Outflow tract related aging with congenital heart disease. Workpackage Tetraogy of fallot High Intensity Interval Training

Rationale: Tetralogy of Fallot is the most common type of cyanotic congenital heart disease. The main problems of this patient population are heart failure related to chronic pulmonary regurgitation, arrhythmias and sudden cardiac death. A major gap in our knowledge is how coupling between the RV and pulmonary artery affects outcomes. It has been shown that aortic pulse wave velocity can be improved by exercise training in Tetralogy of Fallot. Objective: Primary Objective: To examine the effect of an online based exercise training protocol on ventriculo-arterial coupling , as assessed by pulse wave velocity in the aorta and pulmonary artery in patients operated for Tetralogy of Fallot. Study design: cross-over interventional study. All children and young adults will be randomized in 2 groups. One group will start with care/exercise as usual, the other group will start with an online exercise training. After 12 weeks the groups will change from protocol. Before start of measurements, after 12 weeks and group 2 after 24 weeks, all participants will undergo a number of tests, including echocardiogram, cardiopulmonary exercise test, and cardiac magnetic resonance imaging. Study population: 12-30 years of age, after surgical repair of tetralogy of Fallot (TOF), being followed at one of the 2 locations of the Academic Center for Congenital Heart disease (ACAHA). Intervention: 12 weeks of online based interval training 3 times a week. Main study parameters/endpoints: Decrease in pulse wave velocity in the aorta and pulmonary artery measured by MRI.

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Titel	Outflow tract related aging with congenital heart disease. Workpackage Tetraogy of fallot High Intensity Interval Training
Omschrijving	Rationale: Tetralogy of Fallot is the most common type of cyanotic congenital heart disease. The main problems of this patient population are heart failure related to chronic pulmonary regurgitation, arrhythmias and sudden cardiac death. A major gap in our knowledge is how coupling between the RV and pulmonary artery affects outcomes. It has been shown that aortic pulse wave velocity can be improved by exercise training in Tetralogy of Fallot. Objective: Primary Objective: To examine the effect of an online based exercise training protocol on ventriculo-arterial coupling , as assessed by pulse wave velocity in the aorta and pulmonary artery in patients operated for Tetralogy of Fallot. Study design: cross-over interventional study. All children and young adults will be randomized in 2 groups. One group will start with care/exercise as usual, the other group will start with an online exercise training. After 12 weeks the groups will change from protocol. Before start of measurements, after 12 weeks and group 2 after 24 weeks, all participants will undergo a number of tests, including echocardiogram, cardiopulmonary exercise test, and cardiac magnetic resonance imaging. Study population: 12-30 years of age, after surgical repair of tetralogy of Fallot (TOF), being followed at one of the 2 locations of the Academic Center for Congenital Heart disease (ACAHA). Intervention: 12 weeks of online based interval training 3 times a week. Main study parameters/endpoints: Decrease in pulse wave velocity in the aorta and pulmonary artery measured by MRI.
Keywords	Case-Control Disease specific Female Imaging data Longitudinal Male Medical records Not available OUTREACH ToFHIIT study Physiological... Population-based Serum Survey data
Contact points	Contact point 1 URI Naam DCVA Name (translations) Email info@dcvalliance.nl Identifier URL https://www.dcvalliance.nl/
Publisher	Publisher 1 URI Naam Dutch Cardiovascular Alliance (DCVA) Name (translations) Email info@dcvalliance.nl URL https://www.dcvalliance.nl/ Type Publisher note Publisher type Identifier DCVA
Creator	Creator 1 URI Naam Dutch Cardiovascular Alliance (DCVA) Name (translations) Email info@dcvalliance.nl URL https://www.dcvalliance.nl/ Type Publisher note Publisher type Identifier DCVA
Landing page
Release date	2020-01-01T00:00:00+00:00
Modification date
In Series
Versie
Version notes
Identifier	DCVA-063
Frequency
Provenance
Type
Temporal coverage	Temporal coverage 1 Start 2020-01-01T00:00:00+00:00 End 2025-12-31T00:00:00+00:00
Temporal resolution
Spatial coverage	Spatial coverage 1 URI http://publications.europa.eu/resource/authority/country/NLD Label Geometry Bounding Box Centroid
Spatial resolution in meters
Access rights	http://publications.europa.eu/resource/authority/access-right/RESTRICTED
Other identifier
Theme	http://publications.europa.eu/resource/authority/data-theme/HEAL
Taal	http://id.loc.gov/vocabulary/iso639-1/en
Documentation
Conforms to
Is referenced by
Distribution
Sample
Analytics
Applicable legislation	http://data.europa.eu/eli/reg/2025/327/oj
Has version
Code values
Coding system
Purpose
Health category
Health theme
Legal basis
Minimum typical age	12
Maximum typical age	43
Number of records
Number of records for unique individuals.	30
Personal data
Publisher note
Publisher type
Trusted Data Holder
Population coverage	collection type: Case-Control,Disease specific,Longitudinal,Population-based \| data categories: Imaging data,Medical records,Physiological/Biochemical measurements,Survey data \| materials: Serum \| omics: Not available \| imaging: Y \| sex: Female,Male
Retention period
Health data access body
Qualified relation
Provenance activity
Qualified attribution	Attribution 1 Agent Agent 1 URI Naam Dutch Cardiovascular Alliance (DCVA) Name (translations) Email info@dcvalliance.nl URL https://www.dcvalliance.nl/ Homepage Type Identifier DCVA Rol
Quality annotations
URI	https://fdp.heart-institute.nl/dataset/5b7df7f3-2b6d-4b7b-88a9-9246e013701f