27 datasets gevonden

Follow up of women (with obesity and unfulfilled wish for a child) and their children who participated in a preconception lifestyle intervention with focus on women's lifestyle,...

The bicuspid aortic valve is generally considered to be a result of a congenital fusion of two out of three leaflets. We found that the non-coronary leaflet develops from the...

multicenter, prospective randomised controlled trial to evaluate the efficacy of a watchful waiting strategy (rate control for symptom relief) compared to routine care...

primary aim: study molecular mechanisms of AF by combining histology, biochemical analysis, and genome-wide RNA expression profiles. Secondary aim: study the incidence of AF...

A campaign to inform the general public and online tools to evaluate indications for cardiogenetic referral will be launched. The yield of novel methods to reach out to family...

Dilated cardiomyopathy is a major cause of heart failure and is the main indication of cardiac transplantation. About 30-50% of the cases can be explained by genetic...

Population-based study investigating the diagnostic yield of stress perfusion MRI for early detection of coronary heart disease in asymptomatic individuals with increased...

Retrospective cohort study in patients with atrial switch operation, longitudinal Follow Up

The RESCUED study investigates the risk of a sudden cardiac arrest in diabetes patients. The aim is to improve recognition of individuals at high risk of sudden cardiac arrest...

this is not one project but a collection of cohort studies, human experimental words and much more

To develop a liquid biopsy biomarker that can differentiate between the cause of stroke (ischemic and hemorrhagic stroke) in the acute phase, new technology will be developed...

Extracellular vesicle proteins in plasma subfractions are investigated to determine their ability for early diagnosis of stable and unstable angina using a blood test

PAH is a deadly disease characterized by abnormal remodelling of pulmonary vessels, leading to a progressive increase in pulmonary artery pressure and right heart failure....

Inherited cardiomyopathies (CM) are clinically heterogeneous: age of onset and disease-severity differ greatly between patients with the exact same gene mutation. The mechanisms...

longitudinal follow-up program for unaffected mutation carriers at risk for developing pulmonary arterial hypertension

CCTA and adenosine CMR imaging of women and men with chest pain symptoms

In this phase 2 trial, we expect to obtain proof of concept for a beneficial effect of GGA on HFpEF. In HFpEF patients we will evaluate effects of GGA on signs and symptoms of...

We have from the atheroexpress biobank (UMCU) cell isolates from atherectomy samples and blood cells

IN-CONTROL II will seek to i. unravel the mechanisms driving 'trained immunity" in patients, taking into account the impact of senescence, age, gender and obesity, ii. elucidate...

see below