22 datasets gevonden

Rationale: Tetralogy of Fallot is the most common type of cyanotic congenital heart disease. The main problems of this patient population are heart failure related to chronic...

The bicuspid aortic valve is generally considered to be a result of a congenital fusion of two out of three leaflets. We found that the non-coronary leaflet develops from the...

primary aim: study molecular mechanisms of AF by combining histology, biochemical analysis, and genome-wide RNA expression profiles. Secondary aim: study the incidence of AF...

A campaign to inform the general public and online tools to evaluate indications for cardiogenetic referral will be launched. The yield of novel methods to reach out to family...

Dilated cardiomyopathy is a major cause of heart failure and is the main indication of cardiac transplantation. About 30-50% of the cases can be explained by genetic...

this is not one project but a collection of cohort studies, human experimental words and much more

PAH is a deadly disease characterized by abnormal remodelling of pulmonary vessels, leading to a progressive increase in pulmonary artery pressure and right heart failure....

Inherited cardiomyopathies (CM) are clinically heterogeneous: age of onset and disease-severity differ greatly between patients with the exact same gene mutation. The mechanisms...

longitudinal follow-up program for unaffected mutation carriers at risk for developing pulmonary arterial hypertension

CCTA and adenosine CMR imaging of women and men with chest pain symptoms

In this phase 2 trial, we expect to obtain proof of concept for a beneficial effect of GGA on HFpEF. In HFpEF patients we will evaluate effects of GGA on signs and symptoms of...

We have from the atheroexpress biobank (UMCU) cell isolates from atherectomy samples and blood cells

We collected cardiac data (history, phusica; examination, Echo, ECG, Blood) from 1550 chidlhood cancer survivors and 250 sibling.

Double blind randomised clinical trial with colchicin/ placebo in patients with chronic coronary disease. 5552 Pts in Netherlands and Australia

A diagnostic cluster randomized trial in patients participating in primary care disease management programs for COPD or type 2 diabetes. An early diagnosis strategy will be...

IN-CONTROL II will seek to i. unravel the mechanisms driving 'trained immunity" in patients, taking into account the impact of senescence, age, gender and obesity, ii. elucidate...

Atrial fibrillation (AF) is the most common age-related cardiac rhythm disorder accounting for about one-third of rhythm abnormalities related hospitalizations with annual costs...

longitudinal follow-up program for early detection of PAH in unaffected carriers. these carriers are compared with Idiopathic PAH patients, heritable PAH patients and healthy...

Using big data analytics to develop flexible and improved cardiovascular risk prediction algorithms integrated and 'live' in routine clinical practice in order to improve...

Investigation whether low-level, aiming for serum concentrations 0.5-0.9ng/mL, digoxin on top of standard treatment (guideline-recommended therapy), is beneficial in HF patients...