Metabolomics | imaging: Y | sex: Female,Male
access rights: RESTRICTED
creator: Dutch Cardiovascular Alliance (DCVA)
description: longitudinal follow-up program for unaffected mutation carriers at risk for developing pulmonary arterial hypertension
issued: 2017-09-07T00:00:00+00:00
language: en
modified: 2026-05-13T11:45:17.470291
provenance: ProvenanceStatement
publisher: Dutch Cardiovascular Alliance (DCVA)
spatial: NLD
temporal: PeriodOfTime
  end date: 2021-09-07T00:00:00+00:00
  start date: 2017-09-07T00:00:00+00:00
contact point: Kind
  fn: DCVA
  has URL: ']
keyword: Biological samples
keyword: Cohort
keyword: DOLPHIN-GENESIS
keyword: Female
keyword: Hospital
keyword: Imaging data
keyword: Longitudinal
keyword: Male
keyword: Medical records
keyword: Metabolomics
keyword: Peripheral blood cells
keyword: Plasma
keyword: Primary pulmonary hypertension
keyword: Sample collection
keyword: Serum
keyword: Survey data
keyword: Urine
keyword: Whole Blood
qualified attribution: Attribution
  agent: Dutch Cardiovascular Alliance (DCVA)
theme: HEAL

Recognizing sudden cardiac arrest vulnerability in diabetes
type: Dataset
applicable legislation: oj
max typical age: 99
min typical age: 30
population coverage: collection type: Case-Control,Disease specific,Population-based | disease: Cardiac arrest,Type 2 diabetes mellitus | data categories: Medical records,Physiological/Biochemical measurements | materials: DNA,Plasma | omics: Genomics,Metabolomics | imaging: N | sex: Female,Male
access rights: RESTRICTED
creator: Dutch Cardiovascular Alliance (DCVA)
description: The RESCUED study investigates the risk of a sudden cardiac arrest in diabetes patients. The aim is to improve recognition of individuals at high risk of sudden cardiac arrest focussed on the General Practitioner and molecular markers.
issued: 2017-12-31T00:00:00+00:00
language: en
modified: 2026-05-13T11:46:00.941552
provenance: ProvenanceStatement
publisher: Dutch Cardiovascular Alliance (DCVA)
spatial: NLD
temporal: PeriodOfTime
  end date: 2022-12-31T00:00:00+00:00
  start date: 2017-12-31T00:00:00+00:00
contact point: Kind
  fn: DCVA
  has URL: ']
keyword: Cardiac arrest
keyword: Case-Control
keyword: DNA
keyword: Disease specific
keyword: Female
keyword: Genomics
keyword: Male
keyword: Medical records
keyword: Metabolomics
keyword: Physiological Biochemical measurements
keyword: Plasma
keyword: Population-based
keyword: RESCUED
keyword: Type 2 diabetes mellitus
qualified attribution: Attribution
  agent: Dutch Cardiovascular Alliance (DCVA)
theme: HEAL

Inflammatory Reprogramming by Ageing and Microbiome - Targets for Treatment of Cardiovascular Disease
type: Dataset
applicable legislation: oj
max typical age: 90
min typical age: 18
number of unique individuals: 1802
population coverage: collection type: Birth cohort,Cohort,Disease specific,Non-Human,Population-based | disease: Atherosclerosis,Obesity | data categories: Biological samples,Imaging data,Physiological/Biochemical measurements | materials: cDNA / mRNA,DNA,Feaces,Peripheral blood cells,Plasma,RNA,Serum,Tissue, cryo preserved,Tissue, paraffin preserved | omics: Genomics,Metabolomics,Proteomics,Transcriptomics | imaging: Y | sex: Female,Male
access rights: RESTRICTED
creator: Dutch Cardiovascular Alliance (DCVA)
description: IN-CONTROL II will seek to i. unravel the mechanisms driving 'trained immunity" in patients, taking into account the impact of senescence, age, gender and obesity, ii. elucidate the interactions between microbiome-derived signals and (immune) senescence in the etiology of obesity-related cardio-metabolic diseases, and iii. to pursue and to identify new therapeutic targets and to design novel pharmacological and microbiome-based therapies to counteract inappropriate induction of trained immunity and inflammatory processes in cardiovascular disease.
issued: 2019-05-01T00:00:00+00:00
language: en
modified: 2026-05-13T11:44:09.892836
provenance: ProvenanceStatement
publisher: Dutch Cardiovascular Alliance (DCVA)
spatial: NLD
temporal: PeriodOfTime
  end date: 2024-04-30T00:00:00+00:00
  start date: 2019-05-01T00:00:00+00:00
contact point: Kind
  fn: DCVA
  has URL: ']
keyword: Atherosclerosis
keyword: Biological samples
keyword: Birth cohort
keyword: Cohort
keyword: DNA
keyword: Disease specific
keyword: Feaces
keyword: Female
keyword: Genomics
keyword: IN-CONTROL II
keyword: Imaging data
keyword: Male
keyword: Metabolomics
keyword: Non-Human
keyword: Obesity
keyword: Peripheral blood cells
keyword: Physiological Biochemical measurements
keyword: Plasma
keyword: Population-based
keyword: Proteomics
keyword: RNA
keyword: Serum
keyword: Tissue
keyword: Transcriptomics
keyword: cDNA mRNA
keyword: cryo preserved
keyword: paraffin preserved
qualified attribution: Attribution
  agent: Dutch Cardiovascular Alliance (DCVA)
theme: HEAL

REVIVING EARLY DIAGNOSIS OF CARDIOVASCULAR DISEASE
type: Dataset
applicable legislation: oj
max typical age: 100
min typical age: 18
number of unique individuals: 650
population coverage: collection type: Cohort,Longitudinal | disease: Atherosclerotic heart disease,Heart failure,Atrial fibrillation and flutter | data categories: Biological samples,Physiological/Biochemical measurements,Survey data | materials: Serum | omics: Not available | imaging: N | sex: Female,Male
access rights: RESTRICTED
creator: Dutch Cardiovascular Alliance (DCVA)
description: A diagnostic cluster randomized trial in patients participating in primary care disease management programs for COPD or type 2 diabetes. An early diagnosis strategy will be compared with usual care (650 vs. 650 participants). primary end point: difference in number of newly diagnosed cases of heart failure, atrial fibrillation or coronary artery disease between the two arms.
issued: 2017-12-15T00:00:00+00:00
language: en
modified: 2026-05-13T11:44:12.959384
provenance: ProvenanceStatement
publisher: Dutch Cardiovascular Alliance (DCVA)
spatial: NLD
temporal: PeriodOfTime
  end date: 2022-12-15T00:00:00+00:00
  start date: 2017-12-15T00:00:00+00:00
contact point: Kind
  fn: DCVA
  has URL: ']
keyword: Atherosclerotic heart disease
keyword: Atrial fibrillation and flutter
keyword: Biological samples
keyword: Cohort
keyword: Female
keyword: Heart failure
keyword: Longitudinal
keyword: Male
keyword: Not available
keyword: Physiological Biochemical measurements
keyword: RED-CVD
keyword: Serum
keyword: Survey data
qualified attribution: Attribution
  agent: Dutch Cardiovascular Alliance (DCVA)
theme: HEAL

Cardiochirurgie registratie
type: Dataset
applicable legislation: oj
health category: Q235007
population coverage: Volwassenen van 18 jaar of ouder die een cardiochirurgische ingreep hebben ondergaan.
access rights: RESTRICTED
accrual periodicity: ANNUAL
creator: Nederlandse Hart Registratie
description: De Cardiochirurgie registratie omvat uitgevoerde cardiochirurgische ingrepen aan het hart en/of de grote intrathoracale vaten, al dan niet in combinatie met een niet-cardiale ingreep. Een sessie beslaat de periode vanaf het moment van huidincisie of -punctie tot en met het verlaten van de operatiekamer of de ruimte waar de interventie heeft plaatsgevonden. Ook afgebroken interventies nadat er al een huidincisie of -punctie heeft plaatsgevonden vallen binnen een sessie zijn geïncludeerd.
issued: 2007-01-01T00:00:00+00:00
language: NLD
modified: 2026-05-13T11:45:32.984551
provenance: ProvenanceStatement
publisher: Nederlandse Hart Registratie
spatial: NLD
temporal: PeriodOfTime
  start date: 2007-01-01T00:00:00+00:00
contact point: Kind
  fn: NHR
  has URL: ']
keyword: ATAD
keyword: AVR
keyword: CABG
keyword: CTC
keyword: MVP
keyword: MVR
keyword: aortic surgery
keyword: heart
keyword: heart valve surgery
keyword: open-heart surgery
keyword: quality registry
qualified attribution: Attribution
  agent: Nederlandse Hart Registratie
theme: HEAL

Pulmonary Hypertension and AssociatED Right heart fAilure: IMproved outcomes through Precision medicine, Advanced modelling and early deteCTion
type: Dataset
applicable legislation: oj
population coverage: collection type: Disease specific,Image collection,Non-Human,Rare disease collection | disease: Primary pulmonary hypertension | data categories: Biological samples,Imaging data,Physiological/Biochemical measurements | materials: cDNA / mRNA,Cell lines,Peripheral blood cells,Plasma,RNA,Serum,Tissue, cryo preserved,Tissue, paraffin preserved,Whole Blood | omics: Transcriptomics | imaging: Y | sex: Female,Male
access rights: RESTRICTED
creator: Dutch Cardiovascular Alliance (DCVA)
description: PAH is a deadly disease characterized by abnormal remodelling of pulmonary vessels, leading to a progressive increase in pulmonary artery pressure and right heart failure. PHAEDRA-IMPACT aims to prevent disease development by early identification of the patient at risk, and identification and treatment of treatable traits in different forms and stages of the disease.
issued: 2019-04-01T00:00:00+00:00
language: en
modified: 2026-05-13T11:45:26.047780
provenance: ProvenanceStatement
publisher: Dutch Cardiovascular Alliance (DCVA)
spatial: NLD
temporal: PeriodOfTime
  end date: 2024-04-01T00:00:00+00:00
  start date: 2019-04-01T00:00:00+00:00
contact point: Kind
  fn: DCVA
  has URL: ']
keyword: Biological samples
keyword: Cell lines
keyword: Disease specific
keyword: Female
keyword: Image collection
keyword: Imaging data
keyword: Male
keyword: Non-Human
keyword: PHAEDRA-IMPACT
keyword: Peripheral blood cells
keyword: Physiological Biochemical measurements
keyword: Plasma
keyword: Primary pulmonary hypertension
keyword: RNA
keyword: Rare disease collection
keyword: Serum
keyword: Tissue
keyword: Transcriptomics
keyword: Whole Blood
keyword: cDNA mRNA
keyword: cryo preserved
keyword: paraffin preserved
qualified attribution: Attribution
  agent: Dutch Cardiovascular Alliance (DCVA)
theme: HEAL

COroNary Calcium scoring as fiRst-linE Test to dEtect and exclude coronary artery disease in GP patients with stable chest pain
type: Dataset
applicable legislation: oj
min typical age: 40
number of unique individuals: 1600
population coverage: collection type: Other | disease: Atherosclerotic heart disease | data categories: Imaging data,Medical records | materials: Not available | omics: Not available | imaging: Y | sex: Female,Male
access rights: RESTRICTED
creator: Dutch Cardiovascular Alliance (DCVA)
description: CONCRETE aims to evaluate whether GP access to CT calcium scoring leads to earlier CAD diagnosis and treatment. The design is a pragmatic cluster randomized trial in which direct access to CT calcium scoring is compared to routine clinical care in patients with chest discomfort. Randomization will take place at GP level. Patients in both clusters will be asked for consent to fill in questionnaires and for the researchers to gather data on work-up and follow-up.
issued: 2017-12-15T00:00:00+00:00
language: en
modified: 2026-05-13T11:45:50.930018
provenance: ProvenanceStatement
publisher: Dutch Cardiovascular Alliance (DCVA)
spatial: NLD
temporal: PeriodOfTime
  end date: 2022-12-14T00:00:00+00:00
  start date: 2017-12-15T00:00:00+00:00
contact point: Kind
  fn: DCVA
  has URL: ']
keyword: Atherosclerotic heart disease
keyword: CONCRETE
keyword: Female
keyword: Imaging data
keyword: Male
keyword: Medical records
keyword: Not available
keyword: Other
qualified attribution: Attribution
  agent: Dutch Cardiovascular Alliance (DCVA)
theme: HEAL

CAPACITY 2: A prospective cohort study evaluating the occurrence of short and long-term cardiac and cerebrovascular complications in patients hospitalized for COVID-19
type: Dataset
applicable legislation: oj
max typical age: 70
min typical age: 19
number of unique individuals: 193
population coverage: collection type: Cohort,Disease specific,Hospital,Longitudinal | data categories: Imaging data,Medical records,Physiological/Biochemical measurements,Survey data | materials: Not available | omics: Not available | imaging: Y | sex: Female,Male
access rights: RESTRICTED
creator: Dutch Cardiovascular Alliance (DCVA)
description: For this reason, there is an urgent need for large prospective cohort studies in which patients with laboratory confirmed COVID-19 unselectively undergo standardized and long-term follow-up to assess the occurrence and natural history of cardiac abnormalities. In the current study, we aim to determine if and how often (residual) cardiac damage can be detected in patients who have recovered from COVID-19. Furthermore, we strive to gain additional insight into the etiology in patients that develop (residual) damage of the heart.
issued: 2021-03-01T00:00:00+00:00
language: en
modified: 2026-05-13T11:44:16.227911
provenance: ProvenanceStatement
publisher: Dutch Cardiovascular Alliance (DCVA)
spatial: NLD
temporal: PeriodOfTime
  start date: 2021-03-01T00:00:00+00:00
contact point: Kind
  fn: DCVA
  has URL: ']
keyword: CAPACITY2
keyword: Cohort
keyword: Disease specific
keyword: Female
keyword: Hospital
keyword: Imaging data
keyword: Longitudinal
keyword: Male
keyword: Medical records
keyword: Not available
keyword: Physiological Biochemical measurements
keyword: Survey data
qualified attribution: Attribution
  agent: Dutch Cardiovascular Alliance (DCVA)
theme: HEAL

IMPRESS
type: Dataset
applicable legislation: oj
number of unique individuals: 88
population coverage: collection type: Cohort,Disease specific,Hospital,Sample collection | data categories: Biological samples,Medical records | materials: cDNA / mRNA,Peripheral blood cells,Plasma,RNA,Whole Blood | omics: Not available | imaging: N | sex: Female
access rights: RESTRICTED
creator: Dutch Cardiovascular Alliance (DCVA)
description: This project aims at investigating if the mechanism of trained immunity plays a role in the development of atherosclerosis in women with former preeclampsia.
issued: 2026-05-13T09:58:36.953780
language: en
modified: 2026-05-13T11:43:44.038847
provenance: ProvenanceStatement
publisher: Dutch Cardiovascular Alliance (DCVA)
spatial: NLD
contact point: Kind
  fn: DCVA
  has URL: ']
keyword: Biological samples
keyword: Cohort
keyword: Disease specific
keyword: Female
keyword: Hospital
keyword: IMPRESS
keyword: Medical records
keyword: Not available
keyword: Peripheral blood cells
keyword: Plasma
keyword: RNA
keyword: Sample collection
keyword: Whole Blood
keyword: cDNA mRNA
qualified attribution: Attribution
  agent: Dutch Cardiovascular Alliance (DCVA)
theme: HEAL

UNRAVELLING AETIOLOGY AND RISK FACTORS IN PATIENTS WITH A BICUSPID AORTIC VALVES
type: Dataset
applicable legislation: oj
max typical age: 40
min typical age: 18
population coverage: collection type: Disease specific,Hospital,Image collection,Longitudinal,Non-Human,Rare disease collection | disease: Congenital insufficiency of aortic valve | data categories: Biological samples,Imaging data,Medical records | materials: DNA,Plasma,Serum | omics: Genomics | imaging: Y | sex: Female,Male
access rights: RESTRICTED
creator: Dutch Cardiovascular Alliance (DCVA)
description: The bicuspid aortic valve is generally considered to be a result of a congenital fusion of two out of three leaflets. We found that the non-coronary leaflet develops from the same embryonic structure that also gives rise to the right coronary leaflet. A BAV type 2 can be considered as the result of an improper separation rather than an abnormal fusion of two separately developed leaflets, which is an essential different starting point for our research to explore the genetic and signalling pathways of BAV genesis. We also have found in a bicuspid aortic model (NOS3 knock out) that 2 out 3 contributing extracardiac cell populations (neural crest and second heart field) are disturbed in their contribution to both the aortic valvular leaflets and the aorta wall. This results in BAV and abnormal elastin production in the ascending aortic wall from its initial formation in the embryo onwards. Hemodynamics seems to play a more modest role in the formation of the aorta aneurysm than one has generally considered up till now. To study the role of haemodynamics in EMT during valve formation and calcification we made use of the ex vivo miniature tissue culture system. In cultured mouse adult hearts, we found that by changing flow, the response of valve endothelial cells is altered. By culturing valves of mice with a genetic endothelial lineage trace, we could show that when exposed to high physiological flow, the endothelial cell phenotype and lining is maintained. Interestingly, by adding calcification inducing factors such as B-glycerolphosphate, dexamethasone or Bone Morphogenetic Proteins, we were able to induce valvular calcification in the cultured adult mouse hearts. We further studied the role of haemodynamics in the pathology of BAV by immunoshistochemical analysis of aortic material. We observed that at the non-jet side of the aorta the endothelial cells showed a significantly increased inflammation (P50+), endothelial-to-mesenchymal-transition (SNAI1+) and trend towa…
issued: 2014-05-01T00:00:00+00:00
language: en
modified: 2026-05-13T11:47:32.195575
provenance: ProvenanceStatement
publisher: Dutch Cardiovascular Alliance (DCVA)
spatial: NLD
temporal: PeriodOfTime
  end date: 2019-05-01T00:00:00+00:00
  start date: 2014-05-01T00:00:00+00:00
contact point: Kind
  fn: DCVA
  has URL: ']
keyword: BAV
keyword: Biological samples
keyword: Congenital insufficiency of aortic valve
keyword: DNA
keyword: Disease specific
keyword: Female
keyword: Genomics
keyword: Hospital
keyword: Image collection
keyword: Imaging data
keyword: Longitudinal
keyword: Male
keyword: Medical records
keyword: Non-Human
keyword: Plasma
keyword: Rare disease collection
keyword: Serum
qualified attribution: Attribution
  agent: Dutch Cardiovascular Alliance (DCVA)
theme: HEAL

Lifestyle Innovations Based on youth's Knowledge and Experience
type: Dataset
applicable legislation: oj
max typical age: 14
min typical age: 10
number of unique individuals: 2
population coverage: collection type: Other | disease: Obesity | data categories: Medical records,Survey data | materials: Not available | omics: Not available | imaging: N | sex: Female,Male
access rights: RESTRICTED
creator: Dutch Cardiovascular Alliance (DCVA)
description: In the five year LIKE programme (2017-2022), we develop, implement and evaluate an integrated action programme at the level of family, school, neighbourhood, health care and city, based upon a detailed insight into the characteristics of the population at stake. The aim is to tackle the wicked problem of childhood overweight and obesity in 10-14 year old adolescents in Amsterdam, using a systems dynamics and participatory approach. Following the principles of Participatory Action Research (PAR), we work with our population (adolescents and their families) and societal stakeholders as co-creators and co-investigators.
issued: 2017-07-01T00:00:00+00:00
language: en
modified: 2026-05-13T11:46:32.890708
provenance: ProvenanceStatement
publisher: Dutch Cardiovascular Alliance (DCVA)
spatial: NLD
temporal: PeriodOfTime
  end date: 2022-07-01T00:00:00+00:00
  start date: 2017-07-01T00:00:00+00:00
contact point: Kind
  fn: DCVA
  has URL: ']
keyword: Female
keyword: LIKE
keyword: Male
keyword: Medical records
keyword: Not available
keyword: Obesity
keyword: Other
keyword: Survey data
qualified attribution: Attribution
  agent: Dutch Cardiovascular Alliance (DCVA)
theme: HEAL

Device-based rate versus rhythm control treatment in patients with symptomatic recent-onset atrial fibrillation in the emergency department (RACE 9)
type: Dataset
applicable legislation: oj
max typical age: 81
min typical age: 50
number of unique individuals: 0
population coverage: collection type: Disease specific,Hospital,Longitudinal | disease: I48.0 Atriumfibrilleren | data categories: Biological samples,Medical records | materials: Plasma,Whole Blood | omics: Not available | imaging: N | sex: Female,Male
access rights: RESTRICTED
creator: Dutch Cardiovascular Alliance (DCVA)
description: multicenter, prospective randomised controlled trial to evaluate the efficacy of a watchful waiting strategy (rate control for symptom relief) compared to routine care (cardioversion) for patients with recent-onset symptomatic paroxysmal atrial fibrillation presenting to the emergency department.
issued: 2020-11-01T00:00:00+00:00
language: en
modified: 2026-05-13T11:47:22.424421
provenance: ProvenanceStatement
publisher: Dutch Cardiovascular Alliance (DCVA)
spatial: NLD
temporal: PeriodOfTime
  start date: 2020-11-01T00:00:00+00:00
contact point: Kind
  fn: DCVA
  has URL: ']
keyword: Biological samples
keyword: Disease specific
keyword: Female
keyword: Hospital
keyword: I48.0 Atriumfibrilleren
keyword: Longitudinal
keyword: Male
keyword: Medical records
keyword: Not available
keyword: Plasma
keyword: RACE 9 Observe-AF
keyword: Whole Blood
qualified attribution: Attribution
  agent: Dutch Cardiovascular Alliance (DCVA)
theme: HEAL

PCI registratie
type: Dataset
applicable legislation: oj
health category: Q10379
population coverage: Volwassenen van 18 jaar of ouder die een PCI hebben ondergaan.
access rights: RESTRICTED
accrual periodicity: ANNUAL
creator: Nederlandse Hart Registratie
description: De Percutane Coronaire Interventie (PCI) registratie omvat elke interventie waarbij een instrument (guide wire, ballon, trombosuctie katheter, rotablator, etc.) in één van de coronairen of in de coronaire arteriële bypass graft ingebracht wordt met de intentie om het desbetreffende bloedvat te behandelen. De geïsoleerde diagnostische metingen zijn niet geïncludeerd.
issued: 2013-01-01T00:00:00+00:00
language: NLD
modified: 2026-05-13T11:44:19.599958
provenance: ProvenanceStatement
publisher: Nederlandse Hart Registratie
spatial: NLD
temporal: PeriodOfTime
  start date: 2013-01-01T00:00:00+00:00
contact point: Kind
  fn: NHR
  has URL: ']
keyword: CAD
keyword: Coronary artery disease
keyword: Interventional cardiology
keyword: NSTEMI
keyword: PCI
keyword: Percutaneous coronary intervention
keyword: STEMI
keyword: heart
keyword: quality registry
keyword: stent
qualified attribution: Attribution
  agent: Nederlandse Hart Registratie
theme: HEAL

ESCAPE-HF
type: Dataset
applicable legislation: oj
population coverage: collection type: Other | disease: Heart failure | data categories: Other | materials: Not available | omics: Not available | imaging: N | sex: Female,Male
access rights: RESTRICTED
creator: Dutch Cardiovascular Alliance (DCVA)
description: large small molecule screen to identify compounds that enhance 5-oxoprolinase activity.
issued: 2019-04-01T00:00:00+00:00
language: en
modified: 2026-05-13T11:47:26.711430
provenance: ProvenanceStatement
publisher: Dutch Cardiovascular Alliance (DCVA)
spatial: NLD
temporal: PeriodOfTime
  end date: 2022-04-01T00:00:00+00:00
  start date: 2019-04-01T00:00:00+00:00
contact point: Kind
  fn: DCVA
  has URL: ']
keyword: ESCAPE-HF
keyword: Female
keyword: Heart failure
keyword: Male
keyword: Not available
keyword: Other
qualified attribution: Attribution
  agent: Dutch Cardiovascular Alliance (DCVA)
theme: HEAL

Determination and Evaluation of the Frequency and Effects of myocardial damage iN patients with aSARS-CoV-2 infEction
type: Dataset
applicable legislation: oj
max typical age: 107
min typical age: 18
population coverage: collection type: Cohort,Cross-sectional,Hospital,Longitudinal,Population-based | disease: Diseases of the circulatory system | data categories: Imaging data,Medical records,National registries,Survey data | materials: Not available | omics: Not available | imaging: Y | sex: Female,Male
access rights: RESTRICTED
creator: Dutch Cardiovascular Alliance (DCVA)
description: Within DEFENCE, all large national COVID-19 studies aimed at unravelling the relationship between cardiovascular disease and COVID-19 are brought together. The main aim of DEFENCE is to unravel the prevalence and consequences of myocardial damage of COVID-19.
is referenced by: https://pubmed.ncbi.nlm.nih.gov/35266090/
is referenced by: https://pubmed.ncbi.nlm.nih.gov/35820692/
is referenced by: https://pubmed.ncbi.nlm.nih.gov/36043214/
issued: 2021-10-01T00:00:00+00:00
language: en
modified: 2026-05-13T11:45:22.651475
provenance: ProvenanceStatement
publisher: Dutch Cardiovascular Alliance (DCVA)
spatial: NLD
temporal: PeriodOfTime
  end date: 2024-09-30T00:00:00+00:00
  start date: 2021-10-01T00:00:00+00:00
contact point: Kind
  fn: DCVA
  has URL: ']
keyword: Cohort
keyword: Cross-sectional
keyword: DEFENCE
keyword: Diseases of the circulatory system
keyword: Female
keyword: Hospital
keyword: Imaging data
keyword: Longitudinal
keyword: Male
keyword: Medical records
keyword: National registries
keyword: Not available
keyword: Population-based
keyword: Survey data
qualified attribution: Attribution
  agent: Dutch Cardiovascular Alliance (DCVA)
theme: HEAL

Heart-Brain Connection & Heart-Brain Connection - crossroads
type: Dataset
applicable legislation: oj
max typical age: 92
min typical age: 50
number of unique individuals: 566
population coverage: collection type: Cohort,Cross-sectional,Disease specific,Hospital,Image collection,Longitudinal,Population-based | disease: Atrial fibrillation and flutter,Occlusion and stenosis of carotid artery,Heart failure,Other and unspecified symptoms and signs involving cognitive functions and awareness | data categories: Biological samples,Imaging data,Physiological/Biochemical measurements,Survey data,Other | materials: Liquor,Plasma,Serum | omics: Not available | imaging: Y | sex: Female,Male
access rights: RESTRICTED
creator: Dutch Cardiovascular Alliance (DCVA)
description: Cognitive impairment is common among people with cardiovascular or cerebrovascular disease. HBC1 explored the etiological role of hemodynamic factors in cognitive impairment, particularly addressing flow. HBCx builds on the same hypothesis, now taking a multidimensional approach, also addressing flow regulation and variability and factors that modulate the impact of hemodynamic disturbances.
issued: 2019-09-01T00:00:00+00:00
language: en
modified: 2026-05-13T11:43:40.064920
provenance: ProvenanceStatement
publisher: Dutch Cardiovascular Alliance (DCVA)
spatial: NLD
temporal: PeriodOfTime
  end date: 2024-09-01T00:00:00+00:00
  start date: 2019-09-01T00:00:00+00:00
contact point: Kind
  fn: DCVA
  has URL: ']
keyword: Atrial fibrillation and flutter
keyword: Biological samples
keyword: Cohort
keyword: Cross-sectional
keyword: Disease specific
keyword: Female
keyword: HBC HBCx
keyword: Heart failure
keyword: Hospital
keyword: Image collection
keyword: Imaging data
keyword: Liquor
keyword: Longitudinal
keyword: Male
keyword: Not available
keyword: Occlusion and stenosis of carotid artery
keyword: Other
keyword: Other and unspecified symptoms and signs involving cognitive functions and awareness
keyword: Physiological Biochemical measurements
keyword: Plasma
keyword: Population-based
keyword: Serum
keyword: Survey data
qualified attribution: Attribution
  agent: Dutch Cardiovascular Alliance (DCVA)
theme: HEAL

DETECTIN-HF
type: Dataset
applicable legislation: oj
number of unique individuals: 5050
population coverage: collection type: Cohort,Disease specific,Rare disease collection,Sample collection | disease: Dilated cardiomyopathy | data categories: Biological samples,Imaging data,Medical records,National registries,Physiological/Biochemical measurements | materials: DNA,Plasma,Serum | omics: Genomics | imaging: Y | sex: Female,Male
access rights: RESTRICTED
creator: Dutch Cardiovascular Alliance (DCVA)
description: Dilated cardiomyopathy is a major cause of heart failure and is the main indication of cardiac transplantation. About 30-50% of the cases can be explained by genetic predisposition. However, the precise mechanisms that lead to variations in disease susceptibility and phenotype presentation including risk for heart failure or sudden cardiac death are thus far unknown. The DETECTIN-HF project will work with selected clinical and molecular markers in a multi-center, multi-national cohort. The facility which arises by creating this single, harmonized portal is unique in setup and scale and is invaluable for research and improved clinical practice.
issued: 2016-06-01T00:00:00+00:00
language: en
modified: 2026-05-13T11:46:47.965317
provenance: ProvenanceStatement
publisher: Dutch Cardiovascular Alliance (DCVA)
spatial: NLD
temporal: PeriodOfTime
  end date: 2021-06-01T00:00:00+00:00
  start date: 2016-06-01T00:00:00+00:00
contact point: Kind
  fn: DCVA
  has URL: ']
keyword: Biological samples
keyword: Cohort
keyword: DETECTIN-HF
keyword: DNA
keyword: Dilated cardiomyopathy
keyword: Disease specific
keyword: Female
keyword: Genomics
keyword: Imaging data
keyword: Male
keyword: Medical records
keyword: National registries
keyword: Physiological Biochemical measurements
keyword: Plasma
keyword: Rare disease collection
keyword: Sample collection
keyword: Serum
qualified attribution: Attribution
  agent: Dutch Cardiovascular Alliance (DCVA)
theme: HEAL

MyDigiTwin: Using Big-Data to put a cardiovascular digital twin into the hands of people.
type: Dataset
applicable legislation: oj
min typical age: 18
population coverage: collection type: Hospital | data categories: Imaging data,Medical records,National registries,Physiological/Biochemical measurements,Survey data,Other | imaging: Y | sex: Undifferentiated
access rights: RESTRICTED
creator: Dutch Cardiovascular Alliance (DCVA)
description: The MyDigiTwin consortium will build the MyDigiTwin platform on top of the Personal health record depositories (Dutch: Persoonlijke Gezondheidsomgeving; PGO), enabling users to build "digital twins" of themselves with their personal health data in order to gain a better understanding of their (heart) health, but also the effect of possible lifestyle changes. Through MyDigiTwin, users can perform analyses with their own data, take control of their own health monitoring, detect possible risks of heart disease at an early stage and go to a doctor in time.
issued: 2020-01-01T00:00:00+00:00
language: en
modified: 2026-05-13T11:45:07.905588
provenance: ProvenanceStatement
publisher: Dutch Cardiovascular Alliance (DCVA)
spatial: NLD
temporal: PeriodOfTime
  end date: 2025-01-01T00:00:00+00:00
  start date: 2020-01-01T00:00:00+00:00
contact point: Kind
  fn: DCVA
  has URL: ']
keyword: Hospital
keyword: Imaging data
keyword: Medical records
keyword: MyDigiTwin
keyword: National registries
keyword: Other
keyword: Physiological Biochemical measurements
keyword: Survey data
keyword: Undifferentiated
qualified attribution: Attribution
  agent: Dutch Cardiovascular Alliance (DCVA)
theme: HEAL

PREDICT2
type: Dataset
applicable legislation: oj
max typical age: 83
min typical age: 3
population coverage: collection type: Case-Control,Cohort,Disease specific,Hospital,Population-based,Rare disease collection | disease: Cardiac arrhythmia, unspecified | data categories: Biological samples,Medical records,National registries,Physiological/Biochemical measurements | materials: Buccal Swab,cDNA / mRNA,microRNA | omics: Proteomics | imaging: N | sex: Undifferentiated
access rights: RESTRICTED
creator: Dutch Cardiovascular Alliance (DCVA)
description: To improve treatment of ventricular arrhythmias, research is conducted on many different levels: genetics, basic and clinical electrophysiology, national registries, human samples.
issued: 2019-02-01T00:00:00+00:00
language: en
modified: 2026-05-13T11:43:46.258539
provenance: ProvenanceStatement
publisher: Dutch Cardiovascular Alliance (DCVA)
spatial: NLD
temporal: PeriodOfTime
  end date: 2023-08-01T00:00:00+00:00
  start date: 2019-02-01T00:00:00+00:00
contact point: Kind
  fn: DCVA
  has URL: ']
keyword: Biological samples
keyword: Buccal Swab
keyword: Cardiac arrhythmia
keyword: Case-Control
keyword: Cohort
keyword: Disease specific
keyword: Hospital
keyword: Medical records
keyword: National registries
keyword: PREDICT2
keyword: Physiological Biochemical measurements
keyword: Population-based
keyword: Proteomics
keyword: Rare disease collection
keyword: Undifferentiated
keyword: cDNA mRNA
keyword: microRNA
keyword: unspecified
qualified attribution: Attribution
  agent: Dutch Cardiovascular Alliance (DCVA)
theme: HEAL

WOMB project: Women Offspring and iMproving lifestyle for Better cardiovascular health of Both
type: Dataset
applicable legislation: oj
max typical age: 45
min typical age: 3
number of unique individuals: 577
population coverage: collection type: Longitudinal | disease: Obesity,Primary pulmonary hypertension,Disorders of lipoprotein metabolism and other lipidaemias - Pure hypercholesterolaemia,Mood [affective] disorders | data categories: Biological samples,Imaging data,Physiological/Biochemical measurements,Survey data | materials: Buccal Swab,Feaces,Peripheral blood cells,Plasma | omics: Metabolomics | imaging: Y | sex: Female,Male
access rights: RESTRICTED
creator: Dutch Cardiovascular Alliance (DCVA)
description: Follow up of women (with obesity and unfulfilled wish for a child) and their children who participated in a preconception lifestyle intervention with focus on women's lifestyle, health and wellbeing and child growth, development, behavior and health (including cardiac ultrasound and MRI in children)
issued: 2014-09-01T00:00:00+00:00
language: en
modified: 2026-05-13T11:47:37.865738
provenance: ProvenanceStatement
publisher: Dutch Cardiovascular Alliance (DCVA)
spatial: NLD
temporal: PeriodOfTime
  end date: 2020-09-01T00:00:00+00:00
  start date: 2014-09-01T00:00:00+00:00
contact point: Kind
  fn: DCVA
  has URL: ']
keyword: Biological samples
keyword: Buccal Swab
keyword: Disorders of lipoprotein metabolism and other lipidaemias - Pure hypercholesterolaemia
keyword: Feaces
keyword: Female
keyword: Imaging data
keyword: Longitudinal
keyword: Male
keyword: Metabolomics
keyword: Mood affective disorders
keyword: Obesity
keyword: Peripheral blood cells
keyword: Physiological Biochemical measurements
keyword: Plasma
keyword: Primary pulmonary hypertension
keyword: Survey data
keyword: WOMB
qualified attribution: Attribution
  agent: Dutch Cardiovascular Alliance (DCVA)
theme: HEAL

RADAR: Earlier Recognition of Aortic Dissection and Aneurysm Rupture: The RADAR Study
type: Dataset
applicable legislation: oj
population coverage: collection type: Cross-sectional,Disease specific,Hospital,Longitudinal | disease: Aortic aneurysm of unspecified site, without mention of rupture | data categories: Imaging data,Medical records,Physiological/Biochemical measurements | materials: Not available | omics: Not available | imaging: Y | sex: Female,Male
access rights: RESTRICTED
creator: Dutch Cardiovascular Alliance (DCVA)
description: Aortic aneurysm is a life-threatening condition. When undetected, an aneurysm can grow and evolve into dissection or rupture. This RADAR-consortium will develop methods to detect aneurysms earlier. The techniques rely on multi-parametric MRI to evaluate aortic morphology, aortic vessel wall and blood flow, and computational fluid dynamics for blood pressure and wall shear stress.
issued: 2017-12-15T00:00:00+00:00
language: en
modified: 2026-05-13T11:46:39.842705
provenance: ProvenanceStatement
publisher: Dutch Cardiovascular Alliance (DCVA)
spatial: NLD
temporal: PeriodOfTime
  end date: 2022-12-15T00:00:00+00:00
  start date: 2017-12-15T00:00:00+00:00
contact point: Kind
  fn: DCVA
  has URL: ']
keyword: Aortic aneurysm of unspecified site
keyword: Cross-sectional
keyword: Disease specific
keyword: Female
keyword: Hospital
keyword: Imaging data
keyword: Longitudinal
keyword: Male
keyword: Medical records
keyword: Not available
keyword: Physiological Biochemical measurements
keyword: RADAR
keyword: without mention of rupture
qualified attribution: Attribution
  agent: Dutch Cardiovascular Alliance (DCVA)
theme: HEAL

BRAIN@Risk
type: Dataset
applicable legislation: oj
population coverage: collection type: Disease specific,Rare disease collection | disease: Cerebrovascular diseases | data categories: Imaging data | materials: Not available | omics: Not available | imaging: Y | sex: Female,Male
access rights: RESTRICTED
creator: Dutch Cardiovascular Alliance (DCVA)
description: Functional and structural MRI biomarkers of large and small vessel disease of the cerebral vasculature.
issued: 2017-03-01T00:00:00+00:00
language: en
modified: 2026-05-13T11:44:32.625987
provenance: ProvenanceStatement
publisher: Dutch Cardiovascular Alliance (DCVA)
spatial: NLD
temporal: PeriodOfTime
  end date: 2021-03-01T00:00:00+00:00
  start date: 2017-03-01T00:00:00+00:00
contact point: Kind
  fn: DCVA
  has URL: ']
keyword: BRAIN Risk
keyword: Cerebrovascular diseases
keyword: Disease specific
keyword: Female
keyword: Imaging data
keyword: Male
keyword: Not available
keyword: Rare disease collection
qualified attribution: Attribution
  agent: Dutch Cardiovascular Alliance (DCVA)
theme: HEAL

Aangeboren hartafwijkingen, en verworven hartafwijkingen bij kinderen registratie
type: Dataset
applicable legislation: oj
health category: Q10379
population coverage: Patiënten (kinderen en volwassenen) met een aangeboren hartafwijking, en kinderen (jonger dan 18 jaar) met een verworven hartafwijking.
access rights: RESTRICTED
accrual periodicity: ANNUAL
creator: Nederlandse Hart Registratie
description: De registratie Aangeboren hartafwijkingen, en verworven hartafwijkingen bij kinderen (AHVHK) omvat patiënten (zowel kind als volwassenen) met een aangeboren hartafwijking, en kinderen met een verworven hartafwijking. De patiënten binnen deze registratie worden geïncludeerd op basis van hun diagnose. Deze registratie omvat daarnaast ook alle hartkatheterisaties bij kinderen.
issued: 2015-01-01T00:00:00+00:00
language: NLD
modified: 2026-05-13T11:46:36.991559
provenance: ProvenanceStatement
publisher: Nederlandse Hart Registratie
spatial: NLD
temporal: PeriodOfTime
  start date: 2015-01-01T00:00:00+00:00
contact point: Kind
  fn: NHR
  has URL: ']
keyword: ASD
keyword: TGA
keyword: Tetralogy of Fallot
keyword: VSD
keyword: congenital heart disease CHD
keyword: quality registry
qualified attribution: Attribution
  agent: Nederlandse Hart Registratie
theme: HEAL

EaRly diagnosis of Stable and Unstable Angina uSIng extracellular VEsicles
type: Dataset
applicable legislation: oj
max typical age: 96
min typical age: 19
number of unique individuals: 3300
population coverage: collection type: Case-Control,Cohort,Disease specific,Hospital | disease: Angina pectoris,Unstable angina | data categories: Biological samples,Imaging data,Medical records | materials: Plasma | omics: Proteomics | imaging: Y | sex: Female,Male
access rights: RESTRICTED
creator: Dutch Cardiovascular Alliance (DCVA)
description: Extracellular vesicle proteins in plasma subfractions are investigated to determine their ability for early diagnosis of stable and unstable angina using a blood test
issued: 2017-12-01T00:00:00+00:00
language: en
modified: 2026-05-13T11:45:38.527938
provenance: ProvenanceStatement
publisher: Dutch Cardiovascular Alliance (DCVA)
spatial: NLD
temporal: PeriodOfTime
  end date: 2021-03-01T00:00:00+00:00
  start date: 2017-12-01T00:00:00+00:00
contact point: Kind
  fn: DCVA
  has URL: ']
keyword: Angina pectoris
keyword: Biological samples
keyword: Case-Control
keyword: Cohort
keyword: Disease specific
keyword: Female
keyword: Hospital
keyword: Imaging data
keyword: Male
keyword: Medical records
keyword: Plasma
keyword: Proteomics
keyword: Unstable angina
keyword: pERSUASIVE
qualified attribution: Attribution
  agent: Dutch Cardiovascular Alliance (DCVA)
theme: HEAL

GeranylGeranylAcetone in Heart failure with preserved ejection fraction
type: Dataset
applicable legislation: oj
min typical age: 50
number of unique individuals: 40
population coverage: collection type: Disease specific,Hospital,Image collection,Longitudinal,Sample collection | disease: HFpEF | data categories: Biological samples,Imaging data,Medical records | materials: Plasma,Serum,Urine | imaging: Y | sex: Female,Male
access rights: RESTRICTED
creator: Dutch Cardiovascular Alliance (DCVA)
description: In this phase 2 trial, we expect to obtain proof of concept for a beneficial effect of GGA on HFpEF. In HFpEF patients we will evaluate effects of GGA on signs and symptoms of HFpEF including echographic parameters of diastolic function, exercise tolerance, microvascular endothelial function and kidney function.
issued: 2021-07-01T00:00:00+00:00
language: en
modified: 2026-05-13T11:45:04.986036
provenance: ProvenanceStatement
publisher: Dutch Cardiovascular Alliance (DCVA)
spatial: NLD
temporal: PeriodOfTime
  end date: 2026-07-01T00:00:00+00:00
  start date: 2021-07-01T00:00:00+00:00
contact point: Kind
  fn: DCVA
  has URL: ']
keyword: Biological samples
keyword: Disease specific
keyword: Female
keyword: GLADIATOR-HFpEF part of RECONNEXT
keyword: HFpEF
keyword: Hospital
keyword: Image collection
keyword: Imaging data
keyword: Longitudinal
keyword: Male
keyword: Medical records
keyword: Plasma
keyword: Sample collection
keyword: Serum
keyword: Urine
qualified attribution: Attribution
  agent: Dutch Cardiovascular Alliance (DCVA)
theme: HEAL

ENERGISE, Targeting energy metabolism to combat cardiovascular disease
type: Dataset
applicable legislation: oj
max typical age: 75
min typical age: 18
population coverage: collection type: Case-Control,Cohort,Cross-sectional,Non-Human,Population-based,Sample collection | disease: Obesity,Type 2 diabetes mellitus | data categories: Biological samples,Imaging data,Physiological/Biochemical measurements,Survey data | materials: cDNA / mRNA,Cell lines,DNA,Peripheral blood cells,Plasma,RNA,Serum,Tissue, cryo preserved | omics: Metabolomics,Transcriptomics | imaging: Y | sex: Female,Male
access rights: RESTRICTED
creator: Dutch Cardiovascular Alliance (DCVA)
description: this is not one project but a collection of cohort studies, human experimental words and much more
issued: 2015-09-01T00:00:00+00:00
language: en
modified: 2026-05-13T11:45:55.506411
provenance: ProvenanceStatement
publisher: Dutch Cardiovascular Alliance (DCVA)
spatial: NLD
temporal: PeriodOfTime
  end date: 2020-08-31T00:00:00+00:00
  start date: 2015-09-01T00:00:00+00:00
contact point: Kind
  fn: DCVA
  has URL: ']
keyword: Biological samples
keyword: Case-Control
keyword: Cell lines
keyword: Cohort
keyword: Cross-sectional
keyword: DNA
keyword: Energise
keyword: Female
keyword: Imaging data
keyword: Male
keyword: Metabolomics
keyword: Non-Human
keyword: Obesity
keyword: Peripheral blood cells
keyword: Physiological Biochemical measurements
keyword: Plasma
keyword: Population-based
keyword: RNA
keyword: Sample collection
keyword: Serum
keyword: Survey data
keyword: Tissue
keyword: Transcriptomics
keyword: Type 2 diabetes mellitus
keyword: cDNA mRNA
keyword: cryo preserved
qualified attribution: Attribution
  agent: Dutch Cardiovascular Alliance (DCVA)
theme: HEAL

Digoxin Evaluation in Chronic heart failure: Investigational Study In Outpatients in the Netherlands
type: Dataset
applicable legislation: oj
population coverage: collection type: Case-Control,Disease specific,Hospital | disease: Heart failure | data categories: Physiological/Biochemical measurements | materials: Not available | omics: Not available | imaging: N | sex: Female,Male
access rights: RESTRICTED
creator: Dutch Cardiovascular Alliance (DCVA)
description: To invetigate if Low-dose Digoxin can effectively reduce cardiovascular mortality and recurrent HF hospitalizations, on top of the guideline-recommended therapies in HF patients with LVEF<50%
issued: 2020-04-01T00:00:00+00:00
language: en
modified: 2026-05-13T11:46:45.912692
provenance: ProvenanceStatement
publisher: Dutch Cardiovascular Alliance (DCVA)
spatial: NLD
temporal: PeriodOfTime
  end date: 2020-03-31T00:00:00+00:00
  start date: 2020-04-01T00:00:00+00:00
contact point: Kind
  fn: DCVA
  has URL: ']
keyword: Case-Control
keyword: DECISION
keyword: Disease specific
keyword: Female
keyword: Heart failure
keyword: Hospital
keyword: Male
keyword: Not available
keyword: Physiological Biochemical measurements
qualified attribution: Attribution
  agent: Dutch Cardiovascular Alliance (DCVA)
theme: HEAL

Race V - Poaf
type: Dataset
applicable legislation: oj
max typical age: 78
min typical age: 45
number of unique individuals: 168
population coverage: collection type: Hospital,Longitudinal,Sample collection | disease: Atrial fibrillation and atrial flutter, unspecified | data categories: Biological samples,Imaging data,Medical records,Physiological/Biochemical measurements,Survey data | materials: cDNA / mRNA,Plasma,RNA,Serum,Tissue, cryo preserved,Whole Blood | omics: Genomics,Proteomics,Transcriptomics | imaging: Y | sex: Female,Male
access rights: RESTRICTED
creator: Dutch Cardiovascular Alliance (DCVA)
description: primary aim: study molecular mechanisms of AF by combining histology, biochemical analysis, and genome-wide RNA expression profiles. Secondary aim: study the incidence of AF during the first years after cardiac surgery in patients with or without a history of AF
issued: 2016-10-01T00:00:00+00:00
language: en
modified: 2026-05-13T11:47:14.722221
provenance: ProvenanceStatement
publisher: Dutch Cardiovascular Alliance (DCVA)
spatial: NLD
temporal: PeriodOfTime
  end date: 2022-10-01T00:00:00+00:00
  start date: 2016-10-01T00:00:00+00:00
contact point: Kind
  fn: DCVA
  has URL: ']
keyword: Atrial fibrillation and atrial flutter
keyword: Biological samples
keyword: Female
keyword: Genomics
keyword: Hospital
keyword: Imaging data
keyword: Longitudinal
keyword: Male
keyword: Medical records
keyword: Physiological Biochemical measurements
keyword: Plasma
keyword: Proteomics
keyword: RNA
keyword: Sample collection
keyword: Serum
keyword: Survey data
keyword: Tissue
keyword: Transcriptomics
keyword: Whole Blood
keyword: cDNA mRNA
keyword: cryo preserved
keyword: unspecified
qualified attribution: Attribution
  agent: Dutch Cardiovascular Alliance (DCVA)
theme: HEAL

Video monitoring FOR early Signaling of adverse EvEnts
type: Dataset
applicable legislation: oj
min typical age: 18
population coverage: collection type: Hospital,Image collection | data categories: Medical records,Other | materials: Not available | omics: Not available | imaging: Y | sex: Female,Male
access rights: RESTRICTED
creator: Dutch Cardiovascular Alliance (DCVA)
description: This project explores continuous video monitoring of the cardiorespiratory status of a patient as an innovative unobtrusive method that could aid to reduce workload for the staff and better predict deterioration.
issued: 2020-09-01T00:00:00+00:00
language: en
modified: 2026-05-13T11:43:55.502103
provenance: ProvenanceStatement
publisher: Dutch Cardiovascular Alliance (DCVA)
spatial: NLD
temporal: PeriodOfTime
  end date: 2024-09-01T00:00:00+00:00
  start date: 2020-09-01T00:00:00+00:00
contact point: Kind
  fn: DCVA
  has URL: ']
keyword: FORSEE
keyword: Female
keyword: Hospital
keyword: Image collection
keyword: Male
keyword: Medical records
keyword: Not available
keyword: Other
qualified attribution: Attribution
  agent: Dutch Cardiovascular Alliance (DCVA)
theme: HEAL

https://fdp.heart-institute.nl/dataset/dda57a52-4629-4d5e-b750-e0612420e0fa
type: Dataset
applicable legislation: oj
max typical age: 73
min typical age: 9
number of unique individuals: 550
population coverage: collection type: Cohort,Population-based | data categories: Medical records | materials: Not available | omics: Not available | imaging: N | sex: Female,Male
access rights: RESTRICTED
creator: Dutch Cardiovascular Alliance (DCVA)
description: Rationale: Whilst patients with a tetralogy of Fallot have excellent survival in the present day, adverse events still occur regularly. However,risk stratification in these patients is not sufficient at this moment. Objective: The objective of this study is to report the long-term follow-up after ToF repair in a relatively large cohort and to determine predictors of long-term adverse outcomes. Study design: Retrospective observational study Study population: patients operated for tetralogy of Fallot in in the Netherlands Intervention (if applicable): n/a Main study parameters/endpoints: Cardiac related adverse events during the follow-up of tetralogy of Fallot
issued: 2021-01-01T00:00:00+00:00
language: en
modified: 2026-05-13T11:46:13.740660
provenance: ProvenanceStatement
publisher: Dutch Cardiovascular Alliance (DCVA)
spatial: NLD
temporal: PeriodOfTime
  end date: 2025-12-31T00:00:00+00:00
  start date: 2021-01-01T00:00:00+00:00
title: Outflow tract related aging with congenital heart defects: identifying causes and mechanisms of myocardial and large vessel wall adaptation, predictors for long term outcome and targets for improved treatment. Workpackage retroFallot study
contact point: Kind
  fn: DCVA
  has URL: ']
keyword: Cohort
keyword: Female
keyword: Male
keyword: Medical records
keyword: Not available
keyword: OUTREACH
keyword: Population-based
qualified attribution: Attribution
  agent: Dutch Cardiovascular Alliance (DCVA)
theme: HEAL

Circulating Nanotraces to Identify the Cause of Stroke
type: Dataset
applicable legislation: oj
population coverage: collection type: Disease specific,Sample collection | disease: Subarachnoid haemorrhage,Intracerebral haemorrhage,Cerebral infarction,Stroke, not specified as haemorrhage or infarction,Transient cerebral ischaemic attack, unspecified | data categories: Biological samples,Imaging data,Medical records,Physiological/Biochemical measurements | materials: Plasma | omics: Other | imaging: Y | sex: Female,Male
access rights: RESTRICTED
creator: Dutch Cardiovascular Alliance (DCVA)
description: To develop a liquid biopsy biomarker that can differentiate between the cause of stroke (ischemic and hemorrhagic stroke) in the acute phase, new technology will be developed and nanoparticles (small RNAs and extracellular vesicles) will be measured in plasma samples from patients with a supsicion of stroke.
issued: 2018-11-01T00:00:00+00:00
language: en
modified: 2026-05-13T11:45:48.961020
provenance: ProvenanceStatement
publisher: Dutch Cardiovascular Alliance (DCVA)
spatial: NLD
temporal: PeriodOfTime
  end date: 2022-10-31T00:00:00+00:00
  start date: 2018-11-01T00:00:00+00:00
contact point: Kind
  fn: DCVA
  has URL: ']
keyword: Biological samples
keyword: CINTICS
keyword: Cerebral infarction
keyword: Disease specific
keyword: Female
keyword: Imaging data
keyword: Intracerebral haemorrhage
keyword: Male
keyword: Medical records
keyword: Other
keyword: Physiological Biochemical measurements
keyword: Plasma
keyword: Sample collection
keyword: Stroke
keyword: Subarachnoid haemorrhage
keyword: Transient cerebral ischaemic attack
keyword: not specified as haemorrhage or infarction
keyword: unspecified
qualified attribution: Attribution
  agent: Dutch Cardiovascular Alliance (DCVA)
theme: HEAL

Ablatie registratie
type: Dataset
applicable legislation: oj
health category: Q10379
population coverage: Patiënten (kinderen en volwassenen) die een ablatie hebben ondergaan.
access rights: RESTRICTED
accrual periodicity: ANNUAL
creator: Nederlandse Hart Registratie
description: De Ablatie registratie omvat verschillende typen interventies gericht op het behandelen van verschillende hartritmestoornissen. Dit omvat onder andere His-ablaties, katheterablaties voor aandoeningen zoals atriale flutter, atriumfibrilleren, AV-nodale re-entry tachycardie (AVNRT), atriale tachycardie, ventriculaire extrasystolen (VES), en ventriculaire tachycardieën. Ook ablatie voor accessoire verbindingen en minimaal-invasieve chirurgische ablaties voor atriumfibrilleren, uitgevoerd via een thoracoscopische benadering, worden geregistreerd. Elke ablatie of poging tot ablatie wordt vastgelegd vanaf het moment van de eerste huidincisie. Diagnostische elektrofysiologische onderzoeken zonder geplande ablatie worden niet opgenomen in de registratie. Minimaal-invasieve chirurgische ablaties worden geregistreerd als ze niet gecombineerd worden met andere openhartchirurgie, zoals klep- of bypassoperaties. In het geval van gecombineerde procedures worden deze interventies opgenomen in de cardiochirurgieregistratie en niet in de ablatie-registratie.
issued: 2013-01-01T00:00:00+00:00
language: NLD
modified: 2026-05-13T11:44:23.368375
provenance: ProvenanceStatement
publisher: Nederlandse Hart Registratie
spatial: NLD
temporal: PeriodOfTime
  start date: 2013-01-01T00:00:00+00:00
contact point: Kind
  fn: NHR
  has URL: ']
keyword: Electrophysiology
keyword: ablatie
keyword: ablation
keyword: atrial fibrillation
keyword: heart
keyword: quality registry
qualified attribution: Attribution
  agent: Nederlandse Hart Registratie
theme: HEAL

https://fdp.heart-institute.nl/dataset/e62b5b3e-8003-40eb-a4bc-f5d738a20b35
type: Dataset
applicable legislation: oj
max typical age: 105
min typical age: 18
population coverage: collection type: Cohort,Cross-sectional,Hospital,Longitudinal | disease: Ischaemic heart diseases,Other forms of heart disease,Cerebrovascular diseases | data categories: Medical records | materials: Plasma,Serum,Whole Blood | omics: Not available | imaging: N | sex: Female,Male
access rights: RESTRICTED
creator: Dutch Cardiovascular Alliance (DCVA)
description: Using big data analytics to develop flexible and improved cardiovascular risk prediction algorithms integrated and 'live' in routine clinical practice in order to improve cardiovascular prevention.
issued: 2018-11-15T00:00:00+00:00
language: en
modified: 2026-05-13T11:43:48.903577
provenance: ProvenanceStatement
publisher: Dutch Cardiovascular Alliance (DCVA)
spatial: NLD
temporal: PeriodOfTime
  end date: 2021-11-15T00:00:00+00:00
  start date: 2018-11-15T00:00:00+00:00
title: Improving prevention of cardiovascular disease: from proof of principle to implementation readiness of a live cardiovascular risk management dashboard in electronic health record in routine clinical practice
contact point: Kind
  fn: DCVA
  has URL: ']
keyword: CVRM-IMPROVE
keyword: Cerebrovascular diseases
keyword: Cohort
keyword: Cross-sectional
keyword: Female
keyword: Hospital
keyword: Ischaemic heart diseases
keyword: Longitudinal
keyword: Male
keyword: Medical records
keyword: Not available
keyword: Other forms of heart disease
keyword: Plasma
keyword: Serum
keyword: Whole Blood
qualified attribution: Attribution
  agent: Dutch Cardiovascular Alliance (DCVA)
theme: HEAL

DOMESTICO prospectief
type: Dataset
applicable legislation: oj
number of unique individuals: 1300
population coverage: collection type: Longitudinal | disease: Chronic kidney disease | data categories: Medical records,National registries,Other,Survey data | materials: Not available | omics: Not available | imaging: N | sex: Female,Male
access rights: RESTRICTED
creator: Dutch Cardiovascular Alliance (DCVA)
description: DOMESTICO or the Dutch nOcturnal and hoME dialysis Study To Improve Clinical Outcomes is a nationwide, combined retrospective and prospective, observational cohort study that included adult patients who started with a form of dialysis. The retrospective part of DOMESTICO (2012-2017, n = ± 1300 pts) focuses on clinical outcomes of home dialysis, in particular technique failure and hospitalization, compared to in-center hemodialysis, and on identifying modifiable factors. The prospective part of DOMESTICO (2017-2022, n = ± 2000 pts) focuses on 1. Determining the effects of home dialysis on various aspects of quality of life compared to in-center hemodialysis, measured by patient reported outcome measures (PROMs); and 2. Performing a cost-effectiveness analysis of the various forms of home dialysis compared to in-center hemodialysis, which should contribute to higher value-based health care (i.e. maximum value of patient care at the best costs).
issued: 2017-01-12T00:00:00+00:00
language: en
modified: 2026-05-13T11:46:27.809250
provenance: ProvenanceStatement
publisher: Dutch Cardiovascular Alliance (DCVA)
spatial: NLD
temporal: PeriodOfTime
  end date: 2022-12-31T00:00:00+00:00
  start date: 2017-01-12T00:00:00+00:00
contact point: Kind
  fn: DCVA
  has URL: ']
keyword: Chronic kidney disease
keyword: DOMESTICO
keyword: Female
keyword: Longitudinal
keyword: Male
keyword: Medical records
keyword: National registries
keyword: Not available
keyword: Other
keyword: Survey data
qualified attribution: Attribution
  agent: Dutch Cardiovascular Alliance (DCVA)
theme: HEAL

https://fdp.heart-institute.nl/dataset/f45c1a98-0d47-45d9-9deb-c043c952f133
type: Dataset
applicable legislation: oj
max typical age: 60
min typical age: 18
population coverage: collection type: Cohort,Disease specific,Longitudinal | data categories: Biological samples,Imaging data,Medical records,National registries,Physiological/Biochemical measurements | materials: Plasma | omics: Not available | imaging: Y | sex: Female,Male
access rights: RESTRICTED
creator: Dutch Cardiovascular Alliance (DCVA)
description: Retrospective cohort study in patients with atrial switch operation, longitudinal Follow Up
issued: 2021-01-01T00:00:00+00:00
language: en
modified: 2026-05-13T11:46:16.403900
provenance: ProvenanceStatement
publisher: Dutch Cardiovascular Alliance (DCVA)
spatial: NLD
temporal: PeriodOfTime
  end date: 2025-12-31T00:00:00+00:00
  start date: 2021-01-01T00:00:00+00:00
title: Outflow tract related aging with congenital heart defects: identifying causes and mechanisms of myocardial and large vessel wall adaptation, predictors for long term outcome and targets for improved treatment.
contact point: Kind
  fn: DCVA
  has URL: ']
keyword: Biological samples
keyword: Cohort
keyword: Disease specific
keyword: Female
keyword: Imaging data
keyword: Longitudinal
keyword: Male
keyword: Medical records
keyword: National registries
keyword: Not available
keyword: OUTREACH
keyword: Physiological Biochemical measurements
keyword: Plasma
qualified attribution: Attribution
  agent: Dutch Cardiovascular Alliance (DCVA)
theme: HEAL

Comprehensive, High definition Accelerated Non-invasive Cardiac MRI for Early diagnosis of patients with symptomatic heart disease
type: Dataset
applicable legislation: oj
min typical age: 18
population coverage: collection type: Other | disease: Diastolic (congestive) heart failure | data categories: Imaging data | materials: Not available | omics: Not available | imaging: Y | sex: Female,Male
access rights: RESTRICTED
creator: Dutch Cardiovascular Alliance (DCVA)
description: This project is focused on developing new MRI hardware and software for improved phenotyping of patients with HFpEF
issued: 2016-01-01T00:00:00+00:00
language: en
modified: 2026-05-13T11:47:29.342210
provenance: ProvenanceStatement
publisher: Dutch Cardiovascular Alliance (DCVA)
spatial: NLD
temporal: PeriodOfTime
  end date: 2022-02-01T00:00:00+00:00
  start date: 2016-01-01T00:00:00+00:00
contact point: Kind
  fn: DCVA
  has URL: ']
keyword: CHANCE
keyword: Diastolic congestive heart failure
keyword: Female
keyword: Imaging data
keyword: Male
keyword: Not available
keyword: Other
qualified attribution: Attribution
  agent: Dutch Cardiovascular Alliance (DCVA)
theme: HEAL

Princess Máxima Center
type: Agent

University Medical Center Utrecht
type: Agent

University Medical Center Utrecht
type: Agent

University Medical Center Utrecht
type: Agent

University Medical Center Utrecht
type: Agent

University Medical Center Utrecht
type: Agent

University Medical Center Utrecht
type: Agent

University Medical Center Utrecht
type: Agent

University Medical Center Utrecht
type: Agent

University Medical Center Utrecht
type: Agent

Princess Máxima Center
type: Agent

Amsterdam Dementia Cohort
type: DatasetSeries
description: The Amsterdam Dementia Cohort is an ongoing data collection including all patients who come to the Alzheimer Center Amsterdam for diagnostic work up and who consent to give all data, collected as part of the routine diagnostic work up, for research. The aim is to facilitate research into new and existing biomarkers in the broadest sense, to establish diagnostic, prognostic and theragnostic values and further insight into the pathogenesis of neurodegenerative dementias.
issued: 2026-03-12T08:17:02.525543
modified: 2026-05-13T11:33:27.325353
contact point: Kind
  fn: Amsterdam Dementia Cohort